New treatment options in hairy cell leukemia with focus on BRAF inhibitors

Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia

(2018) Robert J. Kreitman et al.   LEUKEMIA

Genomics of Hairy Cell Leukemia

(2017) Enrico Tiacci et al.   JOURNAL OF CLINICAL ONCOLOGY

BRAFV600E mutation in hairy cell leukemia: from bench to bedside

(2016) Brunangelo Falini et al.   BLOOD

BRAF inhibition in hairy cell leukemia with low-dose vemurafenib

(2016) S. Dietrich et al.   BLOOD

Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia

(2016) Michael R. Grever et al.   BLOOD

Evaluation of Allele-Specific PCR and Immunohistochemistry for the Detection of BRAF V600E Mutations in Hairy Cell Leukemia

(2015) Noah A. Brown et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

The Utility of BRAF V600E Mutation-Specific Antibody VE1 for the Diagnosis of Hairy Cell Leukemia

(2015) Guldeep Uppal et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Chemoimmunotherapy for hairy cell leukemia

(2015) Farhad Ravandi   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Long-term follow-up after purine analogue therapy in hairy cell leukaemia

(2015) Monica Else et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Bone marrow and splenic histology in hairy cell leukaemia

(2015) Andrew Wotherspoon et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Cotreatment of Hairy Cell Leukemia and Melanoma With theBRAFInhibitor Dabrafenib

(2015) James S. Blachly et al.   Journal of the National Comprehensive Cancer Network

Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia

(2015) Enrico Tiacci et al.   NEW ENGLAND JOURNAL OF MEDICINE

BRAF mutation detection in hairy cell leukaemia from archival haematolymphoid specimens

(2015) Carla Thomas et al.   PATHOLOGY

Combination therapy with BRAF and MEK inhibitors for melanoma: latest evidence and place in therapy

(2015) Zeynep Eroglu et al.   Therapeutic Advances in Medical Oncology

Rapid and complete hematological response of refractory hairy cell leukemia to the BRAF inhibitor dabrafenib

(2014) V. Vergote et al.   ANNALS OF HEMATOLOGY

BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity

(2014) V. Pettirossi et al.   BLOOD

BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact

(2014) H. Rizos et al.   CLINICAL CANCER RESEARCH

Efficacy of Vemurafenib in Hairy-Cell Leukemia

(2014) Jesvin Samuel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Comprehensive Immunophenotypic Marker Analysis of Hairy Cell Leukemia in Paraffin-Embedded Bone Marrow Trephine Biopsies–A Tissue Microarray Study

(2014) Judit Tóth-Lipták et al.   PATHOLOGY & ONCOLOGY RESEARCH

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors

(2014) Anna A. Marusiak et al.   Nature Communications

Immunohistochemical Detection of Hairy Cell Leukemia in Paraffin Sections Using a Highly Effective CD103 Rabbit Monoclonal Antibody

(2013) Elizabeth A. Morgan et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Successful vemurafenib salvage treatment in a patient with primary refractory hairy cell leukemia and pulmonary aspergillosis

(2013) Helga Maurer et al.   ANNALS OF HEMATOLOGY

Clinical characteristics and long-term outcome of young hairy cell leukemia patients treated with cladribine: a single-institution series

(2013) J. D. Rosenberg et al.   BLOOD

Bendamustine and Rituximab in Relapsed and Refractory Hairy Cell Leukemia

(2013) M. Burotto et al.   CLINICAL CANCER RESEARCH

Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia

(2013) E. Tiacci et al.   HAEMATOLOGICA

Low-dose vemurafenib induces complete remission in a case of hairy-cell leukemia with a V600E mutation

(2013) F. Peyrade et al.   HAEMATOLOGICA

Rapid Response to Vemurafenib in a Heavily Pretreated Patient With Hairy Cell Leukemia and a BRAF Mutation

(2013) Javier Munoz et al.   JOURNAL OF CLINICAL ONCOLOGY

Pharmacodynamic Effects and Mechanisms of Resistance to Vemurafenib in Patients With Metastatic Melanoma

(2013) Kerstin Trunzer et al.   JOURNAL OF CLINICAL ONCOLOGY

High prevalence of MAP2K1 mutations in variant and IGHV4-34–expressing hairy-cell leukemias

(2013) Joshua J Waterfall et al.   NATURE GENETICS

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

(2013) H. Shi et al.   Cancer Discovery

Application of a BRAF V600E Mutation-specific Antibody for the Diagnosis of Hairy Cell Leukemia

(2012) Mindaugas Andrulis et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M, and HC-1 questions their origin from hairy cell leukemia

(2012) E. Tiacci et al.   BLOOD

Development and validation of a real-time quantification assay to detect and monitor BRAFV600E mutations in hairy cell leukemia

(2012) S. Schnittger et al.   BLOOD

Fludarabine and rituximab for relapsed or refractory hairy cell leukemia

(2012) A. S. Gerrie et al.   BLOOD

Rapid response of biallelicBRAFV600E mutated hairy cell leukaemia to low dose vemurafenib

(2012) George A. Follows et al.   BRITISH JOURNAL OF HAEMATOLOGY

The coding genome of splenic marginal zone lymphoma: activation ofNOTCH2and other pathways regulating marginal zone development

(2012) Davide Rossi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-genome sequencing identifies recurrent somaticNOTCH2mutations in splenic marginal zone lymphoma

(2012) Mark J. Kiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A microRNA signature specific for hairy cell leukemia and associated with modulation of the MAPK–JNK pathways

(2012) Y Kitagawa et al.   LEUKEMIA

Hairy cell leukemia cell lines expressing annexin A1 and displaying B-cell receptor signals characteristic of primary tumor cells lack the signature BRAF mutation to reveal unrepresentative origins

(2012) N J Weston-Bell et al.   LEUKEMIA

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

BRAF Inhibition in Refractory Hairy-Cell Leukemia

(2012) Sascha Dietrich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib

(2012) Jeffrey A. Sosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

RASMutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors

(2012) Fei Su et al.   NEW ENGLAND JOURNAL OF MEDICINE

Melanoma whole-exome sequencing identifies V600E B-RAF amplification-mediated acquired B-RAF inhibitor resistance

(2012) Hubing Shi et al.   Nature Communications

The BRAF V600E mutation in hairy cell leukemia and other mature B-cell neoplasms

(2011) L. Arcaini et al.   BLOOD

Phase 2 study of cladribine followed by rituximab in patients with hairy cell leukemia

(2011) F. Ravandi et al.   BLOOD

Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation

(2011) E. Tiacci et al.   BLOOD

High resolution melting analysis for detection of BRAF exon 15 mutations in hairy cell leukaemia and other lymphoid malignancies

(2011) Elaine M. Boyd et al.   BRITISH JOURNAL OF HAEMATOLOGY

Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling

(2011) Nikhil Wagle et al.   JOURNAL OF CLINICAL ONCOLOGY

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

(2011) Poulikos I. Poulikakos et al.   NATURE

BRAFMutations in Hairy-Cell Leukemia

(2011) Enrico Tiacci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low expression of p27 and low proliferation index do not correlate in hairy cell leukaemia

(2010) Marco Chilosi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hairy cell leukaemia, negative for conventional cell markers, diagnosed using antibodies to Annexin A1 and T-bet

(2010) Walid Sadik et al.   BRITISH JOURNAL OF HAEMATOLOGY

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

How I treat hairy cell leukemia

(2009) M. R. Grever   BLOOD

Long-term follow-up of 233 patients with hairy cell leukaemia, treated initially with pentostatin or cladribine, at a median of 16 years from diagnosis

(2009) Monica Else et al.   BRITISH JOURNAL OF HAEMATOLOGY

High density genome-wide DNA profiling reveals a remarkably stable profile in hairy cell leukaemia

(2008) Francesco Forconi et al.   BRITISH JOURNAL OF HAEMATOLOGY