A guide to taming a toxin - recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer

Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes

(2011) M. Onda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PEGylation of therapeutic proteins

(2010) Simona Jevševar et al.   Biotechnology Journal

Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia

(2010) Francis Mussai et al.   BRITISH JOURNAL OF HAEMATOLOGY

A Flow Cytometry Method to Quantitate Internalized Immunotoxins Shows that Taxol Synergistically Increases Cellular Immunotoxins Uptake

(2010) Y. Zhang et al.   CANCER RESEARCH

Anti-CD22 Immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-Positive Hematologic Malignancies of Childhood: Preclinical Studies and Phase I Clinical Trial

(2010) A. S. Wayne et al.   CLINICAL CANCER RESEARCH

Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas

(2010) Chien-Tsun Kuan et al.   INTERNATIONAL JOURNAL OF CANCER

A Recombinant Immunotoxin Targeting CD22 With Low Immunogenicity, Low Nonspecific Toxicity, and High Antitumor Activity in Mice

(2010) Johanna K. Hansen et al.   JOURNAL OF IMMUNOTHERAPY

Endogenous ADP-ribosylation of elongation factor-2 by interleukin-1β

(2010) Doris Jäger et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Pseudomonas Exotoxin A-Mediated Apoptosis Is Bak Dependent and Preceded by the Degradation of Mcl-1

(2010) X. Du et al.   MOLECULAR AND CELLULAR BIOLOGY

The Ero1α-PDI Redox Cycle Regulates Retro-Translocation of Cholera Toxin

(2010) Paul Moore et al.   MOLECULAR BIOLOGY OF THE CELL

ABT-737 Overcomes Resistance to Immunotoxin-Mediated Apoptosis and Enhances the Delivery of Pseudomonas Exotoxin-Based Proteins to the Cell Cytosol

(2010) R. Traini et al.   MOLECULAR CANCER THERAPEUTICS

Denileukin diftitox—a step towards a 'magic bullet' for CTCL

(2010) Marshall E. Kadin et al.   Nature Reviews Clinical Oncology

A Dominant-Negative Approach That Prevents Diphthamide Formation Confers Resistance to Pseudomonas Exotoxin A and Diphtheria Toxin

(2010) Vincent Roy et al.   PLoS One

Pseudomonas exotoxin kills Drosophila S2 cells via apoptosis

(2010) Ashima K. Sharma et al.   TOXICON

Immunotoxin Complementation of HAART to Deplete Persisting HIV-Infected Cell Reservoirs

(2010) Edward A. Berger et al.   PLoS Pathogens

Toxin-Based Therapeutic Approaches

(2010) Assaf Shapira et al.   Toxins

Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics☆

(2009) Satoshi Nagata et al.   ADVANCED DRUG DELIVERY REVIEWS

Extracellular/Microenvironmental Redox State

(2009) Luksana Chaiswing et al.   ANTIOXIDANTS & REDOX SIGNALING

A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions

(2009) Mario A. Izidoro et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression

(2009) Christian Bogner et al.   BRITISH JOURNAL OF HAEMATOLOGY

Initial characterization of an immunotoxin constructed from domains II and III of cholera exotoxin

(2009) Robert Sarnovsky et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Humanized immunotoxins: A new generation of immunotoxins for targeted cancer therapy

(2009) Mrudula Mathew et al.   CANCER SCIENCE

Phase I Trial of Continuous Infusion Anti-Mesothelin Recombinant Immunotoxin SS1P

(2009) R. J. Kreitman et al.   CLINICAL CANCER RESEARCH

CAT-8015: A Second-Generation Pseudomonas Exotoxin A-Based Immunotherapy Targeting CD22-Expressing Hematologic Malignancies

(2009) R. F. Alderson et al.   CLINICAL CANCER RESEARCH

Reducing the Immunogenicity of Protein Therapeutics

(2009) Masanori Onda   CURRENT DRUG TARGETS

Recombinant Immunotoxins for the Treatment of Chemoresistant Hematologic Malignancies

(2009) Robert Kreitman   CURRENT PHARMACEUTICAL DESIGN

Denileukin diftitox: a novel immunotoxin

(2009) George Manoukian et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The KDEL receptor: New functions for an old protein

(2009) Mirco Capitani et al.   FEBS LETTERS

Phase II Trial of Recombinant Immunotoxin RFB4(dsFv)-PE38 (BL22) in Patients With Hairy Cell Leukemia

(2009) Robert J. Kreitman et al.   JOURNAL OF CLINICAL ONCOLOGY

A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity

(2008) J. E. Weldon et al.   BLOOD

Differential Cellular Internalization of Anti-CD19 and -CD22 Immunotoxins Results in Different Cytotoxic Activity

(2008) X. Du et al.   CANCER RESEARCH

The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin

(2008) Pradeep K. Gupta et al.   CELLULAR MICROBIOLOGY

High Shed Antigen Levels within Tumors: An Additional Barrier to Immunoconjugate Therapy

(2008) Y. Zhang et al.   CLINICAL CANCER RESEARCH

The nature and character of the transition state for the ADP-ribosyltransferase reaction

(2008) René Jørgensen et al.   EMBO REPORTS

Pseudomonas exotoxin A: From virulence factor to anti-cancer agent

(2008) Philipp Wolf et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Evidence for Mitochondrial Localization of P5, a Member of the Protein Disulphide Isomerase Family

(2008) T. Kimura et al.   JOURNAL OF BIOCHEMISTRY

Cholix Toxin, a Novel ADP-ribosylating Factor fromVibrio cholerae

(2008) René Jørgensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sec61p Is Required for ERAD-L

(2008) Martin Willer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development

(2008) T. R. Webb et al.   JOURNAL OF CELL SCIENCE

An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

(2008) M. Onda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human PDI family: Versatility packed into a single fold

(2007) Christian Appenzeller-Herzog et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH