Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-06-27
DOI
10.3389/fimmu.2020.01261
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Moxetumomab pasudotox: A first-in-class treatment for hairy cell leukemia
- (2019) Karen M Fancher et al. JOURNAL OF ONCOLOGY PHARMACY PRACTICE
- Deimmunizing substitutions in Pseudomonas exotoxin domain III perturb antigen processing without eliminating T-cell epitopes
- (2019) Daniel L. Moss et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Depletion of PD-1-positive cells ameliorates autoimmune disease
- (2019) Peng Zhao et al. Nature Biomedical Engineering
- The engineered anti‐GPC3 immunotoxin, HN3‐ABD‐T20, produces regression in mouse liver cancer xenografts via prolonged serum retention
- (2019) Bryan D. Fleming et al. HEPATOLOGY
- A novel approach to assess domain specificity of anti-drug antibodies to moxetumomab pasudotox, an immunotoxin with two functional domains
- (2019) Inna Vainshtein et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Contextualizing the Use of Moxetumomab Pasudotox in the Treatment of Relapsed or Refractory Hairy Cell Leukemia
- (2019) Robert J. Kreitman et al. ONCOLOGIST
- Targeted Diphtheria Toxin-Based Therapy: A Review Article
- (2019) Fatemeh Shafiee et al. Frontiers in Microbiology
- Strategies to Reduce the Immunogenicity of Recombinant Immunotoxins
- (2018) Ronit Mazor et al. AMERICAN JOURNAL OF PATHOLOGY
- Low-Dose Methotrexate Prevents Primary and Secondary Humoral Immune Responses and Induces Immune Tolerance to a Recombinant Immunotoxin
- (2018) Emily M. King et al. JOURNAL OF IMMUNOLOGY
- Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia
- (2018) Robert J. Kreitman et al. LEUKEMIA
- Improving theIn VivoEfficacy of an Anti-Tac (CD25) Immunotoxin byPseudomonasExotoxin A Domain II Engineering
- (2018) Gilad Kaplan et al. MOLECULAR CANCER THERAPEUTICS
- Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity
- (2018) Ronit Mazor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phase I/II Trial of a Combination of Anti-CD3/CD7 Immunotoxins for Steroid-Refractory Acute Graft-versus-Host Disease
- (2018) Christoph Groth et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Moxetumomab Pasudotox: First Global Approval
- (2018) Sohita Dhillon DRUGS
- Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein
- (2017) B. A. Krishna et al. Nature Communications
- Role of HLA-DP in the Presentation of Epitopes from the Truncated Bacterial PE38 Immunotoxin
- (2016) Ronit Mazor et al. AAPS Journal
- Hypersensitivity and immunologic reactions to biologics: opportunities for the allergist
- (2016) David A. Khan ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
- Immunogenicity of therapeutic recombinant immunotoxins
- (2016) Ronit Mazor et al. IMMUNOLOGICAL REVIEWS
- Mesothelin Immunotherapy for Cancer: Ready for Prime Time?
- (2016) Raffit Hassan et al. JOURNAL OF CLINICAL ONCOLOGY
- An immunoinhibition approach to overcome the impact of pre-existing antibodies on cut point establishment for immunogenicity assessment of moxetumomab pasudotox
- (2016) Amy K. Schneider et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy
- (2016) Frieder Bauss et al. Molecular Oncology
- Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity
- (2016) Ronit Mazor et al. Oncotarget
- Phase I trial of EpCAM-targeting immunotoxin MOC31PE, alone and in combination with cyclosporin
- (2015) Y Andersson et al. BRITISH JOURNAL OF CANCER
- Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo
- (2015) Ronit Mazor et al. Cellular & Molecular Immunology
- Complete Remissions of Adult T-cell Leukemia with Anti-CD25 Recombinant Immunotoxin LMB-2 and Chemotherapy to Block Immunogenicity
- (2015) R. J. Kreitman et al. CLINICAL CANCER RESEARCH
- Enzyme Replacement Therapies and Immunogenicity in Lysosomal Storage Diseases: Is There a Pattern?
- (2015) Paul Harmatz CLINICAL THERAPEUTICS
- Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A
- (2015) Ronit Mazor et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Bortezomib Reduces Pre-Existing Antibodies to Recombinant Immunotoxins in Mice
- (2015) Michael L. Manning et al. JOURNAL OF IMMUNOLOGY
- Recombinant Immunotoxin with T-cell Epitope Mutations That Greatly Reduce Immunogenicity for Treatment of Mesothelin-Expressing Tumors
- (2015) R. Mazor et al. MOLECULAR CANCER THERAPEUTICS
- Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development
- (2015) Joerg U. Schmohl et al. Toxins
- Pseudomonas Exotoxin A: optimized by evolution for effective killing
- (2015) Marta Michalska et al. Frontiers in Microbiology
- Identification of Immunodominant CD4-Restricted Epitopes Co-Located with Antibody Binding Sites in Individuals Vaccinated with ALVAC-HIV and AIDSVAX B/E
- (2015) Silvia Ratto-Kim et al. PLoS One
- Immunotoxins for leukemia
- (2014) A. S. Wayne et al. BLOOD
- Tofacitinib Suppresses Antibody Responses to Protein Therapeutics in Murine Hosts
- (2014) M. Onda et al. JOURNAL OF IMMUNOLOGY
- In Vitro and In Vivo Activity of the Low-Immunogenic Antimesothelin Immunotoxin RG7787 in Pancreatic Cancer
- (2014) K. Hollevoet et al. MOLECULAR CANCER THERAPEUTICS
- Efficacy of RG7787, a Next-Generation Mesothelin-Targeted Immunotoxin, against Triple-Negative Breast and Gastric Cancers
- (2014) C. Alewine et al. MOLECULAR CANCER THERAPEUTICS
- Removing T-cell epitopes with computational protein design
- (2014) C. King et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes
- (2014) R. Mazor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Role of Mesothelin in Tumor Progression and Targeted Therapy
- (2013) Zhewei Tang et al. Anti-Cancer Agents in Medicinal Chemistry
- Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy
- (2013) V. Chandramohan et al. CLINICAL CANCER RESEARCH
- Shaping T Cell – B Cell Collaboration in the Response to Human Immunodeficiency Virus Type 1 Envelope Glycoprotein gp120 by Peptide Priming
- (2013) N. Kalaya Steede et al. PLoS One
- The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases
- (2013) M. Jani et al. RHEUMATOLOGY
- Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression
- (2013) R. Hassan et al. Science Translational Medicine
- Immunotoxins: The Role of the Toxin
- (2013) Antonella Antignani et al. Toxins
- T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans
- (2013) M. V. Maus et al. Cancer Immunology Research
- Successful immune tolerance induction to enzyme replacement therapy in CRIM-negative infantile Pompe disease
- (2012) Yoav H. Messinger et al. GENETICS IN MEDICINE
- Phase I Trial of Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox (CAT-8015 or HA22) in Patients With Hairy Cell Leukemia
- (2012) Robert J. Kreitman et al. JOURNAL OF CLINICAL ONCOLOGY
- Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A
- (2012) R. Mazor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes
- (2012) W. Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer
- (2011) John E. Weldon et al. FEBS Journal
- Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes
- (2011) M. Onda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Peptide binding predictions for HLA DR, DP and DQ molecules
- (2010) Peng Wang et al. BMC BIOINFORMATICS
- Molecular Determinants of T Cell Epitope Recognition to the Common Timothy Grass Allergen
- (2010) C. Oseroff et al. JOURNAL OF IMMUNOLOGY
- A Recombinant Immunotoxin Targeting CD22 With Low Immunogenicity, Low Nonspecific Toxicity, and High Antitumor Activity in Mice
- (2010) Johanna K. Hansen et al. JOURNAL OF IMMUNOTHERAPY
- The immunogenicity of humanized and fully human antibodies
- (2010) Fiona A. Harding et al. mAbs
- Immunotoxin Complementation of HAART to Deplete Persisting HIV-Infected Cell Reservoirs
- (2010) Edward A. Berger et al. PLoS Pathogens
- Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics☆
- (2009) Satoshi Nagata et al. ADVANCED DRUG DELIVERY REVIEWS
- Phase I Trial of Continuous Infusion Anti-Mesothelin Recombinant Immunotoxin SS1P
- (2009) R. J. Kreitman et al. CLINICAL CANCER RESEARCH
- A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity
- (2008) J. E. Weldon et al. BLOOD
- Pseudomonas exotoxin A: From virulence factor to anti-cancer agent
- (2008) Philipp Wolf et al. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
- Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose
- (2008) Christine H. Chung et al. NEW ENGLAND JOURNAL OF MEDICINE
- An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes
- (2008) M. Onda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started