Clinical chemoproteomics—Opportunities and obstacles

Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes

(2017) Qian Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding the chemically-reactive proteome

(2016) Lyn H. Jones   Molecular BioSystems

Large-scale implementation of sequential protein and peptide immunoaffinity enrichment LC/nanoLC–MS/MS for human β-nerve growth factor

(2016) Gary A Schultz et al.   Bioanalysis

RepExplore: addressing technical replicate variance in proteomics and metabolomics data analysis

(2015) Enrico Glaab et al.   BIOINFORMATICS

Cell permeable affinity- and activity-based probes

(2015) Lyn H Jones   Future Medicinal Chemistry

Preclinical target validation using patient-derived cells

(2015) Aled M. Edwards et al.   NATURE REVIEWS DRUG DISCOVERY

Single-cell analysis tools for drug discovery and development

(2015) James R. Heath et al.   NATURE REVIEWS DRUG DISCOVERY

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

A small-molecule antivirulence agent for treating Clostridium difficile infection

(2015) Kristina Oresic Bender et al.   Science Translational Medicine

Activity-based probes as molecular tools for biomarker discovery

(2015) L. A. R. Carvalho et al.   MedChemComm

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

(2014) Bryan R Lanning et al.   Nature Chemical Biology

Quantitative shotgun proteomics: considerations for a high-quality workflow in immunology

(2014) Felix Meissner et al.   NATURE IMMUNOLOGY

Demystifying Disease, Democratizing Health Care

(2014) L. Hood et al.   Science Translational Medicine

Determining target engagement in living systems

(2013) Gabriel M Simon et al.   Nature Chemical Biology

Target validation using chemical probes

(2013) Mark E Bunnage et al.   Nature Chemical Biology

Multiplexed MS/MS for improved data-independent acquisition

(2013) Jarrett D Egertson et al.   NATURE METHODS

Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

(2013) John C. Byrd et al.   NEW ENGLAND JOURNAL OF MEDICINE

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Is phosphoproteomics ready for clinical research?

(2012) Anton B. Iliuk et al.   CLINICA CHIMICA ACTA

Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes

(2012) Alexander Adibekian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Impact of pre-analytical factors on the proteomic analysis of formalin-fixed paraffin-embedded tissue

(2012) Seonaid M. Thompson et al.   Proteomics Clinical Applications

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

(2011) Matthew P. Patricelli et al.   CHEMISTRY & BIOLOGY

Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events

(2011) S. Arastu-Kapur et al.   CLINICAL CANCER RESEARCH

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

(2011) Paul Morgan et al.   DRUG DISCOVERY TODAY

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

(2011) K. Ahn et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry

Immunofluorometric activity-based probe analysis of active KLK6 in biological fluids

(2008) Katerina Oikonomopoulou et al.   BIOLOGICAL CHEMISTRY