Antidepressant effect of catalpol on corticosterone-induced depressive-like behavior involves the inhibition of HPA axis hyperactivity, central inflammation and oxidative damage probably via dual regulation of NF-κB and Nrf2

Antidepressant-like effects of penta-acetyl geniposide in chronic unpredictable mild stress-induced depression rat model: Involvement of inhibiting neuroinflammation in prefrontal cortex and regulating hypothalamic-pituitaryadrenal axis

(2020) Li Cai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Saikosaponin d downregulates microRNA-155 and upregulates FGF2 to improve depression-like behaviors in rats induced by unpredictable chronic mild stress by negatively regulating NF-κB

(2020) Bin Chao et al.   BRAIN RESEARCH BULLETIN

Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat

(2020) Hetao Bian et al.   Journal of Neuroinflammation

The neuroprotective effect of Riparin IV on oxidative stress and neuroinflammation related to chronic stress-induced cognitive impairment

(2020) Raquell de Castro Chaves et al.   HORMONES AND BEHAVIOR

Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling

(2020) Tahir Ali et al.   Frontiers in Molecular Neuroscience

Antidepressant and Anti-Neuroinflammatory Effects of Bangpungtongsung-San

(2020) Bo-Kyung Park et al.   Frontiers in Pharmacology

Multiple cellular targets involved in the antidepressant-like effect of glutathione

(2020) Alcir Luiz Dafre et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling

(2020) Anderson Camargo et al.   NEUROCHEMISTRY INTERNATIONAL

Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats

(2020) Dehua Liao et al.   Oxidative Medicine and Cellular Longevity

Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice

(2019) E.H. Taniguti et al.   BRAIN RESEARCH BULLETIN

Ro41-5253, a selective antagonist of retinoic acid receptor α, ameliorates chronic unpredictable mild stress-induced depressive-like behaviors in rats: Involvement of regulating HPA axis and improving hippocampal neuronal deficits

(2019) Qi Ke et al.   BRAIN RESEARCH BULLETIN

Depression comorbid with hyperalgesia: different roles of neuroinflammation induced by chronic stress and hypercortisolism

(2019) Jingjie Zhao et al.   JOURNAL OF AFFECTIVE DISORDERS

The Long-Term Effects of Ethanol and Corticosterone on the Mood-Related Behaviours and the Balance Between Mature BDNF and proBDNF in Mice

(2019) L. Y. Lin et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice

(2019) Raquell de Castro Chaves et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities

(2019) Ana Lúcia Bertarello Zeni et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Avicularin Relieves Depressive-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice

(2019) Zhongfei Shen et al.   MEDICAL SCIENCE MONITOR

Persistent depressive symptoms, HPA-axis hyperactivity, and inflammation: the role of cognitive-affective and somatic symptoms

(2019) Eleonora Iob et al.   MOLECULAR PSYCHIATRY

Catalpol in Diabetes and its Complications: A Review of Pharmacology, Pharmacokinetics, and Safety

(2019) Ying Bai et al.   MOLECULES

Revealing Antidepressant Mechanisms of Baicalin in Hypothalamus Through Systems Approaches in Corticosterone- Induced Depressed Mice

(2019) Kuo Zhang et al.   Frontiers in Neuroscience

Antidepressant-like effects of the Guanxin Danshen formula via mediation of the CaMK II-CREB-BDNF signalling pathway in chronic unpredictable mild stress-induced depressive rats

(2019) Weijie Xie et al.   Annals of Translational Medicine

Adipose-derived mesenchymal stem cells protect against CMS-induced depression-like behaviors in mice via regulating the Nrf2/HO-1 and TLR4/NF-κB signaling pathways

(2019) Xiao Huang et al.   ACTA PHARMACOLOGICA SINICA

Nicotinamide mononucleotide ameliorates the depression-like behaviors and is associated with attenuating the disruption of mitochondrial bioenergetics in depressed mice

(2019) Xiaoxian Xie et al.   JOURNAL OF AFFECTIVE DISORDERS

Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine

(2019) Satoshi Deyama et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice

(2019) Qingfeng Xiao et al.   PHYSIOLOGY & BEHAVIOR

PDTC Alleviates Depressive Symptoms and Colon Tissue Injury via Inhibiting NO Overproduction in CUMS Rats

(2019) Lejin Yang et al.   Frontiers in Neuroscience

Multiple Biological Effects of an Iridoid Glucoside, Catalpol, and Its Underlying Molecular Mechanisms

(2019) Subrat Kumar Bhattamisra et al.   Biomolecules

Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice

(2018) Athira KV et al.   BEHAVIOURAL BRAIN RESEARCH

Apocynum venetum leaf extract reverses depressive-like behaviors in chronically stressed rats by inhibiting oxidative stress and apoptosis

(2018) Xiangting Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Gypenosides reverses depressive behavior via inhibiting hippocampal neuroinflammation

(2018) Shu-Qi Dong et al.   BIOMEDICINE & PHARMACOTHERAPY

Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity

(2018) Han Weina et al.   BRAIN RESEARCH

Cholecalciferol counteracts depressive-like behavior and oxidative stress induced by repeated corticosterone treatment in mice

(2018) Anderson Camargo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Riparin II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms

(2018) Iardja Stéfane Lopes et al.   NEUROCHEMISTRY INTERNATIONAL

Drugs which influence serotonin transporter and serotonergic receptors: Pharmacological and clinical properties in the treatment of depression

(2018) Przemysław Paweł Taciak et al.   Pharmacological Reports

Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway

(2018) Jiting Yan et al.   PHARMACOLOGICAL RESEARCH

Peripheral markers of inflammation, oxidative & nitrosative stress pathways and memory functions as a new target of pharmacotherapy in depression

(2018) Piotr Gałecki   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression

(2018) Piotr Czarny et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Chronic stress, hair cortisol and depression: A prospective and longitudinal study of medical internship

(2018) Stefanie E. Mayer et al.   PSYCHONEUROENDOCRINOLOGY

Perfluorooctane sulfonate (PFOS) can alter the hypothalamic–pituitary–adrenal (HPA) axis activity by modifying CRF1 and glucocorticoid receptors

(2018) R. Salgado-Freiría et al.   TOXICOLOGY LETTERS

Crocin, a natural product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway

(2018) Lang Zhang et al.   BRAIN RESEARCH BULLETIN

Direct and indirect evidences of BDNF and NGF as key modulators in depression: Role of antidepressants treatment

(2018) Amal Chandra Mondal et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions

(2018) Ting-Ting Dai et al.   NEUROSCIENCE

The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology

(2018) Emily L. Belleau et al.   BIOLOGICAL PSYCHIATRY

Agarwood Essential Oil Ameliorates Restrain Stress-Induced Anxiety and Depression by Inhibiting HPA Axis Hyperactivity

(2018) Shuai Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Excessive corticosterone induces excitotoxicity of hippocampal neurons and sensitivity of potassium channels via insulin-signaling pathway

(2018) Qingqing Xia et al.   METABOLIC BRAIN DISEASE

Ninjinyoeito Improves Behavioral Abnormalities and Hippocampal Neurogenesis in the Corticosterone Model of Depression

(2018) Kenta Murata et al.   Frontiers in Pharmacology

Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation

(2017) Carmine M. Pariante   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress

(2017) Ya-Min Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Suppressive Effect of Ginsenoside Rg3 against Lipopolysaccharide-Induced Depression-Like Behavior and Neuroinflammation in Mice

(2017) An Kang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Biological and behavioural antidepressant treatment responses with the selective serotonin reuptake inhibitor fluoxetine can be determined by the environment

(2017) A W Licinio et al.   MOLECULAR PSYCHIATRY

Oxytocin in corticosterone-induced chronic stress model: Focus on adrenal gland function

(2017) Dušanka Stanić et al.   PSYCHONEUROENDOCRINOLOGY

Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis

(2017) Hong-Yan Li et al.   PSYCHOPHARMACOLOGY

The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex

(2017) Wei Liu et al.   NEURAL PLASTICITY

IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids

(2017) E. Martín-Montañez et al.   Redox Biology

Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex

(2016) Song liu et al.   BEHAVIOURAL BRAIN RESEARCH

Apigenin reverses depression-like behavior induced by chronic corticosterone treatment in mice

(2016) Lianjin Weng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antidepressant-Like Effects of Fractions Prepared from Danzhi-Xiaoyao-San Decoction in Rats with Chronic Unpredictable Mild Stress: Effects on Hypothalamic-Pituitary-Adrenal Axis, Arginine Vasopressin, and Neurotransmitters

(2016) Li-Li Wu et al.   Evidence-based Complementary and Alternative Medicine

Antidepressant-like effects of Xiaochaihutang in a neuroendocrine mouse model of anxiety/depression

(2016) Kuo Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic Abnormalities Induced by Chronic Corticosterone Injection

(2016) Yu-Cheng Li et al.   MOLECULES

Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice

(2016) Thomas Demuyser et al.   NEUROSCIENCE LETTERS

Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway

(2016) Tingxu Yan et al.   PSYCHIATRY RESEARCH

Activation of the HPA axis and depression of feeding behavior induced by restraint stress are separately regulated by PACAPergic neurotransmission in the mouse

(2016) Sunny Zhihong Jiang et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Effect of chronic corticosterone application on depression-like behavior in C57BL/6N and C57BL/6J mice

(2015) M. Sturm et al.   GENES BRAIN AND BEHAVIOR

Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice

(2015) Andiara E. Freitas et al.   MOLECULAR NEUROBIOLOGY

Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway

(2015) Francis L. Pazini et al.   MOLECULAR NEUROBIOLOGY

The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders

(2015) G.Z. Réus et al.   NEUROSCIENCE

Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression

(2015) Indira Mendez-David et al.   NEUROSCIENCE LETTERS

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

(2015) Jun-Ming Wang et al.   PHYSIOLOGY & BEHAVIOR

Is depression associated with increased oxidative stress? A systematic review and meta-analysis

(2015) Catherine N. Black et al.   PSYCHONEUROENDOCRINOLOGY

Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice

(2015) Syed Hamid Ali et al.   STEROIDS

Effect of a novel 5-HT 3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice

(2015) Deepali Gupta et al.   STEROIDS

Neural stem cells respond to stress hormones: distinguishing beneficial from detrimental stress

(2015) Yassemi Koutmani et al.   Frontiers in Physiology

Involvement of the central monoaminergic system in the antidepressant-like effect of catalpol in mice

(2014) Junming Wang et al.   BioScience Trends

Antidepressant-like responses in the forced swimming test elicited by glutathione and redox modulation

(2013) Juliana M. Rosa et al.   BEHAVIOURAL BRAIN RESEARCH

Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF

(2013) Dong Wan et al.   Evidence-based Complementary and Alternative Medicine

Catalpol decreases peroxynitrite formation and consequently exerts cardioprotective effects against ischemia/reperfusion insult

(2013) Chaolian Huang et al.   PHARMACEUTICAL BIOLOGY

Etazolate, a phosphodiesterase 4 inhibitor reverses chronic unpredictable mild stress-induced depression-like behavior and brain oxidative damage

(2013) Ankur Jindal et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Depression and Oxidative Stress

(2013) Priya Palta et al.   PSYCHOSOMATIC MEDICINE

Depression and Inflammation: An Intricate Relationship

(2011) Robert Dantzer   BIOLOGICAL PSYCHIATRY

Pharmacological characterization of repeated corticosterone injection-induced depression model in rats

(2010) Michihiko Iijima et al.   BRAIN RESEARCH

Major Depressive Disorder and Hypothalamic-Pituitary-Adrenal Axis Activity

(2009) Sophie A. Vreeburg et al.   ARCHIVES OF GENERAL PSYCHIATRY

A mouse model of depression induced by repeated corticosterone injections

(2008) Yunan Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rehmannia glutinosa: Review of botany, chemistry and pharmacology

(2008) Ru-Xue Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

The link between childhood trauma and depression: Insights from HPA axis studies in humans

(2008) Christine Heim et al.   PSYCHONEUROENDOCRINOLOGY

Modulation ofin vivooxidative status by exogenous corticosterone and restraint stress in rats

(2008) Ayesha Zafir et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS