Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions

(2021) Parker J. Nichols et al.   Nature Communications

RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

(2021) Jung In Kim et al.   PLoS Genetics

Adenosine-to-inosine RNA editing in the immune system: friend or foe?

(2020) Taisuke Nakahama et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Investigating RNA editing in deep transcriptome datasets with REDItools and REDIportal

(2020) Claudio Lo Giudice et al.   Nature Protocols

A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing

(2020) Pedro Henrique Costa Cruz et al.   RNA

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development

(2020) Sannula Kesavardhana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

(2020) Michael Devos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways

(2020) Tuangtong Vongpipatana et al.   JOURNAL OF IMMUNOLOGY

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

(2020) Huipeng Jiao et al.   NATURE

What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs

(2020) Jacki E. Heraud-Farlow et al.   Open Biology

Mendelian disease caused by variants affecting recognition of Z-DNA and Z-RNA by the Zα domain of the double-stranded RNA editing enzyme ADAR

(2019) Alan Herbert   EUROPEAN JOURNAL OF HUMAN GENETICS

A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing

(2019) Konstantin Licht et al.   GENOME RESEARCH

Astrocytes, an active player in Aicardi-Goutières syndrome

(2018) Sunetra Sase et al.   BRAIN PATHOLOGY

RNA editing in nascent RNA affects pre-mRNA splicing

(2018) Yun-Hua Esther Hsiao et al.   GENOME RESEARCH

ADAR1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity

(2018) Taisuke Nakahama et al.   EMBO REPORTS

Thermodynamic Model for B-Z Transition of DNA Induced by Z-DNA Binding Proteins

(2018) Ae-Ree Lee et al.   MOLECULES

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

Complex regulation of ADAR-mediated RNA-editing across tissues

(2016) Melanie A. Huntley et al.   BMC GENOMICS

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis

(2016) Brian J. Liddicoat et al.   EXPERIMENTAL HEMATOLOGY

CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis

(2016) Kotaro Miyake et al.   Cell Reports

Characterization of human disease phenotypes associated with mutations inTREX1,RNASEH2A,RNASEH2B,RNASEH2C,SAMHD1,ADAR, andIFIH1

(2015) Yanick J. Crow et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

Phenotypic Variation in Aicardi–Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and Cytokine Release

(2015) Eloy Cuadrado et al.   JOURNAL OF IMMUNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

(2015) Nuala A. O'Leary et al.   NUCLEIC ACIDS RESEARCH

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

RNA rewriting, recoding, and rewiring in human disease

(2015) Maria Anna Zipeto et al.   TRENDS IN MOLECULAR MEDICINE

A genome-wide map of hyper-edited RNA reveals numerous new sites

(2014) Hagit T. Porath et al.   Nature Communications

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

(2013) L. Bazak et al.   GENOME RESEARCH

Identifying RNA editing sites using RNA sequencing data alone

(2013) Gokul Ramaswami et al.   NATURE METHODS

RADAR: a rigorously annotated database of A-to-I RNA editing

(2013) Gokul Ramaswami et al.   NUCLEIC ACIDS RESEARCH

Adenosine-to-inosine RNA editing and human disease

(2013) William Slotkin et al.   Genome Medicine

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Accurate identification of human Alu and non-Alu RNA editing sites

(2012) Gokul Ramaswami et al.   NATURE METHODS

Darned in 2013: inclusion of model organisms and linking with Wikipedia

(2012) Anmol M. Kiran et al.   NUCLEIC ACIDS RESEARCH

ViennaRNA Package 2.0

(2011) Ronny Lorenz et al.   Algorithms for Molecular Biology

Functions and Regulation of RNA Editing by ADAR Deaminases

(2010) Kazuko Nishikura   Annual Review of Biochemistry

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in aicardi-Goutières syndrome

(2008) Jane T. Van Heteren et al.   GLIA

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY

Determination of editors at the novel A-to-I editing positions

(2008) Yoshinori Nishimoto et al.   NEUROSCIENCE RESEARCH

Specificity of ADAR-mediated RNA editing in newly identified targets

(2008) E. M. Riedmann et al.   RNA

Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5′-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon

(2008) Cyril X. George et al.   VIROLOGY