Article
Chemistry, Medicinal
Daneng Wei, Yafei Zhao, Mengmeng Zhang, Lei Zhu, Li Wang, Xing Yuan, Chunjie Wu
Summary: The study showed that volatile oil of Zanthoxylum bungeanum had an ameliorative effect on anxiety behavior induced by chronic unpredictable stress, potentially through inhibiting HPA axis activation and restoring dysbiosis of gut microbiota. This finding provides a potential therapeutic strategy for stress-induced abnormalities in the microbiota-gut-brain axis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Oncology
Yinxian Wen, Siyuan Cheng, Juan Lu, Xia He, Zhexiao Jiao, Dan Xu, Hui Wang
Summary: Prenatal food restriction (PFR) leads to dysfunction of the HPA axis in adult offspring, characterized by hypothalamic hyperexcitability and poor hippocampal feedback, which affect the behavior of the rat offspring.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jian Zhong Yang, Chuan Yuan Kang, Jing Yuan, Yan Zhang, Yu Jun Wei, Li Xu, Fang Zhou, Xinxin Fan
Summary: This study highlighted that patients with major depressive disorder (MDD) who experienced adverse childhood experiences (ACEs) showed differences in hypothalamic-pituitary-adrenal (HPA) axis function and symptom severity compared to those without ACEs. ACEs, ACTH, and COR could serve as predictors for long-term antidepressant treatment, suggesting that they may be poor prognostic indicators for MDD patients with ACEs.
PSYCHONEUROENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Rok Herman, Andrej Janez, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Derek Schaeuble, Brent Myers
Summary: This article reviews the emerging literature on how specific cortical and hypothalamic nuclei regulate cardiovascular and neuroendocrine stress responses, as well as the cellular and circuit mechanisms mediating physiological stress responses. The reviewed literature highlights the current state of stress integration research and raises unanswered questions about the brain basis of CVD risk.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bei Zhou, Qilong Xu, Junjie Guo, Qinliang Chen, Qingqing Lv, Kan Xiao, Huiling Zhu, Jiangchao Zhao, Yulan Liu
Summary: This study investigates the role of necroptosis in the activation of the hypothalamic-pituitary-adrenal (HPA) axis in a stress model induced by Escherichia coli lipopolysaccharide (LPS). The findings indicate that necroptosis is present and contributes to HPA axis activation induced by LPS. Necroptosis may serve as a potential intervention target for alleviating HPA axis activation and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xiang Pan, Kezhuo Chen, Sijie Han, Xinyao Luo, Dandan Zhang, Hanrui Zhang, Lian Zhang, Xuxiang Zhou, Jing Li, Jingxian Fang, Shiqin Wang, Xiaochuan Ye
Summary: This study aimed to investigate the antidepressant-like effects of total triterpenes of Wolfiporia cocos (TTWC) and explore their specific mechanisms of action in depth. Chemical components of TTWC were analyzed using LC-MS. Depression-like behavior in rats induced by chronic unpredictable mild stress (CUMS) was evaluated using various tests. The levels of neurotransmitters and inflammatory cytokines, as well as the expression of NLRP3 signaling pathway-related proteins, were determined to further understand the mechanisms of TTWC.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Ping Liu, Shiyuan Song, Ping Yang, Xiuming Rao, Yuqi Wang, Xinyu Bai
Summary: Eucommia ulmoides Oliv (EUO) is a traditional therapeutic drug that can tonify the liver and kidney and improve depression. The main component, aucubin (AU), has unknown mechanisms of action. By using a depression model in mice, we found that AU administration reversed the changes in neuronal regeneration, axonal damage, hormonal changes, inflammation, glucocorticoid receptor expression, and pyroptosis induced by chronic unpredictable mild stress (CUMS). It improved the depression-like behavior in mice.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Feiye Wu, Jing Zhu, Yang Wan, Subinuer Kurexi, Jia Zhou, Ke Wang, Tongyu Chen
Summary: This study aimed to investigate the effects of electroacupuncture (EA) on the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and its potential mechanisms. The results showed that EA treatment effectively inhibited the hyperactivity of the HPA axis and promoted postoperative recovery by activating the oxytocin/oxytocin receptor (OXT/OXTR) signaling pathway.
NEUROCHEMICAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Cell Biology
Manxiu Ma, Alyssa A. Brunal, Kareem C. Clark, Carleigh Studtmann, Katelyn Stebbins, Shin-ichi Higashijima, Y. Albert Pan
Summary: The expression of corticotropin-releasing hormone (CRH) in the hypothalamus plays a critical role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the stress response. Through studying zebrafish, researchers identified dscaml1 as an important factor in CRH neuron development and HPA axis function. Mutations in dscaml1 led to increased CRH expression and cell number in hypothalamic CRH neurons, as well as altered stress hormone levels and response to stressors. These findings suggest a role for dscaml1 in stress axis development and its potential contribution to neuropsychiatric disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Sergi Olvera-Maneu, Anais Carbajal, Jaume Gardela, Manel Lopez-Bejar
Summary: Monitoring the endocrine status of horses through hair samples can provide valuable information on their welfare and reproductive health. This study found that cortisol, testosterone, and dehydroepiandrosterone sulphate levels in horse hair were significantly influenced by season, with varying hormone ratios between seasons. Seasonality should be considered when analyzing sexual and stress hormones in stallion hair to avoid misinterpretations.