Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis

Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease

(2017) Omar A. Mesarwi et al.   PLoS One

Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

(2016) Rebecca L. Kusko et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Drug Treatment of Idiopathic Pulmonary Fibrosis

(2016) William J. Canestaro et al.   CHEST

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

(2016) Hiroaki Semba et al.   Nature Communications

Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients

(2016) Gabriela Jiménez-Valerio et al.   Cell Reports

Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling

(2016) Elizabeth Allen et al.   Cell Reports

Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy

(2016) Laura Pisarsky et al.   Cell Reports

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

(2015) Na Xie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Novel Genomic Signature with Translational Significance for Human Idiopathic Pulmonary Fibrosis

(2015) Yasmina Bauer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Integrative phenotyping framework (iPF): integrative clustering of multiple omics data identifies novel lung disease subphenotypes

(2015) SungHwan Kim et al.   BMC GENOMICS

Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined13C Hyperpolarized Magnetic Resonance and Echocardiography Study

(2015) Lydia M. Le Page et al.   DIABETES

Pharmacological treatment of idiopathic pulmonary fibrosis: an update

(2015) Paolo Spagnolo et al.   DRUG DISCOVERY TODAY

Metabolic Reprogramming Is Required for Myofibroblast Contractility and Differentiation

(2015) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate Dehydrogenase Kinase 1 Participates in Macrophage Polarization via Regulating Glucose Metabolism

(2015) Zheng Tan et al.   JOURNAL OF IMMUNOLOGY

Fibrocyte-like cells mediate acquired resistance to anti-angiogenic therapy with bevacizumab

(2015) Atsushi Mitsuhashi et al.   Nature Communications

Cellular Mechanisms of Tissue Fibrosis. 7. New insights into the cellular mechanisms of pulmonary fibrosis

(2014) Christina E. Barkauskas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Hypoxia-Inducible Factor HIF-1A as Transcriptional Regulator of the A2B Adenosine Receptor during Acute Lung Injury

(2014) T. Eckle et al.   JOURNAL OF IMMUNOLOGY

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury

(2014) Tobias Deuse et al.   NATURE

Lactate, a Novel Trigger of Transforming Growth Factor-β Activation in Idiopathic Pulmonary Fibrosis

(2013) Rubin M. Tuder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

Pathogenesis, current treatments and future directions for idiopathic pulmonary fibrosis

(2013) Hillary Loomis-King et al.   CURRENT OPINION IN PHARMACOLOGY

Long-term safety of dichloroacetate in congenital lactic acidosis

(2013) Monica Abdelmalak et al.   MOLECULAR GENETICS AND METABOLISM

HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1-3 and PKM2

(2013) Alessandro Prigione et al.   STEM CELLS

Hypermethylation-mediated silencing of p14ARF in fibroblasts from idiopathic pulmonary fibrosis

(2012) José Cisneros et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lactic Acid Is Elevated in Idiopathic Pulmonary Fibrosis and Induces Myofibroblast Differentiation via pH-Dependent Activation of Transforming Growth Factor-β

(2012) Robert Matthew Kottmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Altered DNA Methylation Profile in Idiopathic Pulmonary Fibrosis

(2012) Yan Y. Sanders et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Loss of Fibroblast HIF-1  Accelerates Tumorigenesis

(2012) J.-w. Kim et al.   CANCER RESEARCH

Pulmonary fibrosis: patterns and perpetrators

(2012) Paul W. Noble et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype

(2012) Claire M Robinson et al.   RESPIRATORY RESEARCH

Hypoxia-inducible factor-1α mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis

(2011) Manabu Ueno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia-inducible factor signaling in the development of tissue fibrosis

(2011) Debra F. Higgins et al.   CELL CYCLE

Myofibroblast differentiation and survival in fibrotic disease

(2011) Kornelia Kis et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

(2010) C. H. Osterreicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Hypoxia-Inducible Factor 1  Induces Fibrosis and Insulin Resistance in White Adipose Tissue

(2009) N. Halberg et al.   MOLECULAR AND CELLULAR BIOLOGY

Pulmonary fibrosis: pathogenesis, etiology and regulation

(2009) M S Wilson et al.   Mucosal Immunology

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

Role of dichloroacetate in the treatment of genetic mitochondrial diseases☆

(2008) Peter W. Stacpoole et al.   ADVANCED DRUG DELIVERY REVIEWS

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

(2008) A. J. Trimboli et al.   CANCER RESEARCH

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Mitochondria as targets for cancer chemotherapy

(2008) Vladimir Gogvadze et al.   SEMINARS IN CANCER BIOLOGY