Article
Microbiology
Jin Dai, Guanghui Yi, Asha A. Philip, John T. Patton
Summary: The interferon (IFN)-inducible 2 ',5 '-oligoadenylate synthetase (OAS)-RNase L pathway plays a critical role in antiviral immunity. This study discovered a novel strategy of inhibiting the OAS-RNase L pathway by the simian SA11 strain of rotavirus through its NSP1 protein.
Article
Fisheries
Ji Liu, Yixuan He, Yujia Miao, Chushan Dai, Jun Yan, Meiling Liu, Jun Zou, Hao Feng
Summary: In this study, two variants of RIG-I, bcRIG-Ia and bcRIG-Ib, were identified in black carp. Over-expression of bcRIG-Ib, but not bcRIG-Ia, induced the transcription of IFN promoter and improved antiviral activity. Site mutation analysis revealed that phenylalanine (F)-28 was crucial for bcRIG-Ib oligomerization and its mediated IFN signaling.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Oncology
V Moreno, E. Calvo, M. R. Middleton, F. Barlesi, C. Gaudy-Marqueste, A. Italiano, E. Romano, A. Marabelle, E. Chartash, K. Dobrenkov, H. Zhou, E. C. Connors, Y. Zhang, M. Wermke
Summary: This study evaluated the efficacy of MK-4621 as monotherapy and in combination with pembrolizumab. The results showed that MK-4621 had tolerable safety and modest antitumor activity in patients, but did not provide meaningful clinical benefit at the doses tested.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Immunology
Samiddha Banerjee, Aruna Pal, Abantika Pal, Subhas Chandra Mandal, Paresh Nath Chatterjee, Jayanta Kumar Chatterjee
Summary: The RIG-I gene plays a crucial role in parasitic immunity in infected sheep, particularly in binding with Haemonchus contortus. Studies suggest that sheep could be a valuable model organism for understanding the role of RIG-I in antiparasitic immunity in humans, based on genetic similarities with other livestock species.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Tianxu Li, Yanyan Ren, Tingting Zhang, Xinyu Zhai, Xiuyuan Wang, Jinchao Wang, Bin Xing, Runchun Miao, Ning Li, Liangmeng Wei
Summary: This study investigates the regulatory role of duLGP2 in the duck RIG-I-mediated antiviral innate immune signaling system. The results demonstrate that duLGP2 can suppress duRIG-I activation and enhance the production of inflammatory cytokines. These findings contribute to a better understanding of the regulatory networks of the antiviral innate immune system in ducks.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Yixuan He, Ji Liu, Yujia Miao, Meiling Liu, Hui Wu, Jun Xiao, Hao Feng
Summary: The study showed that LGP2 plays a positive role in regulating MDA5 and enhancing antiviral ability in black carp. It was also found that bcLGP2 interacts with bcRIG-Ib and leads to the degradation of bcRIG-Ib through ubiquitination and proteasome, thus attenuating its antiviral signaling.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Cell Biology
Xue Jiang, Yanping Xiao, Wen Hou, Jingge Yu, Tian-Sheng He, Liang-Guo Xu
Summary: Innate immunity is the first line of defense against infections. A study found that the RNA-binding protein ZFP36 acts as a positive regulator in antiviral innate immunity by promoting K63-linked ubiquitination of RIG-I. This finding improves our understanding of the activation mechanism of RIG-I.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Immunology
Zhenling Ma, Wenwen Zhang, Wenhui Fan, Yaru Wu, Menghao Zhang, Jun Xu, Wenqing Li, Lei Sun, Wenjun Liu, Wei Liu
Summary: This study revealed the critical role of FoxO1 as a negative regulator in RIG-I-triggered signaling, influencing type I interferon production by controlling multiple pathways, thereby affecting the antiviral immune response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Wei Liu, Zhenling Ma, Yaru Wu, Cui Yuan, Yanyan Zhang, Zeyang Liang, Yu Yang, Wenwen Zhang, Pengtao Jiao
Summary: This study reveals that MST4 acts as a negative regulator of type I interferon (IFN) production during viral immune responses. MST4 inhibits the production of type I IFN by competing with TRAF3 for binding to MAVS, thereby preventing the TRAF3/MAVS association. Additionally, MST4 promotes the degradation of MAVS through the interaction with the E3 ubiquitin ligase Smurf1 and the subsequent K48-linked ubiquitination of MAVS.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Microbiology
Zhihua Ren, Yueru Yu, Chaoxi Chen, Dingyong Yang, Ting Ding, Ling Zhu, Junliang Deng, Zhiwen Xu
Summary: Long noncoding RNAs can regulate viral replication by modulating glycolysis and antiviral immune responses. The mitochondrial antiviral signaling protein (MAVS) plays a crucial role in bridging the gap between antiviral immunity and glycolysis, while lactate production can impair the antiviral immune response. LncRNAs also regulate antiviral innate immunity by interfering with RIG-I and downstream signaling pathways.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Lara S. U. Schwab, Rubaiyea Farrukee, Jean Francois Eleouet, Marie Anne Rameix-Welti, Sarah L. Londrigan, Andrew G. Brooks, Aeron C. Hurt, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C. Reading
Summary: This study demonstrates that pretreatment of human, mouse, or ferret airway cell lines, as well as intravenous injection of mice and ferrets, with a synthetic retinoic acid-inducible gene I agonist resulted in reduced susceptibility to subsequent respiratory syncytial virus infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cell Biology
James M. Burke
Summary: In response to viral infection, mammalian cells activate innate immune pathways to inhibit viral gene expression and promote the assembly of specific ribonucleoprotein complexes, thereby enhancing cell survival and antiviral signaling.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Biochemistry & Molecular Biology
Tomoh Matsumiya, Yuko Shiba, Jiangli Ding, Shogo Kawaguchi, Kazuhiko Seya, Tadaatsu Imaizumi
Summary: The study reveals that RIG-I and PKR have coordinated roles in inducing the expression of interferons (IFNs). PKR triggers stress granule formation through an antiviral stress response but does not sequester IFN-beta mRNA in these granules. Despite PKR-mediated translational silencing, some proteins, including IFN-beta, are still translated. This study suggests that RIG-I mainly responds to the expression of IFN-beta in cells with non-self dsRNA, and PKR negatively regulates IFN-beta protein expression induced by RIG-I signaling. This highlights the essential role of PKR in fine-tuning IFN-beta expression in RIG-I-mediated antiviral immune responses.
Article
Gastroenterology & Hepatology
Chi-Ling Chen, Tai-Chung Tseng, Chun-Jen Liu, Jia-Horng Kao, Pei-Jer Chen, Wei-Shiung Yang
Summary: This study reveals a positive relationship between serum RNase L levels and HBV viral titers or advanced disease status. Further investigation in this area may provide more details of an innate immune response for HBV and opportunity for novel therapeutic strategy.
HEPATOLOGY RESEARCH
(2023)
Article
Immunology
Alessandra Zevini, Enrico Palermo, Daniele Di Carlo, Magdalini Alexandridi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzola, Marilena P. Etna, Eliana M. Coccia, David Olagnier, John Hiscott
Summary: Dendritic cells play a crucial role in adaptive immune responses. This study reveals that activation of the RIG-I pathway induces metabolic reprogramming in dendritic cells, including increased glycolysis. Inhibition of glycolysis impairs the antiviral activity of dendritic cells and enhances viral replication. These findings highlight the importance of metabolic changes in dendritic cell activation and their impact on antiviral defense.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cell Biology
Yuri Uemura, Takuya Oshima, Munetaka Yamamoto, Charles Jourdan Reyes, Pedro Henrique Costa Cruz, Toshiharu Shibuya, Yukio Kawahara
Article
Chemistry, Multidisciplinary
Takuya Oshima, Kensuke Ishiguro, Tsutomu Suzuki, Yukio Kawahara
CHEMICAL COMMUNICATIONS
(2018)
Article
Immunology
Tuangtong Vongpipatana, Taisuke Nakahama, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara
JOURNAL OF IMMUNOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Taisuke Nakahama, Yukio Kawahara
Summary: ADAR1 is an enzyme responsible for RNA editing, with the Z alpha domain in its p150 isoform playing a critical role in preventing MDA5 activation. Studies on mutant mice have shown that mutations in the Z alpha domain can lead to AGS-like encephalopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Maal Inoue, Taisuke Nakahama, Ryuichiro Yamasaki, Toshiharu Shibuya, Jung In Kim, Hiroyuki Todo, Yanfang Xing, Yuki Kato, Eiichi Morii, Yukio Kawahara
Summary: Aicardi-Goutieres syndrome (AGS) is a rare inflammatory genetic disorder, and a study established a mouse model with an AGS-causative mutation. These mice showed inflammatory lesions in multiple organs like liver, spleen, and heart, as well as white matter abnormalities, among other pathological features.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Reiichi Sugihara, Yuki Kato, Tomoya Mori, Yukio Kawahara
Summary: Global alignment of complex pseudotime trajectories between different single-cell RNA-seq datasets is challenging. The authors present a computational method called CAPITAL to compare branching trajectories and demonstrate that it achieves accurate and robust alignments.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Taisuke Nakahama, Yukio Kawahara
Summary: ADAR1 is an RNA-editing enzyme that catalyzes adenosine-to-inosine conversions in dsRNAs. The p150 isoform of ADAR1 prevents MDA5 sensing of endogenous dsRNAs through its Zα domain and RNA-editing activity. ADAR1 also prevents ZBP1 sensing of Z-RNA and PKR sensing of right-handed dsRNAs.
INTERNATIONAL IMMUNOLOGY
(2023)