Plants as Factories for Human Pharmaceuticals: Applications and Challenges

Extraction and downstream processing of plant-derived recombinant proteins

(2015) J.F. Buyel et al.   BIOTECHNOLOGY ADVANCES

Bringing plant-based veterinary vaccines to market: Managing regulatory and commercial hurdles

(2015) Jacqueline MacDonald et al.   BIOTECHNOLOGY ADVANCES

Prevention of allergic conjunctivitis in mice by a rice-based edible vaccine containing modified Japanese cedar pollen allergens

(2015) Ken Fukuda et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Molecular farming on rescue of pharma industry for next generations

(2015) Khaled Moustafa et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

High-value products from plants: the challenges of process optimization

(2015) Rainer Fischer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Means to optimize protein expression in transgenic plants

(2015) Kristian K Ullrich et al.   CURRENT OPINION IN BIOTECHNOLOGY

Plant-made pharmaceuticals: from ‘Edible Vaccines’ to Ebola therapeutics

(2015) Charles Arntzen   PLANT BIOTECHNOLOGY JOURNAL

Large-scale production of pharmaceutical proteins in plant cell culture-the protalix experience

(2015) Yoram Tekoah et al.   PLANT BIOTECHNOLOGY JOURNAL

From gene to harvest: insights into upstream process development for the GMP production of a monoclonal antibody in transgenic tobacco plants

(2015) Markus Sack et al.   PLANT BIOTECHNOLOGY JOURNAL

Moss-made pharmaceuticals: from bench to bedside

(2015) Ralf Reski et al.   PLANT BIOTECHNOLOGY JOURNAL

Commercial-scale biotherapeutics manufacturing facility for plant-made pharmaceuticals

(2015) Barry R. Holtz et al.   PLANT BIOTECHNOLOGY JOURNAL

When plant virology metAgrobacterium: the rise of the deconstructed clones

(2015) Hadrien Peyret et al.   PLANT BIOTECHNOLOGY JOURNAL

A juice extractor can simplify the downstream processing of plant-derived biopharmaceutical proteins compared to blade-based homogenizers

(2015) J.F. Buyel et al.   PROCESS BIOCHEMISTRY

Extracellular peptidase hunting for improvement of protein production in plant cells and roots

(2015) Jérôme Lallemand et al.   Frontiers in Plant Science

Characterization of protein N-glycosylation by tandem mass spectrometry using complementary fragmentation techniques

(2015) Kristina L. Ford et al.   Frontiers in Plant Science

Plant Molecular Pharming for the Treatment of Chronic and Infectious Diseases

(2014) Eva Stoger et al.   Annual Review of Plant Biology

Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200-L orbitally-shaken disposable bioreactor

(2014) Nicole Raven et al.   BIOTECHNOLOGY AND BIOENGINEERING

Recombinant plant-derived pharmaceutical proteins: current technical and economic bottlenecks

(2014) Maite Sabalza et al.   BIOTECHNOLOGY LETTERS

Expression of cholera toxin B subunit-lumbrokinase in edible sunflower seeds-the use of transmucosal carrier to enhance its fusion protein's effect on protection of rats and mice against thrombosis

(2014) Chunfeng Guan et al.   BIOTECHNOLOGY PROGRESS

Ectopic expression of human acidic fibroblast growth factor 1 in the medicinal plant, Salvia miltiorrhiza, accelerates the healing of burn wounds

(2014) YaQing Tan et al.   BMC BIOTECHNOLOGY

Transient expressions of synthetic biology in plants

(2014) Frank Sainsbury et al.   CURRENT OPINION IN PLANT BIOLOGY

Immunological aspects of using plant cells as delivery vehicles for oral vaccines

(2014) Sergio Rosales-Mendoza et al.   Expert Review of Vaccines

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

(2014) Xiangguo Qiu et al.   NATURE

Oral immunization of haemaggulutinin H5 expressed in plant endoplasmic reticulum with adjuvant saponin protects mice against highly pathogenic avian influenza A virus infection

(2014) Goeun Lee et al.   PLANT BIOTECHNOLOGY JOURNAL

Transgenic rice endosperm as a bioreactor for molecular pharming

(2014) Jiquan Ou et al.   PLANT CELL REPORTS

An Env-derived multi-epitope HIV chimeric protein produced in the moss Physcomitrella patens is immunogenic in mice

(2014) Lucía Orellana-Escobedo et al.   PLANT CELL REPORTS

The search for a promising cell factory system for production of edible vaccine

(2014) Abolfazl Barzegari et al.   Human Vaccines & Immunotherapeutics

Protein N-glycosylation in eukaryotic microalgae and its impact on the production of nuclear expressed biopharmaceuticals

(2014) Elodie Mathieu-Rivet et al.   Frontiers in Plant Science

Plant glyco-biotechnology on the way to synthetic biology

(2014) Andreas Loos et al.   Frontiers in Plant Science

Microalgae for high-value compounds and biofuels production: A review with focus on cultivation under stress conditions

(2013) Giorgos Markou et al.   BIOTECHNOLOGY ADVANCES

Glycosylation: impact, control and improvement during therapeutic protein production

(2013) Ana Rita Costa et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Risk Assessment and Regulation of Molecular Farming - A Comparison between Europe and US

(2013) Penelope Sparrow et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Farming of Pharmaceutical Proteins Using Plant Suspension Cell and Tissue Cultures

(2013) Stefan Schillberg et al.   CURRENT PHARMACEUTICAL DESIGN

Recombinant Protein Production of Earthworm Lumbrokinase for Potential Antithrombotic Application

(2013) Kevin Yueju Wang et al.   Evidence-based Complementary and Alternative Medicine

Expression of biologically active anti-thrombosis protein lumbrokinase in edible sunflower seed kernel

(2013) Chunfeng Guan et al.   JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY

Accumulation of secreted antibodies in plant cell cultures varies according to the isotype, host species and culture conditions

(2013) Bertrand Magy et al.   PLANT BIOTECHNOLOGY JOURNAL

Advances in genetic engineering of marine algae

(2012) Song Qin et al.   BIOTECHNOLOGY ADVANCES

Glyco-engineering in plants to produce human-like N-glycan structures

(2012) Alexandra Castilho et al.   Biotechnology Journal

Using storage organelles for the accumulation and encapsulation of recombinant proteins

(2012) Imran Khan et al.   Biotechnology Journal

Expression of GA733-Fc Fusion Protein as a Vaccine Candidate for Colorectal Cancer in Transgenic Plants

(2012) Zhe Lu et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Correlation of ADCC activity with cytokine release induced by the stably expressed, glyco-engineered humanized Lewis Y-specific monoclonal antibody MB314

(2012) Ralf Kircheis et al.   mAbs

First plant-made biologic approved

(2012) Jeffrey L Fox   NATURE BIOTECHNOLOGY

A chloroplast-derived C4V3 polypeptide from the human immunodeficiency virus (HIV) is orally immunogenic in mice

(2012) Néstor Rubio-Infante et al.   PLANT MOLECULAR BIOLOGY

Bioreactor systems for in vitro production of foreign proteins using plant cell cultures

(2011) Ting-Kuo Huang et al.   BIOTECHNOLOGY ADVANCES

Recovery and purification of plant-made recombinant proteins

(2011) Lisa R. Wilken et al.   BIOTECHNOLOGY ADVANCES

Plant-made pharmaceuticals: Leading products and production platforms

(2011) Matthew Paul et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Microalgae as platforms for production of recombinant proteins and valuable compounds: progress and prospects

(2011) Yangmin Gong et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana

(2011) Waranyoo Phoolcharoen et al.   PLANT BIOTECHNOLOGY JOURNAL

High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system

(2010) Zhong Huang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Plant-specific glycosylation patterns in the context of therapeutic protein production

(2010) Véronique Gomord et al.   PLANT BIOTECHNOLOGY JOURNAL

Seed-based expression systems for plant molecular farming

(2010) Joseph Boothe et al.   PLANT BIOTECHNOLOGY JOURNAL

Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody

(2009) Doreen M. Floss et al.   PLANT BIOTECHNOLOGY JOURNAL

Strategies to facilitate transgene expression in Chlamydomonas reinhardtii

(2009) Alke Eichler-Stahlberg et al.   PLANTA

Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens

(2009) Aldwin Anterola et al.   TRANSGENIC RESEARCH

Evaluation by double-blind placebo-controlled oral challenge of the clinical relevance of IgE antibodies against plant glycans

(2008) A. Mari et al.   ALLERGY

Down-regulated expression of plant-specific glycoepitopes in alfalfa

(2008) Christophe Sourrouille et al.   PLANT BIOTECHNOLOGY JOURNAL

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL

Comparison of Transient Protein Expression in Tobacco Leaves and Plant Suspension Culture

(2005) Lauren B. Andrews et al.   BIOTECHNOLOGY PROGRESS