Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat

FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway

(2020) Xue Wang et al.   Frontiers in Pharmacology

A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

(2019) Ram Kuwar et al.   Journal of Neuroinflammation

Extract From Plectranthus amboinicus Inhibit Maturation and Release of Interleukin 1β Through Inhibition of NF-κB Nuclear Translocation and NLRP3 Inflammasome Activation

(2019) Wohn-Jenn Leu et al.   Frontiers in Pharmacology

DNA methylation of the Tacr2 gene in a CUMS model of depression

(2019) Dan Xiang et al.   BEHAVIOURAL BRAIN RESEARCH

Markers of central inflammation in major depressive disorder: A systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue

(2019) Daniela Enache et al.   BRAIN BEHAVIOR AND IMMUNITY

Houttuynia cordata Thunb. and its bioactive compound 2-undecanone significantly suppress benzo(a)pyrene-induced lung tumorigenesis by activating the Nrf2-HO-1/NQO-1 signaling pathway

(2019) Yanmei Lou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

(2019) Burak I. Arioz et al.   Frontiers in Immunology

Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β

(2019) Aaron Talty et al.   Cell Death & Disease

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

(2019) Thomas Scambler et al.   eLife

The formative role of microglia in stress-induced synaptic deficits and associated behavioral consequences

(2019) J.L. Bollinger et al.   NEUROSCIENCE LETTERS

Inflammation and depressive phenotypes: evidence from medical records from over 12 000 patients and brain morphology

(2019) Maria Ironside et al.   PSYCHOLOGICAL MEDICINE

α-Lipoic Acid Inhibits IL-8 Expression by Activating Nrf2 Signaling in Helicobacter pylori-infected Gastric Epithelial Cells

(2019) Seoyeon Kyung et al.   Nutrients

Intranasal MMI-0100 Attenuates Aβ1−42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway

(2019) JinHong Jiang et al.   Frontiers in Immunology

Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats

(2019) Saleem H. Aladaileh et al.   Antioxidants

High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes

(2019) Huma Rizwan et al.   LIFE SCIENCES

The dietary triterpenoid 18α–Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway

(2019) Maria Lefaki et al.   Redox Biology

Induction of Antioxidant Protein HO-1 Through Nrf2-ARE Signaling Due to Pteryxin in Peucedanum Japonicum Thunb in RAW264.7 Macrophage Cells

(2019) Junsei Taira et al.   Antioxidants

Depression and sterile inflammation: Essential role of danger associated molecular patterns

(2018) Tina C. Franklin et al.   BRAIN BEHAVIOR AND IMMUNITY

Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes

(2018) Yochai Birnbaum et al.   CARDIOVASCULAR DRUGS AND THERAPY

Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats

(2018) Ya-Lin Wang et al.   Journal of Neuroinflammation

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Sex-dependent impact of different degrees of maternal separation experience on OFT behavioral performances after adult chronic unpredictable mild stress exposure in rats

(2018) Yanyan Wei et al.   PHYSIOLOGY & BEHAVIOR

Neuroimmunomodulation in Major Depressive Disorder: Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gamma

(2018) Antonio Inserra et al.   MOLECULAR NEUROBIOLOGY

The AIM2 inflammasome: Sensor of pathogens and cellular perturbations

(2017) Jérôme Lugrin et al.   IMMUNOLOGICAL REVIEWS

The NLRC4 Inflammasome

(2017) Joseph A. Duncan et al.   IMMUNOLOGICAL REVIEWS

Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome

(2017) Pei Jiang et al.   Journal of Neuroinflammation

Estradiol postconditioning relieves ischemia/reperfusion injury in axial skin flaps of rats, inhibits apoptosis and alters the MKP-1/ERK pathway

(2017) Qianheng Jin et al.   Molecular Medicine Reports

Time courses of post-injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain injury

(2017) Rachel L. Hill et al.   NEUROCHEMISTRY INTERNATIONAL

Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat

(2017) Keren Zhou et al.   STROKE

Central administration of tert -butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats

(2017) Juan Bai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice

(2017) Chunyang Zhao et al.   Acta Pharmaceutica Sinica B

Neuroprotection of Brain Cells by Lipoic Acid Treatment after Cellular Stress

(2016) Sara Paradells-Navarro et al.   ACS Chemical Neuroscience

Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses

(2016) Jerome Sarris et al.   AMERICAN JOURNAL OF PSYCHIATRY

Differential changes in Neuregulin-1 signaling in major brain regions in a lipopolysaccharide-induced neuroinflammation mouse model

(2016) ZHAI YANG et al.   Molecular Medicine Reports

Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells

(2016) Grace Y. Sun et al.   NEUROMOLECULAR MEDICINE

Spirulina diet to lactating mothers protects the antioxidant system and reduces inflammation in post-natal brain after systemic inflammation

(2016) Jaspal Patil et al.   NUTRITIONAL NEUROSCIENCE

Differential effects of a short-term high-fat diet in an animal model of depression in rats treated with the 5-HT3 receptor antagonist, ondansetron, the 5-HT3 receptor agonist, 2-methyl-5-HT, and the SSRI, fluoxetine

(2016) Isabel C. Sumaya et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Lipoic acid protects dopaminergic neurons in LPS-induced Parkinson’s disease model

(2015) Yan-Hua Li et al.   METABOLIC BRAIN DISEASE

Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke

(2015) Ming-Hsiu Wu et al.   MOLECULAR NEUROBIOLOGY

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

(2015) Dora Brites et al.   Frontiers in Cellular Neuroscience

Lipoic acid – biological activity and therapeutic potential

(2014) Anna Gorąca et al.   Pharmacological Reports

α-lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet

(2013) YULIAN MIAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity

(2009) Alex G. McKee et al.   JOURNAL OF NEUROCHEMISTRY

The Nrf2/ARE Pathway as a Potential Therapeutic Target in Neurodegenerative Disease

(2008) Marcus J. Calkins et al.   ANTIOXIDANTS & REDOX SIGNALING