Recent development and optimization of pseudomonas aeruginosa exotoxin immunotoxins in cancer therapeutic applications
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Recent development and optimization of pseudomonas aeruginosa exotoxin immunotoxins in cancer therapeutic applications
Authors
Keywords
PE recombinant immunotoxins, Immunogenicity, Non-specific cytotoxicity
Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 96, Issue -, Pages 107759
Publisher
Elsevier BV
Online
2021-05-24
DOI
10.1016/j.intimp.2021.107759
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Breast cancer targeted/ therapeutic with double and triple fusion Immunotoxins
- (2020) Zoleikha Goleij et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation
- (2020) Ronit Mazor et al. Frontiers in Immunology
- Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy
- (2020) Michael Dieffenbach et al. Biomolecules
- Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts
- (2020) Vedud Purde et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pseudomonas Exotoxin A Based Toxins Targeting Epidermal Growth Factor Receptor for the Treatment of Prostate Cancer
- (2020) Alexandra Fischer et al. Toxins
- Pseudomonas Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient’s Bedside to Evaluation in Preclinical Models
- (2019) Yasmin Leshem et al. Toxins
- Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models
- (2019) Zoë Shancer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deimmunizing substitutions in Pseudomonas exotoxin domain III perturb antigen processing without eliminating T-cell epitopes
- (2019) Daniel L. Moss et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Depletion of PD-1-positive cells ameliorates autoimmune disease
- (2019) Peng Zhao et al. Nature Biomedical Engineering
- Oncolytic Viruses: Priming Time for Cancer Immunotherapy
- (2019) Luke Russell et al. BIODRUGS
- New treatment options in hairy cell leukemia with focus on BRAF inhibitors
- (2019) Brunangelo Falini et al. HEMATOLOGICAL ONCOLOGY
- Ricin: An Ancient Story for a Timeless Plant Toxin
- (2019) Letizia Polito et al. Toxins
- Construction of an immunotoxin via site-specific conjugation of anti-Her2 IgG and engineered Pseudomonas exotoxin A
- (2019) Byeong Sung Lee et al. Journal of Biological Engineering
- The engineered anti‐GPC3 immunotoxin, HN3‐ABD‐T20, produces regression in mouse liver cancer xenografts via prolonged serum retention
- (2019) Bryan D. Fleming et al. HEPATOLOGY
- Tagraxofusp, the first CD123-targeted therapy and first targeted treatment for blastic plasmacytoid dendritic cell neoplasm
- (2019) Minas P. Economides et al. Expert Review of Clinical Pharmacology
- A novel approach to assess domain specificity of anti-drug antibodies to moxetumomab pasudotox, an immunotoxin with two functional domains
- (2019) Inna Vainshtein et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Critical Issues in the Development of Immunotoxins for Anticancer Therapy
- (2019) Ji-Sun Kim et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Antibody-Drug Conjugates: A Comprehensive Review
- (2019) Puregmaa Khongorzul et al. MOLECULAR CANCER RESEARCH
- HER2-specific immunotoxins constructed based on single-domain antibodies and the improved toxin PE24X7
- (2019) Li Cao et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Site-Specific PEGylation of Anti-Mesothelin Recombinant Immunotoxins Increases Half-life and Antitumor Activity
- (2019) Zeliang Zheng et al. MOLECULAR CANCER THERAPEUTICS
- Generation of Potent Anti-HER1/2 Immunotoxins by Protein Ligation Using Split Inteins
- (2018) Thomas Pirzer et al. ACS Chemical Biology
- Tumor-Shed Antigen Affects Antibody Tumor Targeting: Comparison of Two 89Zr-Labeled Antibodies Directed against Shed or Nonshed Antigens
- (2018) Jae-Ho Lee et al. Contrast Media & Molecular Imaging
- The algal chloroplast as a synthetic biology platform for production of therapeutic proteins
- (2018) Yuliya M. Dyo et al. MICROBIOLOGY-SGM
- Improving theIn VivoEfficacy of an Anti-Tac (CD25) Immunotoxin byPseudomonasExotoxin A Domain II Engineering
- (2018) Gilad Kaplan et al. MOLECULAR CANCER THERAPEUTICS
- Expression of VGRNb-PE immunotoxin in transplastomic lettuce (Lactuca sativa L.)
- (2018) Malihe Mirzaee et al. PLANT MOLECULAR BIOLOGY
- Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors
- (2018) Pedro Miguel Lacal et al. PHARMACOLOGICAL RESEARCH
- Reduction of non-specific toxicity of immunotoxin by intein mediated reconstitution on target cells
- (2018) Jing Wang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Immune checkpoint blockade opens a new way to cancer immunotherapy
- (2018) Sanam Sadreddini et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Protein Synthesis Inhibition Activity of Mesothelin Targeting Immunotoxin LMB-100 Decreases Concentrations of Oncogenic Signaling Molecules and Secreted Growth Factors
- (2018) Salma El-Behaedi et al. Toxins
- Humanized CD7 nanobody-based immunotoxins exhibit promising anti-T-cell acute lymphoblastic leukemia potential
- (2017) Yuan Yu et al. International Journal of Nanomedicine
- Immunotoxins in cancer therapy: Review and update
- (2017) Bahman Akbari et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Novel PSCA targeting scFv-fusion proteins for diagnosis and immunotherapy of prostate cancer
- (2017) Claudia Kessler et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Recombinant immunotoxins targeting B-cell maturation antigen are cytotoxic to myeloma cell lines and myeloma cells from patients
- (2017) T K Bera et al. LEUKEMIA
- Immunotoxin: A new tool for cancer therapy
- (2017) Hossein Allahyari et al. TUMOR BIOLOGY
- Anti-tumor activity of an immunotoxin (TGFα-PE38) delivered by attenuated Salmonella typhimurium
- (2017) Daejin Lim et al. Oncotarget
- Engineered Ssp DnaX inteins for protein splicing with flanking proline residues
- (2017) Xiao Zhang et al. SAUDI JOURNAL OF BIOLOGICAL SCIENCES
- Efficient generation of bispecific IgG antibodies by split intein mediated protein trans-splicing system
- (2017) Lei Han et al. Scientific Reports
- Immunotoxin Against a Donor MHC Class II Molecule Induces Indefinite Survival of Murine Kidney Allografts
- (2016) K. Brown et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a phase I/II clinical trial
- (2016) Vidyalakshmi Chandramohan et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- HER2-targeted immunotoxins with low nonspecific toxicity and immunogenicity
- (2016) Rui Guo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- High-level extracellular secretion of organophosphorous hydrolase ofFlavobacteriumsp. inEscherichia coliBL21(DE3)pLysS
- (2016) Soudeh Khanamani Falahati-Pour et al. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
- The future of antiviral immunotoxins
- (2016) Katja Spiess et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin-Targeting Recombinant Immunotoxins
- (2016) Prince Awuah et al. MOLECULAR CANCER THERAPEUTICS
- Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity
- (2016) Ronit Mazor et al. Oncotarget
- Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A
- (2016) Gilad Kaplan et al. Toxins
- Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
- (2015) Padmanee Sharma et al. CELL
- Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo
- (2015) Ronit Mazor et al. Cellular & Molecular Immunology
- New Life for Immunotoxin Cancer Therapy
- (2015) R. Hassan et al. CLINICAL CANCER RESEARCH
- Plants as Factories for Human Pharmaceuticals: Applications and Challenges
- (2015) Jian Yao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Advances in Anticancer Immunotoxin Therapy
- (2015) C. Alewine et al. ONCOLOGIST
- Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results
- (2015) Emily Mason-Osann et al. Scientific Reports
- Enhancement in production of recombinant two-chain Insulin Glargine by over-expression of Kex2 protease in Pichia pastoris
- (2014) Suma Sreenivas et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Protein expression in Pichia pastoris: recent achievements and perspectives for heterologous protein production
- (2014) Mudassar Ahmad et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Potent Control of Acute Graft-Versus-Host Disease Lethality After Immunization With a Novel DNA Vaccine Targeted to B7-1/CD28 Costimulatory Signaling Pathway
- (2013) Yuan Luo et al. JOURNAL OF IMMUNOTHERAPY
- Enhanced De Novo Alloantibody and Antibody-Mediated Injury in Rhesus Macaques
- (2012) E. K. Page et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Purification of clinical-grade disulfide stabilized antibody fragment variable—Pseudomonas exotoxin conjugate (dsFv-PE38) expressed in Escherichia coli
- (2012) Hua Jiang et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Antigen Shedding May Improve Efficiencies for Delivery of Antibody-Based Anticancer Agents in Solid Tumors
- (2012) Y. Pak et al. CANCER RESEARCH
- Phase I Trial of Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox (CAT-8015 or HA22) in Patients With Hairy Cell Leukemia
- (2012) Robert J. Kreitman et al. JOURNAL OF CLINICAL ONCOLOGY
- Development of VEGFR2-specific Nanobody Pseudomonas exotoxin A conjugated to provide efficient inhibition of tumor cell growth
- (2012) Mahdi Behdani et al. New Biotechnology
- Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts
- (2011) M. E. Mossoba et al. CLINICAL CANCER RESEARCH
- A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer
- (2011) John E. Weldon et al. FEBS Journal
- Denileukin diftitox in combination with rituximab for previously untreated follicular B-cell non-Hodgkin's lymphoma
- (2011) S M Ansell et al. LEUKEMIA
- HER2-targeting recombinant protein with truncated Pseudomonas Exotoxin: A translocation domain efficiently kills breast cancer cells
- (2010) Li Zhang et al. CANCER BIOLOGY & THERAPY
- A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity
- (2008) J. E. Weldon et al. BLOOD
- Sec61p Is Required for ERAD-L
- (2008) Martin Willer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now