Affinity Enhancement of Protein Ligands by Reversible Covalent Modification of Neighboring Lysine Residues

DNA-Encoded Chemical Libraries: A Selection System Based on Endowing Organic Compounds with Amplifiable Information

(2018) Dario Neri et al.   Annual Review of Biochemistry

Kinase inhibitors: the road ahead

(2018) Fleur M. Ferguson et al.   NATURE REVIEWS DRUG DISCOVERY

Spatial Screening of Hemagglutinin on Influenza A Virus Particles: Sialyl-LacNAc Displays on DNA and PEG Scaffolds Reveal the Requirements for Bivalency Enhanced Interactions with Weak Monovalent Binders

(2017) Victor Bandlow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Covalent Inhibitors for Drug Design

(2016) Thomas A. Baillie   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting biomolecules with reversible covalent chemistry

(2016) Anupam Bandyopadhyay et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain

(2016) Gizem Akçay et al.   Nature Chemical Biology

DNA-encoded chemistry: enabling the deeper sampling of chemical space

(2016) Robert A. Goodnow et al.   NATURE REVIEWS DRUG DISCOVERY

Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties

(2016) C. Zambaldo et al.   MedChemComm

Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules

(2015) Jean-Pierre Daguer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA display of glycoconjugates to emulate oligomeric interactions of glycans

(2015) Alexandre Novoa et al.   Beilstein Journal of Organic Chemistry

Novel selection methods for DNA-encoded chemical libraries

(2015) Alix I Chan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes

(2015) James I MacDonald et al.   Nature Chemical Biology

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation

(2015) Moreno Wichert et al.   Nature Chemistry

Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII

(2013) Shyamasri Biswas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library

(2012) Markus Leimbacher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iminoboronates: A New Strategy for Reversible Protein Modification

(2012) Pedro M. S. D. Cal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Sensitized Detection of Inhibitory Fragments and Iterative Development of Non-Peptidic Protease Inhibitors by Dynamic Ligation Screening

(2008) Marco Florian Schmidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Portable Albumin Binder from a DNA-Encoded Chemical Library

(2008) Christoph E. Dumelin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION