Review
Biochemistry & Molecular Biology
Kazunori Kageyama, Yasumasa Iwasaki, Makoto Daimon
Summary: This review focuses on the molecular mechanisms of CRF regulation in the hypothalamus during stress and stress resilience, highlighting the central role of CRF in regulating the stress response. The involvement of ACTH, glucocorticoids, various regulatory factors, and different CRF receptors in stress resilience are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Mengke Song, Longfei Jiang, Dayi Zhang, Zilin Huang, Shaorui Wang, Weiping Mei, Chunling Luo, Gan Zhang
Summary: The study found that the presence of different concentrations of copper (Cu) had varying effects on PFOS, with low concentrations causing an increase in PFOS concentration in roots and high concentrations damaging root cell membranes and increasing root permeability. It was also observed that Cu inhibition of carrier proteins could lead to the suppression of acropetal translocation of PFOS, and the presence of a protein-mediated uptake pathway was evidenced by enantiomer fraction (EF) results.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Environmental Sciences
Samuel Krebsbach, Jianzhou He, Sushil Adhikari, Yaniv Olshansky, Farshad Feyzbar, Leonard C. Davis, Tae-Sik Oh, Dengjun Wang
Summary: Biochar is a cost-effective solution for removing per- and polyfluoroalkyl substances (PFAS) from water, but the specific physicochemical properties of biochars that determine their PFAS removal remain unknown. In this study, 15 biochars were produced from five feedstocks at three pyrolysis temperatures to investigate their removal efficiency of perfluorooctane sulfonate (PFOS), a type of PFAS, from water. It was found that biochar pore diameter was the most critical factor for PFOS removal, but other factors such as pore diameter/pore volume ratio, specific surface area, pyrolysis temperature, hydrophobicity, and elemental composition also played roles. Biochars with small pore diameter, low nitrogen content, and high pyrolysis temperature showed enhanced PFOS sorption. These findings contribute to the understanding of using biochars with optimized properties to remove PFAS compounds from water.
Review
Environmental Sciences
Pingwei Wang, Dongge Liu, Shuqi Yan, Jiajing Cui, Yujun Liang, Shuping Ren
Summary: This study reviews the adverse effects of PFOS on liver tissue and function, providing a reference for further research on the toxicity of PFOS and liver injury caused by PFOS.
Article
Engineering, Environmental
Pengyang Li, Jiang Sun, Xiaocan Xie, Zhifang Li, Baoyong Huang, Guoguang Zhang, Jiuyi Li, Zhiyong Xiao
Summary: Limited understanding of stress response and tolerance to perfluorooctane sulfonate (PFOS) in plants exists at physiological, biochemical, and molecular levels. Lettuce exposed to PFOS showed accumulation of PFOS in leaves and roots, with different reactive oxygen species (ROS) production and defensive mechanisms observed between the two parts. Multiple defensive strategies in roots contribute to the high tolerance to PFOS.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Pingwei Wang, Dongge Liu, Shuqi Yan, Yujun Liang, Jiajing Cui, Li Guo, Shuping Ren, Peng Chen
Summary: This study demonstrates for the first time that PFOS induces ferroptosis in HK-2 cells. Additionally, the involvement of endoplasmic reticulum stress, apoptotic mechanism, and P53-mediated antioxidant mechanism in PFOS-induced cytotoxic damage are explored. These findings provide new insights into the toxicity of PFOS and its impact on kidney damage and mechanisms.
Article
Environmental Sciences
Manjurul Islam Chowdhury, Tanmoy Sana, Logeshwaran Panneerselvan, Anithadevi Kenday Sivaram, Mallavarapu Megharaj
Summary: This study investigated the toxicity of PFOS on the behavioral responses of C. elegans, and for the first time found its transgenerational effects. The results showed that PFOS severely affected locomotion and brood size, but these defects were rectified in the progeny after a few generations. Furthermore, PFOS also affected lifespan and chemotaxis plasticity.
Article
Engineering, Environmental
Zhuyu Sun, Chaojie Zhang, Jinchi Jiang, Jin Wen, Qi Zhou, Michael R. Hoffmann
Summary: A UV photoreductive system based on Fe(II)NTA is effective in decomposing PFOS at pH 8.0 under anoxic conditions, with degradation and defluorination efficiencies of around 60% and 29.5%, respectively. Laser flash photolysis and TDDFT calculations reveal a mechanism of UV-induced directional electron transfer from Fe(II)NTA to PFOS in a penta-coordinated metal-ligand complex.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Environmental Sciences
Shu Yu, Wen-Ru Feng, Zi-Mian Liang, Xiao-Yun Zeng, Michael S. Bloom, Guo-Cheng Hu, Yang Zhou, Yan-Qiu Ou, Chu Chu, Qing-Qing Li, Yunjiang Yu, Xiao-Wen Zeng, Guang-Hui Dong
Summary: The study found that higher serum PFAS concentrations were associated with an increased risk of MetS, showing a significant dose-response trend, particularly impacting women.
ENVIRONMENTAL POLLUTION
(2021)
Article
Oncology
Vicky C. C. Chang, Jongeun Rhee, Sonja I. I. Berndt, Steven C. C. Moore, Neal D. D. Freedman, Rena R. R. Jones, Debra T. T. Silverman, Gretchen L. L. Gierach, Jonathan N. N. Hofmann, Mark P. P. Purdue
Summary: In this nested case-control study, prediagnostic serum levels of PFOS and PFOA were found to be associated with breast cancer risk, particularly for hormone receptor-positive tumors, providing evidence of a possible positive association.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Environmental Sciences
Kurt A. Gust, J. Erik Mylroie, Ashley N. Kimble, Mitchell S. Wilbanks, Catherine S. C. Steward, Kacy A. Chapman, Kathleen M. Jensen, Alan J. Kennedy, Paige M. Krupa, Scott A. Waisner, Zacharias Pandelides, Natalia Garcia-Reyero, Russell J. Erickson, Gerald T. Ankley, Jason Conder, David W. Moore
Summary: This study investigated the multigenerational effects of perfluorooctane sulfonic acid (PFOS) exposure in zebrafish. Results showed that the adverse effects reported at concentrations lower than 1 μg/L in previous research were difficult to replicate. However, adverse effects at concentrations below 117 μg/L were observed, indicating an ecologically relevant threshold.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Erin Faught, Mathilakath M. Vijayan
Summary: The study demonstrates that the CRH/CRHR1 system mediates stress-induced hyperactivity, while the temporal activation of cortisol production and associated GR/MR signaling are crucial for prolonging stressor-induced hyperactivity.
NEUROENDOCRINOLOGY
(2022)
Article
Engineering, Environmental
Zhuyu Sun, Dan Geng, Chaojie Zhang, Jiabin Chen, Xuefei Zhou, Yalei Zhang, Qi Zhou, R. Michael Hoffmann
Summary: The study found that sulfide and vitamin B12 can effectively catalyze the decomposition and defluorination of PFOS, with the primary products being F- and polyfluorinated sulfonates and carboxylates. The reaction is strongly dependent on temperature and alkaline conditions.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Zhiru Wang, Jingzhi Yao, Hua Guo, Nan Sheng, Yong Guo, Jiayin Dai
Summary: This study found that H-PFMO2OSA induced higher levels of liver damage and more serious glutathione (GSH) metabolism dysregulation compared to PFOS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Environmental Sciences
Zacharias Pandelides, Jennifer Arblaster, Jason Conder
Summary: This study reviews the toxicity benchmarks of perfluorooctane sulfonate (PFOS) on zebrafish and suggests that chronic effects on reproduction, growth, and lethality occur at concentrations higher than 0.7 μg/L. Therefore, higher screening levels should be used to develop PFOS aquatic life criteria.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Review
Chemistry, Analytical
M. Fraga-Corral, M. Carpena, P. Garcia-Oliveira, A. G. Pereira, M. A. Prieto, J. Simal-Gandara
Summary: Metabolomics is a young field of knowledge that seeks to understand metabolites and their mechanisms of action. Various techniques such as NMR, MS, and VS are used to study the metabolome of biological samples. Each technique has its own advantages and limitations, and the choice depends on the research objectives and nature of the samples. Metabolomics has applications in environmental, food, and health sciences, and its growth is supported by advances in analytical techniques and integration with other omics.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Letter
Rheumatology
Sindhu R. Johnson, Martin Aringer
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Food Science & Technology
P. Garcia-Oliveira, M. Fraga-Corral, A. G. Pereira, M. A. Prieto, J. Simal-Gandara
Summary: Due to population growth, there are concerns about whether the current food system can provide enough healthy food for 10 billion people by 2050. This article discusses problems in food production and consumption, and offers potential solutions to promote sustainability and healthy diets.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Sport Sciences
Carla Goncalves, Pedro Bezerra, Filipe Manuel Clemente, Carolina Vila-Cha, Cesar Leao, Antonio Brandao, Jose M. Cancela
Summary: This study aimed to analyze the effects of a nine-week unstable vs stable bodyweight neuromuscular training program on balance control. The results showed that there were no significant differences in static balance control improvement between using unstable or stable surfaces in physically active universitarians.
RESEARCH IN SPORTS MEDICINE
(2022)
Article
Cell Biology
Daniela Rodrigues-Amorim, Tania Rivera-Baltanas, Patricia Fernandez-Palleiro, Marta Iglesias-Martinez-Almeida, Luis Freiria-Martinez, Cynthia Jarmardo-Rodriguez, Maria del Carmen Vallejo-Curto, Maria Alvarez-Ariza, Marta Lopez-Garcia, Elena de las Heras, Alejandro Garcia-Caballero, Jose Manuel Olivares, Carlos Spuch
Summary: The study found significant abnormalities in the composition and expression of brain extracellular matrix (ECM) proteins in patients with schizophrenia, which may lead to impaired neuronal function and neurodegenerative processes. The brain ECM and its components are potential pharmacological targets for developing new therapeutic approaches to treat schizophrenia.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Infectious Diseases
Adriana Solo-Peleteiro, Patricia Dieguez, Maria Teresa Perez-Rodriguez, Raul A. Galarraga, Antonio Perez-Landeiro, Maximiliano Alvarez-Fernandez
Summary: The study analyzed the clinical and microbiological characteristics of adult patients with cerebrospinal fluid (CSF) drainage-related ventriculitis. The results showed a high number of ventriculitis cases caused by multidrug-resistant organisms, highlighting the importance of judicious use of antibiotics.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2022)
Review
Biology
Ramon C. Hermida, Artemio Mojon, Jose R. Fernandez, Ramon G. Hermida-Ayala, Juan J. Crespo, Maria T. Rios, Manuel Dominguez-Sardina, Alfonso Otero, Michael H. Smolensky
Summary: Elevated asleep blood pressure and blunted sleep-time relative systolic blood pressure decline are significant prognostic markers of cardiovascular disease risk. Current hypertension guidelines overlook the importance of asleep blood pressure and recommend diagnosis based on office blood pressure measurements. Studies have shown that taking blood pressure-lowering medications at bedtime results in greater reduction of blood pressure and improved cardiovascular outcomes compared to morning intake.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Ignacio J. Amat-Santos, Juan P. Sanchez-Luna, Emad Abu-Assi, Maria Melendo-Viu, Ignacio Cruz-Gonzalez, Luis Nombela-Franco, Antonio J. Munoz-Garci, Sergio G. Blas, Jose M. de la Torre Hernandez, Rafael Romaguera, Angel Sanchez-Recalde, Jose L. Diez-Gil, Diego Lopez-Otero, Livia Gheorge, Borja Ibanez, Andres Iniguez-Romo, Sergio Raposeiras-Roubin
Summary: The DapaTAVI trial aims to evaluate the efficacy and safety of dapagliflozin in patients with severe AS undergoing TAVI. Candidate patients should have prior history of HF admission and meet criteria such as diabetes mellitus, reduced left ventricular ejection fraction, or certain estimated glomerular filtration rate. The trial will involve 1020 patients who will be randomized to receive dapagliflozin or no dapagliflozin, with key secondary outcomes including HF hospitalization, cardiovascular mortality, and total number of HF rehospitalizations.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Luis Marroquin, Gabriela Tirado-Conte, Radoslaw Praco, Witold Streb, Hipolito Gutierrez, Giacomo Boccuzzi, Dabit Arzamendi-Aizpurua, Ignacio Cruz-Gonzalez, Juan Miguel Ruiz-Nodar, Jung-Sun Kim, Xavier Freixa, Jose Ramon Lopez-Minguez, Ole De Backer, Rafael Ruiz-Salmeron, Antonio Dominguez, Angela McInerney, Vicente Peral, Rodrigo Estevez-Loureiro, Eduard Fernandez-Nofrerias, Afonso B. Freitas-Ferraz, Francesco Saia, Zenon Huczek, Livia Gheorghe, Pablo Salinas, Marcin Demkow, Jose R. Delgado-Arana, Estefania Fernandez Peregrina, Zbibniew Kalarus, Ana Elvira Laffond, Yangsoo Jang, Jose Carlos Fernandez Camacho, Oh-Hyun Lee, Jose M. Hernandez-Garcia, Caterina Mas-Llado, Berenice Caneiro Queija, Ignacio J. Amat-Santos, Maciej Dabrowski, Josep Rodes-Cabau, Luis Nombela Franco
Summary: This study analyzed the medical and invasive treatment of patients referred for LAAC in the presence of LAA thrombus. The initial preferred strategy was IAT, with a relatively high thrombus resolution rate but also a higher bleeding rate. Direct LAAC was found to be feasible with high procedural success, but a high rate of device-related thrombosis was detected during follow-up.
Review
Gastroenterology & Hepatology
Vincenzo Vigorita, Oscar Cano-Valderrama, Valerio Celentano, Danilo Vinci, Monica Millan, Antonino Spinelli, Gianluca Pellino
Summary: Evidence on ERAS in IBD is lacking, but this group of patients might benefit from consistent adoption of the pathway. Future studies should define if IBD-specific ERAS pathways and selection criteria are needed.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Engineering, Biomedical
S. Suarez, J. A. Lopez-Campos, A. Segade, C. G. Veiga, V. A. Jimenez
Summary: This study provides a comprehensive analysis on the influence of fiber orientation on the behavior of bioprosthetic aortic valve replacements. It highlights the sensitivity of the valve's behavior to small variations in the orientation angle of circumferential fibers, while emphasizing the importance of achieving behavior similar to axial fiber orientation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Computer Science, Artificial Intelligence
Ivan Rodriguez-Conde, Celso Campos, Florentino Fdez-Riverola
Summary: Convolutional neural networks have significantly advanced image analysis and computer vision research, particularly in the field of object detection. While cloud systems offer vast computational resources, they also pose challenges such as communication delays and security concerns. As a result, exploring on-device models has emerged as a promising alternative to achieve more efficient detection on resource-constrained devices.
NEURAL COMPUTING & APPLICATIONS
(2022)
Article
Health Care Sciences & Services
Eva Rodriguez-Miguez, Jacinto Mosquera Nogueira
Summary: The study estimated the impact of alcohol disorders using lottery equivalent and willingness to pay methods, with lottery equivalent method proving to be more sensitive. The Quality-Adjusted Life Years (QALY) impact of nine states of alcohol misuse ranged from 0.22 to 0.91, and the willingness to pay to avoid them varied from euro 10,444 to euro 4,132. Furthermore, the willingness to pay for a QALY ranged from euro 11,473 to euro 19,092, with a tendency to decrease with severity.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2022)
Article
Microbiology
Erick Martinez-Herrera, Maria Guadalupe Frias-De-Leon, Rigoberto Hernandez-Castro, Eduardo Garcia-Salazar, Roberto Arenas, Esther Ocharan-Hernandez, Carmen Rodriguez-Cerdeira
Summary: There is variability in the rates of resistance to antifungal agents in Candida glabrata in different regions worldwide. Limited data are available on the antifungal resistance in C. glabrata in Ibero-America. A systematic review was conducted to determine the antifungal resistance in C. glabrata in this region over the last five years. The use of azoles and echinocandins varied among different countries. The limited information emphasizes the need for species identification and antifungal susceptibility tests to prevent the development of antifungal resistance.
Article
Biochemical Research Methods
Hugo Lopez-Fernandez, Pedro Duque, Noe Vazquez, Florentino Fdez-Riverola, Miguel Reboiro-Jato, Cristina P. Vieira, Jorge Vieira
Summary: SEDA is a multiplatform desktop application used for manipulating FASTA files containing DNA or protein sequences. It provides a range of simple and advanced tools for life science researchers working with DNA and protein sequences. This paper presents guidelines on building efficient data handling protocols using SEDA and offers practical examples. SEDA is user-friendly and capable of managing large datasets.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2022)
