Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway

The modulation of NMDA receptors and l-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test

(2015) Mauricio P. Cunha et al.   AMINO ACIDS

Ketamine as a promising prototype for a new generation of rapid-acting antidepressants

(2015) Chadi G. Abdallah et al.   Annals of the New York Academy of Sciences

Effect of subanaesthetic ketamine on plasma and saliva cortisol secretion

(2015) N. Khalili-Mahani et al.   BRITISH JOURNAL OF ANAESTHESIA

Involvement of PI3K/Akt Signaling Pathway and Its Downstream Intracellular Targets in the Antidepressant-Like Effect of Creatine

(2015) Mauricio P. Cunha et al.   MOLECULAR NEUROBIOLOGY

Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors

(2015) Alexis S Hill et al.   NEUROPSYCHOPHARMACOLOGY

Both Creatine and Its Product Phosphocreatine Reduce Oxidative Stress and Afford Neuroprotection in an In Vitro Parkinson’s Model

(2014) Mauricio Peña Cunha et al.   ASN Neuro

Piperine reverses the effects of corticosterone on behavior and hippocampal BDNF expression in mice

(2014) Qing-Qiu Mao et al.   NEUROCHEMISTRY INTERNATIONAL

Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

(2014) Peng Zhong et al.   NEUROPSYCHOPHARMACOLOGY

Effects ofl-arginine and creatine administration on spatial memory in rats subjected to a chronic variable stress model

(2014) Fabio Seidel dos Santos et al.   PHARMACEUTICAL BIOLOGY

Folic acid prevents depressive-like behavior induced by chronic corticosterone treatment in mice

(2014) Priscila B. Rosa et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Evidence for the involvement of 5-HT1A receptor in the acute antidepressant-like effect of creatine in mice

(2013) Mauricio P. Cunha et al.   BRAIN RESEARCH BULLETIN

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex

(2013) W. Zhou et al.   EUROPEAN PSYCHIATRY

A pilot dose-finding clinical trial of creatine monohydrate augmentation to SSRIs/SNRIs/NASA antidepressant treatment in major depression

(2013) Boris Nemets et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Protective effect of creatine against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells: Involvement of intracellular signaling pathways

(2013) M.P. Cunha et al.   NEUROSCIENCE

The activation of α1-adrenoceptors is implicated in the antidepressant-like effect of creatine in the tail suspension test

(2013) Mauricio P. Cunha et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Randomized, Double-Blind Placebo-Controlled Trial of Oral Creatine Monohydrate Augmentation for Enhanced Response to a Selective Serotonin Reuptake Inhibitor in Women With Major Depressive Disorder

(2012) In Kyoon Lyoo et al.   AMERICAN JOURNAL OF PSYCHIATRY

Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide–cGMP and PI3K/mTOR pathways

(2012) Luis E.B. Bettio et al.   BEHAVIOURAL BRAIN RESEARCH

Acute atorvastatin treatment exerts antidepressant-like effect in mice via the l-arginine–nitric oxide–cyclic guanosine monophosphate pathway and increases BDNF levels

(2012) Fabiana K. Ludka et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Antidepressant-like effect of creatine in mice involves dopaminergic activation

(2012) Mauricio P Cunha et al.   JOURNAL OF PSYCHOPHARMACOLOGY

In Vivo Manganese Exposure Modulates Erk, Akt and Darpp-32 in the Striatum of Developing Rats, and Impairs Their Motor Function

(2012) Fabiano M. Cordova et al.   PLoS One

Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress

(2012) Agata Chandran et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review of Atypical depression in relation to the course of depression and changes in HPA axis organization

(2012) Veronica O’Keane et al.   PSYCHONEUROENDOCRINOLOGY

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Intravenous Ketamine for Treatment-Resistant Major Depressive Disorder

(2011) Jordan R Covvey et al.   ANNALS OF PHARMACOTHERAPY

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

Investigational NMDA receptor modulators for depression

(2011) Bernadeta Szewczyk et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

mTOR activation is required for the antidepressant effects of mGluR2/3 blockade

(2011) Jason M. Dwyer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety

(2011) Quentin Rainer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: A 31-phosphorus magnetic resonance spectroscopy study

(2011) Douglas G. Kondo et al.   JOURNAL OF AFFECTIVE DISORDERS

Involvement of PI3K, GSK-3β and PPARγ in the antidepressant-like effect of folic acid in the forced swimming test in mice

(2011) Josiane Budni et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Signaling pathways underlying the rapid antidepressant actions of ketamine

(2011) Ronald S. Duman et al.   NEUROPHARMACOLOGY

Depressive-like behavior induced by tumor necrosis factor-α in mice

(2011) Manuella P. Kaster et al.   NEUROPHARMACOLOGY

Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats

(2011) Zhen Huang et al.   NEUROSCIENCE LETTERS

Long-Term Continuous Corticosterone Treatment Decreases VEGF Receptor-2 Expression in Frontal Cortex

(2011) Kristy R. Howell et al.   PLoS One

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Brain-derived neurotrophic factor and suicide pathogenesis

(2010) Yogesh Dwivedi   ANNALS OF MEDICINE

Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain

(2010) Qing-Qiu Mao et al.   BEHAVIOURAL BRAIN RESEARCH

Effect of antidepressants on brain-derived neurotrophic factor (BDNF) release from platelets in the rats

(2010) Kimihiko Watanabe et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Behavioral and neurobiological consequences of prolonged glucocorticoid exposure in rats: Relevance to depression

(2010) Erin Y. Sterner et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression

(2010) Hiroshi Kunugi et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

A Glutamate Pathway to Faster-Acting Antidepressants?

(2010) J. F. Cryan et al.   SCIENCE

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

The varying effects of short-term and long-term corticosterone injections on depression-like behavior in mice

(2009) Yunan Zhao et al.   BRAIN RESEARCH

Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons

(2009) Deborah N. Alfarez et al.   HIPPOCAMPUS

Morphological reorganization after repeated corticosterone administration in the hippocampus, nucleus accumbens and amygdala in the rat

(2009) Julio César Morales-Medina et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

Chronic Creatine Supplementation Alters Depression-like Behavior in Rodents in a Sex-Dependent Manner

(2009) Patricia J Allen et al.   NEUROPSYCHOPHARMACOLOGY

Accelerating response to antidepressant treatment in depression: A review and clinical suggestions

(2009) Shinichiro Nakajima et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Acute Hippocampal Brain-Derived Neurotrophic Factor Restores Motivational and Forced Swim Performance After Corticosterone

(2008) Shannon L. Gourley et al.   BIOLOGICAL PSYCHIATRY

A mouse model of depression induced by repeated corticosterone injections

(2008) Yunan Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression

(2008) Yukio Ago et al.   NEUROPHARMACOLOGY

Effects of fluoxetine and venlafaxine on serum brain derived neurotrophic factor levels in depressed patients

(2008) Ayse Devrim Başterzi et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

(2008) Anteneh M. Feyissa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY