The gate to metastasis: key players in cancer cell intravasation

Adipocyte-induced FABP4 expression in ovarian cancer cells promotes metastasis and mediates carboplatin resistance

(2020) Abir Mukherjee et al.   CANCER RESEARCH

The use of mixed collagen-Matrigel matrices of increasing complexity recapitulates the biphasic role of cell adhesion in cancer cell migration: ECM sensing, remodeling and forces at the leading edge of cancer invasion

(2020) María Anguiano et al.   PLoS One

Pericyte dysfunction due to Shb gene deficiency increases B16F10 melanoma lung metastasis

(2020) Qi He et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Cancer-associated adipocytes: emerging supporters in breast cancer

(2020) Chongru Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

(2020) Linbin Yang et al.   NATURE

Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target

(2020) Joseph W. Franses et al.   Nature Communications

Chemotherapy-induced release of circulating-tumor cells into the bloodstream in collective migration units with cancer-associated fibroblasts in metastatic cancer patients

(2020) Nerymar Ortiz-Otero et al.   BMC CANCER

Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications

(2020) Qinyao Wei et al.   ONCOGENE

Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells

(2020) Cinzia Donato et al.   Cell Reports

Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding

(2019) Sofia Gkountela et al.   CELL

Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment

(2019) Luke Bu et al.   ONCOGENE

Neutrophils escort circulating tumour cells to enable cell cycle progression

(2019) Barbara Maria Szczerba et al.   NATURE

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

(2019) Ilaria Elia et al.   NATURE

The Warburg metabolism fuels tumor metastasis

(2019) Jianrong Lu   CANCER AND METASTASIS REVIEWS

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

(2019) Luca Lignitto et al.   CELL

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

(2019) Clotilde Wiel et al.   CELL

Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling

(2019) Anthony J. Berger et al.   MATRIX BIOLOGY

Tumour-associated neutrophils in patients with cancer

(2019) Merav E. Shaul et al.   Nature Reviews Clinical Oncology

Neutrophils as a Therapeutic Target in Cancer

(2019) Zvi Granot   Frontiers in Immunology

E-cadherin is required for metastasis in multiple models of breast cancer

(2019) Veena Padmanaban et al.   NATURE

Are 90% of deaths from cancer caused by metastases?

(2019) Hanna Dillekås et al.   Cancer Medicine

Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis

(2019) Yinying Dong et al.   Journal of Hematology & Oncology

Tumor Microenvironment of Metastasis (TMEM) Doorways Are Restricted to the Blood Vessel Endothelium in Both Primary Breast Cancers and Their Lymph Node Metastases

(2019) Ginter et al.   Cancers

YAP/TAZ Related BioMechano Signal Transduction and Cancer Metastasis

(2019) Bridget Martinez et al.   Frontiers in Cell and Developmental Biology

Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements

(2019) Vaishali Aggarwal et al.   Biomolecules

RNA-Seq of Circulating Tumor Cells in Stage II–III Breast Cancer

(2018) Julie E. Lang et al.   ANNALS OF SURGICAL ONCOLOGY

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

Matrix stiffening and EGFR cooperate to promote the collective invasion of cancer cells.

(2018) Eloise M Grasset et al.   CANCER RESEARCH

Involvement of partial EMT in cancer progression

(2018) Masao Saitoh   JOURNAL OF BIOCHEMISTRY

Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation

(2018) Xiao-xue Li et al.   MOLECULAR CELL

Macrophages orchestrate breast cancer early dissemination and metastasis

(2018) Nina Linde et al.   Nature Communications

Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins

(2018) Maomao Zhang et al.   Cancer Discovery

Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas

(2018) Kevin K. Chang et al.   Oncogenesis

Abstract 3688: A novel biomarker for pancreatic cancer, sTRA, and CA19-9 define separate subpopulations of PDAC cells with distinctions in behavior and molecular characteristics

(2018) Daniel Barnett et al.   CANCER RESEARCH

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

(2018) Kevin D. Courtney et al.   Cell Metabolism

The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies

(2018) Joaquín Araos et al.   CLINICAL & EXPERIMENTAL METASTASIS

Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review

(2018) Bashar Emon et al.   Computational and Structural Biotechnology Journal

Obesity and cancer risk: Emerging biological mechanisms and perspectives

(2018) Konstantinos I. Avgerinos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

CD36 plays a critical role in proliferation, migration and tamoxifen-inhibited growth of ER-positive breast cancer cells

(2018) Yu Liang et al.   Oncogenesis

Human colorectal cancer progression correlates with LOX-induced ECM stiffening

(2017) Bo Wei et al.   International Journal of Biological Sciences

Dual role of pericyte α6β1-integrin in tumour blood vessels

(2017) Louise E. Reynolds et al.   JOURNAL OF CELL SCIENCE

Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming

(2017) Lin Tian et al.   NATURE

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oxidative Stress: Harms and Benefits for Human Health

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Expression of Hypoxia-Associated Protein HIF-1α in Follicular Thyroid Cancer is Associated with Distant Metastasis

(2017) Aumayr Klaus et al.   PATHOLOGY & ONCOLOGY RESEARCH

Obesity and melanoma: could fat be fueling malignancy?

(2017) Emily Clement et al.   Pigment Cell & Melanoma Research

Intratumoral Cancer Cell Intravasation Can Occur Independent of Invasion into the Adjacent Stroma

(2017) Elena I. Deryugina et al.   Cell Reports

Investigation of Pericytes, Hypoxia, and Vascularity in Bladder Tumors: Association With Clinical Outcomes

(2017) Martina B. O'Keeffe et al.   ONCOLOGY RESEARCH

The role of platelets in the tumor microenvironment: From solid tumors to leukemia

(2016) MengJie Yan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hexokinase 2 is a determinant of neuroblastoma metastasis

(2016) Liat Edry Botzer et al.   BRITISH JOURNAL OF CANCER

Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer

(2016) Ikrame Lazar et al.   CANCER RESEARCH

Endosialin-Expressing Pericytes Promote Metastatic Dissemination

(2016) Carmen Viski et al.   CANCER RESEARCH

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?

(2016) Maren Diepenbruck et al.   CURRENT OPINION IN CELL BIOLOGY

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis

(2016) Chi Luo et al.   NATURE

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

(2016) Veronica Torrano et al.   NATURE CELL BIOLOGY

Pericyte–fibroblast transition promotes tumor growth and metastasis

(2016) Kayoko Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How neutrophils promote metastasis

(2016) T. Tuting et al.   SCIENCE

Genome-wide methylation sequencing of paired primary and metastatic cell lines identifies common DNA methylation changes and a role for EBF3 as a candidate epigenetic driver of melanoma metastasis

(2016) Aniruddha Chatterjee et al.   Oncotarget

Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer

(2016) Marybeth Anderson et al.   Oncotarget

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(2016) Evelyne Beerling et al.   Cell Reports

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

(2016) Marie-Julie Nokin et al.   eLife

Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers

(2016) Aritro Nath et al.   Scientific Reports

Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/MenaINV-initiated invadopodium formation

(2016) Jeanine Pignatelli et al.   Scientific Reports

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

(2015) Valéry L. Payen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The relevance of EMT in breast cancer metastasis: Correlation or causality?

(2015) Ruben Bill et al.   FEBS LETTERS

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers

(2015) Yoshinaga Okugawa et al.   GASTROENTEROLOGY

Knockdown of PKM2 Suppresses Tumor Growth and Invasion in Lung Adenocarcinoma

(2015) Hong Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

(2015) Stefanie K. Wculek et al.   NATURE

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR

(2015) Miguel Vizoso et al.   NATURE MEDICINE

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Stem-Cell-like Properties and Epithelial Plasticity Arise as Stable Traits after Transient Twist1 Activation

(2015) Johanna M. Schmidt et al.   Cell Reports

Targeting Vascular Pericytes in Hypoxic Tumors Increases Lung Metastasis via Angiopoietin-2

(2015) Doruk Keskin et al.   Cell Reports

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma

(2015) Wei-Ren Liu et al.   Oncotarget

Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression

(2015) Ang Yuan et al.   Scientific Reports

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

(2014) H. D. Tran et al.   CANCER RESEARCH

Targeting Mitochondrial Oxidative Metabolism in Melanoma Causes Metabolic Compensation through Glucose and Glutamine Utilization

(2014) J.-H. Lim et al.   CANCER RESEARCH

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

HIF2α is associated with poor prognosis and affects the expression levels of survivin and cyclin D1 in gastric carcinoma

(2014) WEI-WEI TONG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer

(2014) Jens G Lohr et al.   NATURE BIOTECHNOLOGY

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Cancer Stem Cell-Specific Scavenger Receptor CD36 Drives Glioblastoma Progression

(2014) James S. Hale et al.   STEM CELLS

Isolation and Molecular Characterization of Circulating Melanoma Cells

(2014) Xi Luo et al.   Cell Reports

Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells

(2014) David T. Ting et al.   Cell Reports

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Tumor Interstitial Fluid Pressure—A Link between Tumor Hypoxia, Microvascular Density, and Lymph Node Metastasis

(2014) Einar K. Rofstad et al.   NEOPLASIA

Interstitial fluid flow in cancer: implications for disease progression and treatment

(2014) Jennifer Munson et al.   Cancer Management and Research

Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids

(2013) Sharon M. Louie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Complex Tumor Genomes Inferred from Single Circulating Tumor Cells by Array-CGH and Next-Generation Sequencing

(2013) E. Heitzer et al.   CANCER RESEARCH

Adipocyte and adipogenesis

(2013) Aus Tariq Ali et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

(2013) Jie Hu et al.   NATURE BIOTECHNOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation

(2013) M Roh-Johnson et al.   ONCOGENE

Size-Based Isolation of Circulating Tumor Cells in Lung Cancer Patients Using a Microcavity Array System

(2013) Masahito Hosokawa et al.   PLoS One

Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients

(2013) X. Ni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

(2012) Vesselina G. Cooke et al.   CANCER CELL

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Interstitial Fluid Pressure and Associated Lymph Node Metastasis Revealed in Tumors by Dynamic Contrast-Enhanced MRI

(2012) T. Hompland et al.   CANCER RESEARCH

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity

(2012) Y. Kim et al.   GENES & DEVELOPMENT

Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells

(2012) Cheng-Fu Zhou et al.   IUBMB LIFE

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

(2012) Toni Celià-Terrassa et al.   JOURNAL OF CLINICAL INVESTIGATION

New Insight into the SDF-1/CXCR4 Axis in a Breast Carcinoma Model: Hypoxia-Induced Endothelial SDF-1 and Tumor Cell CXCR4 Are Required for Tumor Cell Intravasation

(2012) F. Jin et al.   MOLECULAR CANCER RESEARCH

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

(2012) Min Yu et al.   NATURE

Independent regulation of tumor cell migration by matrix stiffness and confinement

(2012) A. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-Recruited Neutrophils and Neutrophil TIMP-Free MMP-9 Regulate Coordinately the Levels of Tumor Angiogenesis and Efficiency of Malignant Cell Intravasation

(2011) Erin M. Bekes et al.   AMERICAN JOURNAL OF PATHOLOGY

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer

(2011) Q. Chang et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

DNA Methylation of Tumor Suppressor and Metastasis Suppressor Genes in Circulating Tumor Cells

(2011) M. Chimonidou et al.   CLINICAL CHEMISTRY

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

(2011) Wei Tan et al.   NATURE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

(2011) H Zhang et al.   ONCOGENE

VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization

(2011) J. T. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Malignant cells facilitate lung metastasis by bringing their own soil

(2010) D. G. Duda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Endosialin (Tem1) Is a Marker of Tumor-Associated Myofibroblasts and Tumor Vessel-Associated Mural Cells

(2008) Sven Christian et al.   AMERICAN JOURNAL OF PATHOLOGY

Endosialin (CD248) is a marker of tumor-associated pericytes in high-grade glioma

(2008) Nicole Simonavicius et al.   MODERN PATHOLOGY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE