Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Intein-mediated cytoplasmic reconstitution of a split toxin enables selective cell ablation in mixed populations and tumor xenografts
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 36, Pages 22090-22100
Publisher
Proceedings of the National Academy of Sciences
Online
2020-08-25
DOI
10.1073/pnas.2006603117
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Biotechnological Applications of Protein Splicing
- (2019) Corina Sarmiento et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in vivo
- (2019) Isabelle Salwig et al. EMBO JOURNAL
- Engineered toxin–intein antimicrobials can selectively target and kill antibiotic-resistant bacteria in mixed populations
- (2019) Rocío López-Igual et al. NATURE BIOTECHNOLOGY
- Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina
- (2019) Patrizia Tornabene et al. Science Translational Medicine
- Ricin: An Ancient Story for a Timeless Plant Toxin
- (2019) Letizia Polito et al. Toxins
- Proximity Induced Splicing Utilizing Caged Split Inteins
- (2019) Josef A. Gramespacher et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Critical Issues in the Development of Immunotoxins for Anticancer Therapy
- (2019) Ji-Sun Kim et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- A mesophilic cysteine-less split intein for protein trans-splicing applications under oxidizing conditions
- (2019) Maniraj Bhagawati et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins
- (2018) Elena Kudryashova et al. CURRENT BIOLOGY
- Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins
- (2018) Francesco Giansanti et al. Toxins
- Switchable inteins for conditional protein splicing
- (2018) Barbara Di Ventura et al. BIOLOGICAL CHEMISTRY
- Efficient and wash-free labeling of membrane proteins using engineered Npu DnaE split-inteins
- (2018) Euiyeon Lee et al. PROTEIN SCIENCE
- Reduction of non-specific toxicity of immunotoxin by intein mediated reconstitution on target cells
- (2018) Jing Wang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Immunotoxins in cancer therapy: Review and update
- (2017) Bahman Akbari et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Secondary Structure Preferences of the Anthrax Toxin Protective Antigen Translocase
- (2017) Debasis Das et al. JOURNAL OF MOLECULAR BIOLOGY
- Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis
- (2017) Josef A. Gramespacher et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A molecular engineering toolbox for the structural biologist
- (2017) Galia T. Debelouchina et al. QUARTERLY REVIEWS OF BIOPHYSICS
- Immunogenicity of therapeutic recombinant immunotoxins
- (2016) Ronit Mazor et al. IMMUNOLOGICAL REVIEWS
- Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting
- (2016) Kuang-Hua Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Peptide- and proton-driven allosteric clamps catalyze anthrax toxin translocation across membranes
- (2016) Debasis Das et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Thioredoxin reductase inhibitor auranofin prevents membrane transport of diphtheria toxin into the cytosol and protects human cells from intoxication
- (2016) Leonie Schnell et al. TOXICON
- Tumor Targeting and Drug Delivery by Anthrax Toxin
- (2016) Christopher Bachran et al. Toxins
- Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins
- (2015) Yael David et al. Nature Chemistry
- Development of an intein-mediated split–Cas9 system for gene therapy
- (2015) Dong-Jiunn Jeffery Truong et al. NUCLEIC ACIDS RESEARCH
- ACD toxin-produced actin oligomers poison formin-controlled actin polymerization
- (2015) D. B. Heisler et al. SCIENCE
- A general purification platform for toxic proteins based on intein trans-splicing
- (2014) Changhua Shi et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Human Defensins Facilitate Local Unfolding of Thermodynamically Unstable Regions of Bacterial Protein Toxins
- (2014) Elena Kudryashova et al. IMMUNITY
- Intein Applications: From Protein Purification and Labeling to Metabolic Control Methods
- (2014) David W. Wood et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Limitations of Foxp3+ Treg depletion following viral infection in DEREG mice
- (2014) Allison F. Christiaansen et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Conditional protein splicing of α-sarcin in live cells
- (2014) Spencer C. Alford et al. Molecular BioSystems
- Thermodynamic properties of the effector domains of MARTX toxins suggest their unfolding for translocation across the host membrane
- (2014) Elena Kudryashova et al. MOLECULAR MICROBIOLOGY
- Faster Protein Splicing with theNostoc punctiformeDnaE Intein Using Non-native Extein Residues
- (2013) Manoj Cheriyan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Complementation of the Catalytic Domain of Pseudomonas Exotoxin A
- (2013) Erin L. Boland et al. JOURNAL OF MOLECULAR BIOLOGY
- Extein Residues Play an Intimate Role in the Rate-Limiting Step of Protein Trans-Splicing
- (2013) Neel H. Shah et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Naturally Split Inteins Assemble through a “Capture and Collapse” Mechanism
- (2013) Neel H. Shah et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Unique Features of the Anti-parallel, Heterodimeric Coiled-coil Interaction between Methyl-cytosine Binding Domain 2 (MBD2) Homologues and GATA Zinc Finger Domain Containing 2A (GATAD2A/p66α)
- (2012) Ninad M. Walavalkar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotides
- (2012) R. L. Juliano et al. JOURNAL OF DRUG TARGETING
- In-Cell Fluorescence Activation and Labeling of Proteins Mediated by FRET-Quenched Split Inteins
- (2012) Radhika Borra et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Impairment of podocyte function by diphtheria toxin—a new reversible proteinuria model in mice
- (2012) Andreas Goldwich et al. LABORATORY INVESTIGATION
- Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen
- (2012) Andrew J. McCluskey et al. Molecular Oncology
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- A tunable zinc finger-based framework for Boolean logic computation in mammalian cells
- (2012) Jason J. Lohmueller et al. NUCLEIC ACIDS RESEARCH
- Glutamyl Phosphate Is an Activated Intermediate in Actin Crosslinking by Actin Crosslinking Domain (ACD) Toxin
- (2012) Elena Kudryashova et al. PLoS One
- Changing the Receptor Specificity of Anthrax Toxin
- (2012) A. Mechaly et al. mBio
- Intersectional Cre Driver Lines Generated Using Split-Intein Mediated Split-Cre Reconstitution
- (2012) Ping Wang et al. Scientific Reports
- The naturally splitNpuDnaE intein exhibits an extraordinarily high rate in the proteintrans-splicing reaction
- (2009) Joachim Zettler et al. FEBS LETTERS
- Site-Specific Two-Color Protein Labeling for FRET Studies Using Split Inteins
- (2009) Jin-Yi Yang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- SUnSET, a nonradioactive method to monitor protein synthesis
- (2009) Enrico K Schmidt et al. NATURE METHODS
- Protein Trans-Splicing as a Means for Viral Vector-Mediated In Vivo Gene Therapy
- (2008) Juan Li et al. HUMAN GENE THERAPY
- Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin
- (2008) D. S. Kudryashov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search