Article
Neurosciences
Xiaoli Wu, Jingwen Gu, Zhicong Zou, Meng Yu, Chen Zhang, Qinghui Xiao, Xin Chen, Chuwen Li
Summary: Isofraxidin has antidepressant-like effects in CUMS-induced mice, accompanied by inhibition of hyperactivity of the HPA axis and NF-kappa B /NLRP3 inflammasomes pathways.
Article
Chemistry, Medicinal
Tong Chen, Shengnan Liu, Menglin Zheng, Yixuan Li, Ling He
Summary: The study demonstrated that geniposide could improve depressive symptoms in CUMS-induced mice by regulating inflammatory cytokines and oxidative stress. Additionally, geniposide affected various protein kinases and signaling pathways, exerting an antidepressant effect.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xinfei Ma, Zhenhua Zhu, Sheng Guo, Jinao Duan
Summary: The purpose of this study was to evaluate the antidepressant effect of deoxyschizandrin (DEO) in chronic unpredictable mild stress (CUMS)-induced mice. DEO treatment alleviated anhedonia and reduced immobile duration in behavior tests. DEO effectively attenuated the CUMS-induced alterations in hippocampal proteins and inflammatory cytokine levels, as well as increased dendritic spine density.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Article
Engineering, Biomedical
Xin Wang, Baokun Zhang, Zhiheng Chen, Qiang Shi, Erzhu Yang, Jianguang Xu, Xiaofeng Lian
Summary: Following spinal cord injury, the disruption of the blood-spinal cord barrier (BSCB) and hemorrhage lead to progressive secondary injuries. Bazedoxifene, a third-generation estrogen receptor modulator, has been found to inhibit inflammation and blood-brain barrier disruption caused by traumatic brain injury. In this study, a new biomaterial carrier was developed to deliver Bazedoxifene to the site of spinal cord injury and effectively attenuate BSCB disruption through the NF-KB pathway, providing potential therapeutic benefits for spinal cord repair.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Zi-Rong Li, Yuan-Shan Han, Zhuo Liu, Hong-Qing Zhao, Jian Liu, Hui Yang, Yu-Hong Wang
Summary: This study explored the pathogenesis of diabetes combined with depression and the effect of dexamethasone on hippocampal neuroinflammation in diabetic rats with chronic unpredictable mild stress. The findings indicate that diabetes and depression can lead to hippocampal inflammatory damage, which can be reversed by dexamethasone through inhibiting inflammatory reactions, thus exerting an antidepressant effect.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Bin Lv, Naiting Shen, Zhangrong Cheng, Yuhang Chen, Hua Ding, Jishan Yuan, Kangchen Zhao, Yukun Zhang
Summary: The TLR4-NF-κB signaling pathway plays an important role in the recovery after spinal cord injury (SCI). It can alleviate inflammatory responses, modulate autophagy, apoptosis and ferroptosis, and enhance the anti-oxidative effect. Novel biomaterials as scaffolds and carriers have been designed to regulate TLR4-NF-κB and inhibit the progression of SCI.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Jingyi Mi, Yang Yang, Hao Yao, Zhirong Huan, Ce Xu, Zhiheng Ren, Wenfu Li, Ying Tang, Rao Fu, Xin Ge
Summary: The study showed that silencing HSPA8 can alleviate spinal cord damage caused by SCII by inhibiting astrocyte activation and NF-κB, NLRP3 inflammasome activation, leading to reduced neuroinflammation and protection of neurons.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biotechnology & Applied Microbiology
Dexiang Ban, Peng Yu, Zhenyang Xiang, Yang Liu
Summary: The TWEAK/NF-kappa B pathway plays an important role in the non-canonical signaling pathways. Inhibiting this pathway can restrain the excessive growth of astrocytes and promote the growth of neurons. These findings have important implications for the treatment of spinal cord injury.
Review
Neurosciences
Yi Ding, Qin Chen
Summary: Spinal cord injury (SCI) is a traumatic central nervous system injury that can lead to severe nerve damage. Inflammatory response plays a crucial role in secondary injury. Prolonged inflammation can worsen the injured site's microenvironment, resulting in neural function deterioration. Understanding the NF-kappa B pathway and its regulation of inflammation after SCI is crucial for developing new therapies. Inhibiting the NF-kappa B pathway improves the inflammatory microenvironment and enhances neural function recovery, making it a potential therapeutic target for SCI.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Wenqing Li, Fubo Han, Kaifan Tang, Chengjie Ding, Fen Xiong, Yina Xiao, Chen Li, Qian Liang, Kwang Youl Lee, Ik-Soo Lee, Hongchang Gao
Summary: Demethylzeylasteral exhibits promising potential as a treatment for colon cancer by inhibiting S100A11 expression and directly interacting with it to attenuate cell proliferation. NF-kappa B acts as an upstream transcription factor regulating S100A11 expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Yuying Li, Huiping Qiu, Shuihong Yao, Qunfeng Li, Yuemin Ding, Yanhui Cao, Xuming Chen, Xiaoping Zhu
Summary: The study shows that Gen can promote the recovery of SCI rats, reduce inflammation, and enhance motor function and axon regeneration by inhibiting the IKKs/NF-κB signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Wenbin Zhang, Mengxian Jia, Jiashu Lian, Sheng Lu, Jian Zhou, Ziwei Fan, Zhoule Zhu, Yaozhi He, Changgang Huang, Mingyu Zhu, Jian Wang, Ying Wang, Zhihui Huang, Honglin Teng
Summary: TBK1 plays an important role in the pathogenesis of spinal cord injury (SCI) by mediating innate immune pathways in astrocytes through YAP signaling. Inhibition of TBK1 activity alleviates neuroinflammation, reduces motor neuron loss, and improves functional recovery.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Food Science & Technology
Zhipeng Li, Qingchen Wang, Zhonghong Zhang, Yaping Guo, Mingna Sun, Li Li, Wenbin He
Summary: This study found that chrysin, a natural flavonoid compound, can alleviate neuroinflammation and depressive-like behaviors induced by chronic stress by inhibiting the activation of Fyn and NF-κB pathway.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Hui Li, Bingqiang He, Xingyuan Zhang, Huifei Hao, Ting Yang, Chunshuai Sun, Honghua Song, Yingjie Wang, Yue Zhou, Zhenjie Zhu, Yuming Hu, Yongjun Wang
Summary: D-DT is a novel proinflammatory mediator of reactive astrocytes after spinal cord injury, which can activate multiple signal pathways of astrocytes and induce the production of inflammatory cytokines through interaction with CD74 receptor. Inhibition of D-DT can attenuate NF-kappa B activation, reduce the levels of inflammatory cytokines, and improve locomotor function recovery.
CELL AND BIOSCIENCE
(2022)
Article
Behavioral Sciences
Xin Jin, Kai Guan, Zhengyu Chen, Yongwei Sun, Hongjun Huo, Jinle Wang, Huihui Dong
Summary: The study found that nesfatin-1 promotes neurological recovery in SCI mice by reducing lesion area volume and spinal cord water content, improving behavioral scores, reducing oxidative stress, and preventing neuronal apoptosis. Additionally, nesfatin-1 can reduce inflammatory cytokine levels and promote the activation of M2 microglia.
BRAIN AND BEHAVIOR
(2022)
Article
Medicine, General & Internal
Tao Peng, Hongyu Li, Zhao Hu, Lejin Yang, Xiangdong Yang
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2015)
Article
Behavioral Sciences
Ai-hua Cao, Lin Yu, Yu-wei Wang, Jun-mei Wang, Le-jin Yang, Ge-fei Lei
BEHAVIORAL AND BRAIN FUNCTIONS
(2012)
Article
Cell Biology
Hongluan Yu, Cuiqin Fan, Lejin Yang, Shuyan Yu, Qiqi Song, Peng Wang, Xueqin Mao
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Allergy
Yanxia Lu, Meng Liu, Shousen Shi, Hong Jiang, Lejin Yang, Xin Liu, Qian Zhang, Fang Pan
Article
Neurosciences
Xin Liu, Le Jin Yang, Shu Juan Fan, Hong Jiang, Fang Pan
NEUROSCIENCE LETTERS
(2010)
Article
Neurosciences
Le Jin Yang, Xin Liu, De Xiang Liu, Hong Jiang, Xue Qin Mao, Chao Wang, Fang Pan
NEUROSCIENCE LETTERS
(2012)
Article
Psychiatry
Lei Li, Tianci Peng, Rui Liu, Ronghuan Jiang, Dongfeng Liang, Xiangping Li, Aihua Ni, Huan Ma, Xianwen Wei, Hanxiang Liu, Jing Zhang, Hengfen Li, Jianyue Pang, Yunxin Ji, Li Zhang, Yin Cao, Yun Chen, Bo Zhou, Jinny Wang, Xueqin Mao, Lejin Yang, Jianqun Fang, Honglan Shi, Aiqin Wu, Yonggui Yuan
GENERAL HOSPITAL PSYCHIATRY
(2020)
Article
Psychology, Multidisciplinary
Xinting Zhang, Lexia Yang, Wei Wang, Lejin Yang
Summary: This study aims to understand psychosocial factors that affect men with temporary ejaculation failure (TEF) in IVF-ET patients and provide new ideas for clinical treatment. The study found that psychological distress and neuroticism were risk factors for TEF, while cognitive reappraisal and sexual relationship were protective factors.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Immunology
Xiaorong Yang, Lejin Yang, Tongchao Zhang, Hong Zhang, Hui Chen, Xiuli Zuo
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Psychiatry
Zhen Li, Lejin Yang, Hui Chen, Yuan Fang, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Xiaorong Yang, Ming Lu
Summary: The aim of this systematic analysis is to summarize the current burden and temporal trends of autism spectrum disorder (ASD) globally, regionally, and nationally. The results indicate that the global burden of ASD is increasing and there are heterogeneities in burden across different regions and genders.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2022)
Article
Psychiatry
Xiaorong Yang, Yuan Fang, Hui Chen, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Lejin Yang, Ming Lu
Summary: Anxiety disorders are a widespread global issue, with significant disparities in burden and trends among different genders, regions, and age groups. Effective mental health knowledge dissemination and intervention strategies tailored to specific characteristics can help reduce the burden of anxiety disorders.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2021)