Article
Andrology
Sky Graybill, Jennifer Hatfield, Maria Kravchenko, Darrick Beckman, Joshua Tate, Alexis Beauvais, Philip Clerc, Desarae Davila, Whitney Forbes, Jana Wardian, Matthew Kemm, Abegail Hubberd, Mark True
Summary: This study found that GLP-1 RA therapy improved weight and HbA1c without adverse effects on testosterone levels. Patients with lower baseline testosterone values or greater improvements in HbA1c may see additional benefits.
Article
Integrative & Complementary Medicine
Li Qiang, Yang Qimeng, Han Jing, Liu Xiaohan, Fu Junjie, Yin Jian
Summary: Peptide dual agonists that target both GLP-1R and GCGR receptors have emerged as potential therapeutics for treating type 2 diabetes with obesity. O-GlcNAcylation was shown to improve the stability of a dual GLP-1R/GCGR agonist, leading to significant weight loss and hypoglycemic effects.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Pharmacology & Pharmacy
Songfeng Zhao, Zhiming Yan, Yue Du, Zeyun Li, Chunli Tang, Lin Jing, Lidan Sun, Qimeng Yang, Xueling Tang, Yongliang Yuan, Jing Han, Neng Jiang
Summary: This study demonstrates the therapeutic potential of dual agonists targeting GLP-1/glucagon and GLP-1/CCK2 receptors in the treatment of obesity and diabetes. The newly developed peptide, xGLP-1/GCG/gastrin, showed significant anti-diabetes and anti-obesity effects in both in vitro and in vivo experiments.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Neng Jiang, Lin Jing, Qing Li, Sibiao Su, Qimeng Yang, Feng Zhou, Xinyu Chen, Jing Han, Chunli Tang, Weizhong Tang
Summary: Dual activation of the glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R) can potentially lead to effective therapy for diabetes and obesity. Novel peptides with dual activity on GLP-1R and GCGR were discovered through rational design, with xGLP/GCG-15 showing promising anti-obesity and anti-diabetic effects in preclinical studies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Karan R. Chadda, Tuck Seng Cheng, Ken K. Ong
Summary: GLP-1 agonists show promising efficacy in treating children with obesity and/or T2DM, with positive effects on reducing HbA1c and body weight. Adverse effects mainly include gastrointestinal symptoms and minor hypoglycemic episodes.
Article
Nutrition & Dietetics
Sara Volpe, Giuseppe Lisco, Davide Racaniello, Margherita Fanelli, Valentina Colaianni, Alfredo Vozza, Vincenzo Triggiani, Carlo Sabba, Cosimo Tortorella, Giovanni De Pergola, Giuseppina Piazzolla
Summary: This study assessed the impact of Semaglutide on body composition in patients with type 2 diabetes. The results showed that Semaglutide significantly reduced body fat mass and body weight, with a lasting effect after three months of treatment. However, it had no significant effect on muscle strength and muscle quality.
Review
Endocrinology & Metabolism
Junaid Iqbal, Hui-Xuan Wu, Nan Hu, Ying-Hui Zhou, Long Li, Fen Xiao, Ting Wang, Hong-Li Jiang, Shi-Na Xu, Bi-Ling Huang, Hou-De Zhou
Summary: This study provides an up-to-date systematic review and meta-analysis on the overall weight loss effect of glucagon-like peptide-1 receptor agonists (GLP-1 RA) in adults with obesity and overweight without diabetes mellitus. The results show that GLP-1 RA leads to significant weight loss and improves glycemic control without increasing the risk of hypoglycemia. It also has positive effects on blood pressure and lipid levels.
Article
Biochemistry & Molecular Biology
Takayuki Masaki, Yoshinori Ozeki, Yuichi Yoshida, Mitsuhiro Okamoto, Shotaro Miyamoto, Koro Gotoh, Hirotaka Shibata
Summary: In obese type 2 diabetic patients, treatment with the GLP1-RA semaglutide resulted in improvements in body weight, HbA1c, and eating behavior, particularly in the sensation of hunger. The changes in hunger sensation were closely related to the improvement in HbA1c levels during treatment.
Article
Biochemistry & Molecular Biology
Shunming Zhang, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Xuena Wang, Juanjuan Zhang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Yan Borne, Emily Sonestedt, Le Ma, Lu Qi, Kaijun Niu
Summary: This study of Chinese adults found that higher intakes of total dairy, milk, and yogurt were associated with a lower risk of type 2 diabetes (T2D).
Article
Biochemistry & Molecular Biology
Shunming Zhang, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Xuena Wang, Juanjuan Zhang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Yan Borne, Emily Sonestedt, Le Ma, Lu Qi, Kaijun Niu
Summary: Higher intakes of total dairy, milk, and yogurt were all associated with a lower risk of T2D among Chinese adults.
Article
Endocrinology & Metabolism
Tetsuhiko Sato, Yoshinori Azuma, Chikafumi Ozone, Mikako Okazaki, Asami Takeda, Manabu Okada, Kenta Futamura, Takahisa Hiramitsu, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai
Summary: This retrospective cohort study found that the use of GLP-1 receptor agonists in type 2 diabetes patients after kidney transplantation was associated with a lower risk of sustained reduction in kidney function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Victoria E. R. Parker, Darren Robertson, Edmundo Erazo-Tapia, Bas Havekes, Esther Phielix, Marlies de Ligt, Kay H. M. Roumans, Julian Mevenkamp, Folke Sjoberg, Vera B. Schrauwen-Hinderling, Edvin Johansson, Yi-Ting Chang, Russell Esterline, Kenneth Smith, Daniel J. Wilkinson, Lars Hansen, Lars Johansson, Philip Ambery, Lutz Jermutus, Patrick Schrauwen
Summary: In a two-part randomized phase 2a trial in men and women with overweight or obesity and type 2 diabetes mellitus, cotadutide promoted greater reductions in liver glycogen and fat than placebo and liraglutide.
Article
Endocrinology & Metabolism
Ibiyemi Ilesanmi, George Tharakan, Kleopatra Alexiadou, Preeshila Behary, Haya Alessimii, Candace Bovill-Taylor, Julia Kenkre, Sirazum Choudhury, Chedie Doyle, Sanjay Purkayastha, Alex Miras, Christos Tsironis, Harvinder Chahal, Stephen R. Bloom, Nick S. Oliver, Ahmed R. Ahmed, Bernard Khoo, Tricia M. -M. Tan
Summary: This study showed that after RYGB surgery, patients experienced a decrease in mean glucose levels, an increase in glycemic variability, and an increase in GLP-1 response, which put them at risk for postbariatric hypoglycemia.
Review
Endocrinology & Metabolism
J. D. Watkins, S. Carter, G. Atkinson, F. Koumanov, J. A. Betts, J. J. Holst, J. T. Gonzalez
Summary: This systematic review aims to investigate the effect of type 2 diabetes (T2D) on GLP-1 secretion and explore potential moderators. The findings show that there is minimal and inconsistent difference in GLP-1 secretion between individuals with T2D and without T2D.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Review
Medicine, General & Internal
Han Chen, Xin-Zhu Li, Jia-Qing Chen, Tian-Shu Ren, Ying-Shi Zhang, Yi-Nuo Wang, Qing-Chun Zhao
Summary: This study conducted a network meta-analysis to evaluate the clinical efficacy and safety of 4 weekly formulations of GLP-1RAs. The results showed that the different doses of GLP-1RAs had differential glycemic control, with Semaglutide 2.0mg exhibiting the best performance in comprehensively lowering blood sugar.
Article
Obstetrics & Gynecology
Jean M. Donnelly, Karen Lindsay, Jennifer M. Walsh, Mary K. Horan, Donal O'Shea, Eleanor J. Molloy, Fionnuala M. McAuliffe
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2020)
Article
Immunology
Aisling O'Brien, Roisin M. Loftus, Marta M. Pisarska, Laura M. Tobin, Ronan Bergin, Nicole A. W. Wood, Cathriona Foley, Arimin Mat, Frances C. Tinley, Ciaran Bannan, Gary Sommerville, Natacha Veerapen, Gurdyal S. Besra, Linda Sinclair, Paul N. Moynagh, Lydia Lynch, David K. Finlay, Donal O'Shea, Andrew E. Hogan
JOURNAL OF IMMUNOLOGY
(2019)
Review
Oncology
Donal O'Shea, Andrew E. Hogan
Article
Medicine, General & Internal
Tomas Ahern, Emer O'Malley, Colin Dunlevy, Aftab Khattak, Helen O'Brien, Tidi Hassan, Tara Cusack, Walter T. McNicholas, Donal O'Shea
IRISH JOURNAL OF MEDICAL SCIENCE
(2020)
Letter
Dermatology
Barry Moran, Catriona Gallagher, Anne Marie Tobin, Jean M. Fletcher
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Eirini Giannoudaki, Yasmina E. Hernandez-Santana, Kelly Mulfaul, Sarah L. Doyle, Emily Hams, Padraic G. Fallon, Arimin Mat, Donal O'Shea, Manfred Kopf, Andrew E. Hogan, Patrick T. Walsh
NATURE COMMUNICATIONS
(2019)
Article
Nutrition & Dietetics
Simon Green, Catherine Kiely, Eamonn O'Connor, Norita Gildea, Donal O'Shea, Mikel Egana
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2020)
Article
Medicine, General & Internal
Dimitris Papamargaritis, Werd Al-Najim, Jonathan Lim, James Crane, Mike Lean, Carel Le Roux, Barbara McGowan, Donal O'Shea, David Webb, John Wilding, Melanie J. Davies
Review
Immunology
Marta M. Pisarska, Margaret R. Dunne, Donal O'Shea, Andrew E. Hogan
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Letter
Dermatology
C. Blake, H. Hadden, M. Dolan, M. Greenwood, M. O'Kane, D. McMahon, A. M. Tobin
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Siobhan McCarthy, Maurice Barrett, Shivashini Kirthi, Paola Pellanda, Klara Vlckova, Anne-Marie Tobin, Michelle Murphy, Fergus Shanahan, Paul W. O'Toole
Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by nodules, abscesses, and fistulae. This study found that individuals with HS had lower microbial diversity in fecal, skin, and nasal samples, and certain bacteria were more abundant. Finegoldia magna was overabundant in HS skin samples, potentially contributing to local inflammation. These findings suggest that the microbiome alterations in both the gut and skin of HS patients deserve further investigation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Letter
Dermatology
Claire Doyle, Orla McFeely, Paula Beatty, Lisa Murphy, Sarah O'Mahoney, Marta Costa Blasco, Madonna Andrawis, Anne-Marie Tobin
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Letter
Dermatology
Orla Mcfeely, Marta Costa Blasco, Anna Wolinska, Madonna Andrawis, Lisa Murphy, Anne-Marie Tobin
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Psychology, Clinical
Ourania Founta, Karoline Adamzik, Anne-Marie Tobin, Brian Kirby, David Hevey
JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS
(2019)
Meeting Abstract
Dermatology
C. O'Grady, F. Awdeh, A. -M. Tobin
EXPERIMENTAL DERMATOLOGY
(2019)