The specification and function of enteroendocrine cells in Drosophila and mammals: a comparative review

The Neosartorya fischeri Antifungal Protein 2 (NFAP2): A New Potential Weapon against Multidrug-Resistant Candida auris Biofilms

(2021) Renátó Kovács et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis

(2021) Chen Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Organelles in Intestinal Function, Physiology, and Disease

(2021) Siamak Redhai et al.   TRENDS IN CELL BIOLOGY

A cell atlas of the adult Drosophila midgut

(2020) Ruei-Jiun Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut dysbiosis and serotonin: intestinal 5-HT as a ubiquitous membrane permeability regulator in host tissues, organs, and the brain

(2020) Henrik Szőke et al.   REVIEWS IN THE NEUROSCIENCES

A Switch in Tissue Stem Cell Identity Causes Neuroendocrine Tumors in Drosophila Gut

(2020) Zhaohui Li et al.   Cell Reports

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

(2020) Joep Beumer et al.   CELL

Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis

(2020) Wenju Chang et al.   Cell Stem Cell

The gut–brain axis mediates sugar preference

(2020) Hwei-Ee Tan et al.   NATURE

Glucagon-Like Peptide-1 Secreting L-Cells Coupled to Sensory Nerves Translate Microbial Signals to the Host Rat Nervous System

(2020) Maria M. Buckley et al.   Frontiers in Cellular Neuroscience

Role of Gut Microbiota in Neuroendocrine Regulation of Carbohydrate and Lipid Metabolism via the Microbiota-Gut-Brain-Liver Axis

(2020) Shu-Zhi Wang et al.   Microorganisms

RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis

(2020) Erika Sugisawa et al.   CELL

Vagal sensory neurons and gut-brain signaling

(2020) Chuyue D Yu et al.   CURRENT OPINION IN NEUROBIOLOGY

Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells

(2020) Ming Zhao et al.   Cell Reports

Role of an active reserve stem cell subset of enteroendocrine cells in intestinal stem cell dynamics and the genesis of small intestinal neuroendocrine tumors

(2020) Yoshitatsu Sei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cell fate specification and differentiation in the adult mammalian intestine

(2020) Joep Beumer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways

(2020) Lihua Ye et al.   Cell Host & Microbe

Obesity alters adrenergic and chemosensory signaling pathways that regulate ghrelin secretion in the human gut

(2019) Qiaoling Wang et al.   FASEB JOURNAL

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

(2019) Fiona M. Gribble et al.   Nature Reviews Endocrinology

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping

(2019) Helmuth Gehart et al.   CELL

The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release

(2019) Alyce M. Martin et al.   Frontiers in Physiology

Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition that Controls Intestinal Stem Cell Differentiation in Drosophila

(2019) Xingting Guo et al.   Stem Cell Reports

Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice

(2019) Youngmi Song et al.   Cell Metabolism

Mechanisms controlling hormone secretion in human gut and its relevance to metabolism

(2019) Alyce M Martin et al.   JOURNAL OF ENDOCRINOLOGY

The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine

(2019) Jerome Korzelius et al.   Nature Communications

Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production

(2019) Julie Piccand et al.   Molecular Metabolism

Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation

(2019) Xiaodan Liu et al.   DEVELOPMENTAL CELL

Enterochromaffin cell hyperplasia in the gut: Factors, mechanism and therapeutic clues

(2019) Hong-yan Qin et al.   LIFE SCIENCES

The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

(2019) Xingting Guo et al.   Cell Reports

High fat diet induces microbiota-dependent silencing of enteroendocrine cells

(2019) Lihua Ye et al.   eLife

Chemoreceptors in the Gut

(2018) S. Steensels et al.   Annual Review of Physiology

Parkinson’s disease from the gut

(2018) Rodger A. Liddle   BRAIN RESEARCH

The now and then of gut-brain signaling

(2018) Melanie M. Kaelberer et al.   BRAIN RESEARCH

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

(2018) Preeti Pathak et al.   HEPATOLOGY

Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

(2018) Li He et al.   NATURE

Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells

(2018) Jun Chen et al.   NATURE CELL BIOLOGY

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient

(2018) Joep Beumer et al.   NATURE CELL BIOLOGY

A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Cell Enteroendocrine Commitment in Drosophila

(2018) Chang Yin et al.   Stem Cell Reports

Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms

(2018) Kristoffer L. Egerod et al.   Molecular Metabolism

Dietary Lipids Modulate Notch Signaling and Influence Adult Intestinal Development and Metabolism in Drosophila

(2018) Rebecca Obniski et al.   DEVELOPMENTAL CELL

Serotonin, hematopoiesis and stem cells

(2018) Guillemette Fouquet et al.   PHARMACOLOGICAL RESEARCH

A gut-brain neural circuit for nutrient sensory transduction

(2018) Melanie Maya Kaelberer et al.   SCIENCE

SCFAs strongly stimulate PYY production in human enteroendocrine cells

(2018) P. Larraufie et al.   Scientific Reports

Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner

(2018) Tomotsune Ameku et al.   PLOS BIOLOGY

The DH31/CGRP enteroendocrine peptide triggers intestinal contractions favoring the elimination of opportunistic bacteria

(2018) Olivia Benguettat et al.   PLoS Pathogens

A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila

(2018) Alessandro Scopelliti et al.   Cell Metabolism

Sox4 Promotes Atoh1-Independent Intestinal Secretory Differentiation Toward Tuft and Enteroendocrine Fates

(2018) Adam D. Gracz et al.   GASTROENTEROLOGY

Diversity of enteroendocrine cells investigated at cellular and subcellular levels: the need for a new classification scheme

(2018) Linda J. Fothergill et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial

(2018) Juan Pablo Frias et al.   LANCET

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Dynamics of Gut-Brain Communication Underlying Hunger

(2017) Lisa R. Beutler et al.   NEURON

Drosophila Neuropeptide F Signaling Independently Regulates Feeding and Sleep-Wake Behavior

(2017) Brian Y. Chung et al.   Cell Reports

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

(2017) Lucy Brooks et al.   Molecular Metabolism

Cholecystokinin—From Local Gut Hormone to Ubiquitous Messenger

(2017) Jens F. Rehfeld   Frontiers in Endocrinology

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium

(2016) Fiona M. Gribble et al.   Annual Review of Physiology

Evolving Concepts and Translational Relevance of Enteroendocrine Cell Biology

(2016) Daniel J. Drucker   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Systematic Analysis of Drosophila Regulatory Peptide Expression in Enteroendocrine Cells

(2016)   MOLECULES AND CELLS

An obligatory role for neurotensin in high-fat-diet-induced obesity

(2016) Jing Li et al.   NATURE

High fat diet impairs the function of glucagon-like peptide-1 producing L-cells

(2016) Paul Richards et al.   PEPTIDES

Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer

(2016) Jana Jezkova et al.   Oncotarget

Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF

(2016) Jiangtian Chen et al.   PLoS Genetics

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages

(2015) Chenhui Wang et al.   DEVELOPMENT

Generation of enteroendocrine cell diversity in midgut stem cell lineages

(2015) R. Beehler-Evans et al.   DEVELOPMENT

Notch receptor regulation of intestinal stem cell homeostasis and crypt regeneration

(2015) Alexis J. Carulli et al.   DEVELOPMENTAL BIOLOGY

How informative is the mouse for human gut microbiota research?

(2015) T. L. A. Nguyen et al.   Disease Models & Mechanisms

Taste and move: glucose and peptide transporters in the gastrointestinal tract

(2015) Hannelore Daniel et al.   EXPERIMENTAL PHYSIOLOGY

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

(2015) Diego V. Bohórquez et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell messenger RNA sequencing reveals rare intestinal cell types

(2015) Dominic Grün et al.   NATURE

Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut

(2015) Devanjali Dutta et al.   Cell Reports

Of Fighting Flies, Mice, and Men: Are Some of the Molecular and Neuronal Mechanisms of Aggression Universal in the Animal Kingdom?

(2015) Amanda L. Thomas et al.   PLoS Genetics

Chemical identity, function and regulation of enteroendocrine peptides in insects

(2015) Christian Wegener et al.   Current Opinion in Insect Science

CCHamide-2 Is an Orexigenic Brain-Gut Peptide in Drosophila

(2015) Guilin R. Ren et al.   PLoS One

Role of free fatty acid receptors in the regulation of energy metabolism

(2014) Takafumi Hara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Local Control of Intestinal Stem Cell Homeostasis by Enteroendocrine Cells in the Adult Drosophila Midgut

(2014) Alessandro Scopelliti et al.   CURRENT BIOLOGY

The diabetes gene Hhex maintains  -cell differentiation and islet function

(2014) J. Zhang et al.   GENES & DEVELOPMENT

Motilin-induced gastric contractions signal hunger in man

(2014) J Tack et al.   GUT

Impact of high-fat feeding on basic helix–loop–helix transcription factors controlling enteroendocrine cell differentiation

(2014) Y Sakar et al.   INTERNATIONAL JOURNAL OF OBESITY

Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis

(2014) Conrad Eng et al.   LANCET

An Enteroendocrine Cell – Enteric Glia Connection Revealed by 3D Electron Microscopy

(2014) Diego V. Bohórquez et al.   PLoS One

Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine

(2014) Julian Heuberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila

(2014) Alla Amcheslavsky et al.   Cell Reports

Slit/Robo Signaling Regulates Cell Fate Decisions in the Intestinal Stem Cell Lineage of Drosophila

(2014) Benoît Biteau et al.   Cell Reports

Control of Lipid Metabolism by Tachykinin in Drosophila

(2014) Wei Song et al.   Cell Reports

Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling

(2014) Dick R. Nässel et al.   Frontiers in Endocrinology

The Digestive Tract ofDrosophila melanogaster

(2013) Bruno Lemaitre et al.   Annual Review of Genetics

Physiology and Pharmacology of the Enteroendocrine Hormone Glucagon-Like Peptide-2

(2013) Daniel J. Drucker et al.   Annual Review of Physiology

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

(2013) Anita Wichmann et al.   Cell Host & Microbe

Enteroendocrine secretion of gut hormones in diabetes, obesity and after bariatric surgery

(2013) Jens Juul Holst   CURRENT OPINION IN PHARMACOLOGY

Enteroendocrine cells in gastrointestinal pathophysiology

(2013) Elizabeth Harrison et al.   CURRENT OPINION IN PHARMACOLOGY

Enteroendocrine cell signalling via the vagus nerve

(2013) Graham J Dockray   CURRENT OPINION IN PHARMACOLOGY

Enteroendocrine cell types revisited

(2013) Maja S Engelstoft et al.   CURRENT OPINION IN PHARMACOLOGY

Gut hormones as therapeutic agents in treatment of diabetes and obesity

(2013) Tricia Tan et al.   CURRENT OPINION IN PHARMACOLOGY

Enteroendocrine hormones—central effects on behavior

(2013) Karolina P Skibicka et al.   CURRENT OPINION IN PHARMACOLOGY

Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine

(2013) Kara Gross Margolis et al.   GUT

Intestinal label-retaining cells are secretory precursors expressing Lgr5

(2013) Simon J. A. Buczacki et al.   NATURE

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

The gut as a sensory organ

(2013) John B. Furness et al.   Nature Reviews Gastroenterology & Hepatology

Expression Patterns of the Drosophila Neuropeptide CCHamide-2 and Its Receptor May Suggest Hormonal Signaling from the Gut to the Brain

(2013) Shizhong Li et al.   PLoS One

Molecular evolution of peptidergic signaling systems in bilaterians

(2013) O. Mirabeau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

(2013) Nicolas Buchon et al.   Cell Reports

Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation

(2012) Laurianne Van Landeghem et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets

(2012) P. Marchetti et al.   DIABETOLOGIA

Disruption of the MurineGlp2rImpairs Paneth Cell Function and Increases Susceptibility to Small Bowel Enteritis

(2012) Seung-Jun Lee et al.   ENDOCRINOLOGY

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

The Homeodomain-Containing Transcription Factors Arx and Pax4 Control Enteroendocrine Subtype Specification in Mice

(2012) Anthony Beucher et al.   PLoS One

GLP-2 enhances barrier formation and attenuates TNFα-induced changes in a Caco-2 cell model of the intestinal barrier

(2012) G.W. Moran et al.   REGULATORY PEPTIDES

GPR119 as a fat sensor

(2012) Harald S. Hansen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Diet: Friend or Foe of Enteroendocrine Cells: How It Interacts with Enteroendocrine Cells

(2012) Sofia Moran-Ramos et al.   Advances in Nutrition

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

(2011) K. L. VanDussen et al.   DEVELOPMENT

Postprandial Insulin Secretion After Gastric Bypass Surgery: The Role of Glucagon-Like Peptide 1

(2011) J. J. Holst   DIABETES

Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

(2011) V. Gorboulev et al.   DIABETES

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Loss of Incretin Effect Is a Specific, Important, and Early Characteristic of Type 2 Diabetes

(2011) J. J. Holst et al.   DIABETES CARE

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

Nutrient sensing receptors in gastric endocrine cells

(2011) Désirée Haid et al.   JOURNAL OF MOLECULAR HISTOLOGY

Peptidomics and Peptide Hormone Processing in theDrosophilaMidgut

(2011) Wencke Reiher et al.   JOURNAL OF PROTEOME RESEARCH

A comparative review of short and long neuropeptide F signaling in invertebrates: Any similarities to vertebrate neuropeptide Y signaling?

(2011) Dick R. Nässel et al.   PEPTIDES

Heterogeneous Expression of Drosophila Gustatory Receptors in Enteroendocrine Cells

(2011) Jeong-Ho Park et al.   PLoS One

A stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestine

(2010) Yoshitatsu Sei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pseudopod-like basal cell processes in intestinal cholecystokinin cells

(2010) Rashmi Chandra et al.   CELL AND TISSUE RESEARCH

Cell Lineage metastability in Gfi1-deficient mouse intestinal epithelium

(2010) Matthew Bjerknes et al.   DEVELOPMENTAL BIOLOGY

Neurotensin is a regulator of insulin secretion in pancreatic beta-cells

(2010) Sophie Béraud-Dufour et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The role of glucagon-like peptide-2 on apoptosis, cell proliferation, and oxidant–antioxidant system at a mouse model of intestinal injury induced by tumor necrosis factor-alpha/actinomycin D

(2010) Pelin Arda-Pirincci et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Drosophila neuropeptides in regulation of physiology and behavior

(2010) Dick R. Nässel et al.   PROGRESS IN NEUROBIOLOGY

Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium

(2009) Eric J. Formeister et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure

(2009) Vijay K. Yadav et al.   CELL

Foxa1 and Foxa2 Control the Differentiation of Goblet and Enteroendocrine L- and D-Cells in Mice

(2009) Diana Z. Ye et al.   GASTROENTEROLOGY

Release of 5-Hydroxytryptamine From the Mucosa Is Not Required for the Generation or Propagation of Colonic Migrating Motor Complexes

(2009) Damien J. Keating et al.   GASTROENTEROLOGY

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Suppression of p38 MAPK and JNK via Akt-mediated Inhibition of Apoptosis Signal-regulating Kinase 1 Constitutes a Core Component of the β-Cell Pro-survival Effects of Glucose-dependent Insulinotropic Polypeptide

(2009) Scott B. Widenmaier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism

Chromogranin A-, serotonin-, synaptophysin- and vascular endothelial growth factor-positive endocrine cells and the prognosis of colorectal cancer: An immunohistochemical and ultrastructural study

(2008) Maya Gulubova et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia

(2008) Stefan Bröer   PHYSIOLOGICAL REVIEWS