Reactivity and Selectivity Principles in Native Protein Bioconjugation

Chemoselective and Site‐Selective Lysine‐Directed Lysine Modification Enables Single‐Site Labeling of Native Proteins

(2020) Srinivasa Rao Adusumalli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering

(2020) Madita Wolter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Reagent for Amine‐Directed Conjugation to IgG1 Antibodies

(2020) Anders Märcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

STEFs - Activated Vinylogous Protein-Reactive Electrophiles

(2019) Bente Kring Hansen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Contemporary approaches to site-selective protein modification

(2019) Emily A. Hoyt et al.   Nature Reviews Chemistry

Recent Chemical Approaches for Site‐specific Conjugation of Native Antibodies: Technologies toward Next Generation Antibody‐Drug Conjugates

(2019) Kei Yamada et al.   CHEMBIOCHEM

Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation

(2019) Shang Jia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Latest developments in molecular tracers for fluorescence image-guided cancer surgery

(2019) Sophie Hernot et al.   LANCET ONCOLOGY

Single-site glycine-specific labeling of proteins

(2019) Landa Purushottam et al.   Nature Communications

Site-selective protein modification with polymers for advanced biomedical applications

(2018) Xinyu Liu et al.   BIOMATERIALS

Single-site labeling of lysine in proteins through a metal-free multicomponent approach

(2018) Maheshwerreddy Chilamari et al.   CHEMICAL COMMUNICATIONS

Chemoproteomics and Chemical Probes for Target Discovery

(2018) Gerard Drewes et al.   TRENDS IN BIOTECHNOLOGY

Affinity Enhancement of Protein Ligands by Reversible Covalent Modification of Neighboring Lysine Residues

(2018) Alberto Dal Corso et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads

(2018) Amit Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology

(2018) Srinivasa Rao Adusumalli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A protein functionalization platform based on selective reactions at methionine residues

(2018) Michael T. Taylor et al.   NATURE

Targeting the N terminus for site-selective protein modification

(2017) Christian B Rosen et al.   Nature Chemical Biology

Decarboxylative alkylation for site-selective bioconjugation of native proteins via oxidation potentials

(2017) Steven Bloom et al.   Nature Chemistry

Redox-based reagents for chemoselective methionine bioconjugation

(2017) Shixian Lin et al.   SCIENCE

Clinical chemoproteomics—Opportunities and obstacles

(2017) Lyn H. Jones et al.   Science Translational Medicine

Selective N-terminal functionalization of native peptides and proteins

(2017) Diao Chen et al.   Chemical Science

Orthogonal Cysteine Protection Enables Homogeneous Multi-Drug Antibody-Drug Conjugates

(2016) Matthew R. Levengood et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of Solid-Phase Site-Specific Conjugation and Its Application toward Generation of Dual Labeled Antibody and Fab Drug Conjugates

(2016) Sujiet Puthenveetil et al.   BIOCONJUGATE CHEMISTRY

Chemical Protein Modification through Cysteine

(2016) Smita B. Gunnoo et al.   CHEMBIOCHEM

Simple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapy

(2016) Zhibo Liu et al.   CHEMICAL SOCIETY REVIEWS

Current Status: Site-Specific Antibody Drug Conjugates

(2016) Dominik Schumacher et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Transition Metal-Free Tryptophan-Selective Bioconjugation of Proteins

(2016) Yohei Seki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in the construction of antibody–drug conjugates

(2016) Vijay Chudasama et al.   Nature Chemistry

Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins

(2016) Somasekhar Bondalapati et al.   Nature Chemistry

One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody–drug conjugates

(2016) Feng Tang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bioconjugation – using selective chemistry to enhance the properties of proteins and peptides as therapeutics and carriers

(2016) Smita B. Gunnoo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Emerging Strategies for Developing Next-Generation Protein Therapeutics for Cancer Treatment

(2016) James R. Kintzing et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fast and selective labeling of N-terminal cysteines at neutral pH via thiazolidino boronate formation

(2016) Anupam Bandyopadhyay et al.   Chemical Science

Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

(2016) Barbara Bernardim et al.   Nature Communications

A phthalimidation protocol that follows protein defined parameters

(2015) Rohith Singudas et al.   CHEMICAL COMMUNICATIONS

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

(2015) Oleksandr Koniev et al.   CHEMICAL SOCIETY REVIEWS

Covalent protein modification: the current landscape of residue-specific electrophiles

(2015) D Alexander Shannon et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Comprehensive characterization of the Published Kinase Inhibitor Set

(2015) Jonathan M Elkins et al.   NATURE BIOTECHNOLOGY

One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes

(2015) James I MacDonald et al.   Nature Chemical Biology

Site-selective protein-modification chemistry for basic biology and drug development

(2015) Nikolaus Krall et al.   Nature Chemistry

Selective chemical protein modification

(2014) Christopher D. Spicer et al.   Nature Communications

Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

(2013) Pavel Strop et al.   CHEMISTRY & BIOLOGY

Methods for site-specific drug conjugation to antibodies

(2013) Christopher R Behrens et al.   mAbs

Site-specific chemical modification of antibody fragments using traceless cleavable linkers

(2013) Gonçalo J L Bernardes et al.   Nature Protocols

Site-Selective Lysine Modification of Native Proteins and Peptides via Kinetically Controlled Labeling

(2012) Xi Chen et al.   BIOCONJUGATE CHEMISTRY

How Chemoproteomics Can Enable Drug Discovery and Development

(2012) Raymond E. Moellering et al.   CHEMISTRY & BIOLOGY

Site-Specific Traceless Coupling of Potent Cytotoxic Drugs to Recombinant Antibodies for Pharmacodelivery

(2012) Giulio Casi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

(2012) J. Y. Axup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A “Tag-and-Modify” Approach to Site-Selective Protein Modification

(2011) Justin M. Chalker et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bromopyridazinedione-mediated protein and peptide bioconjugation

(2011) Vijay Chudasama et al.   CHEMICAL COMMUNICATIONS

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins

(2009) Hongjun Ren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemoselective Tryptophan Labeling with Rhodium Carbenoids at Mild pH

(2009) John M. Antos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-directed tosyl chemistry for protein labeling in vivo

(2009) Shinya Tsukiji et al.   Nature Chemical Biology

Affinity‐Labeling‐Based Introduction of a Reactive Handle for Natural Protein Modification

(2008) Haruto Wakabayashi et al.   Chemistry-An Asian Journal

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY

Disparate proteome reactivity profiles of carbon electrophiles

(2008) Eranthie Weerapana et al.   Nature Chemical Biology