Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis

Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis

(2020) Xing Zeng et al.   Nutrition & Metabolism

Hepatic FNDC5 is a potential local protective factor against Non-Alcoholic Fatty Liver

(2020) Clémence M. Canivet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lytic cell death in metabolic liver disease

(2020) Jérémie Gautheron et al.   JOURNAL OF HEPATOLOGY

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

(2020) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

What's in a name? Renaming ‘NAFLD’ to ‘MAFLD’

(2020) Yasser Fouad et al.   LIVER INTERNATIONAL

Recent advances in siRNA delivery mediated by lipid-based nanoparticles

(2020) Sei Yonezawa et al.   ADVANCED DRUG DELIVERY REVIEWS

Prominent Receptors of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease

(2020) Ekta Pandey et al.   Frontiers in Physiology

A closer look of the mysterious HSD17B13

(2020) X. Charlie Dong   JOURNAL OF LIPID RESEARCH

Potential roles of bone morphogenetic protein-9 in glucose and lipid homeostasis

(2020) Yichao Wang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

SB431542-Loaded Liposomes Alleviate Liver Fibrosis by Suppressing TGF-β Signaling

(2020) Jinhang Zhang et al.   MOLECULAR PHARMACEUTICS

Diabetic fibrosis

(2020) Izabela Tuleta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NAFLD : Reporting Histologic Findings in Clinical Practice

(2020) Elizabeth M. Brunt et al.   HEPATOLOGY

The Role of Innate Immune Cells in Nonalcoholic Steatohepatitis

(2019) Jingjing Cai et al.   HEPATOLOGY

LSEC Fenestrae Are Preserved Despite Pro-inflammatory Phenotype of Liver Sinusoidal Endothelial Cells in Mice on High Fat Diet

(2019) Edyta Kus et al.   Frontiers in Physiology

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

(2019) Kalina Paunovska et al.   ADVANCED MATERIALS

BMP 9 is a paracrine factor controlling liver sinusoidal endothelial cell fenestration and protecting from hepatic fibrosis

(2019) Agnès Desroches‐Castan et al.   HEPATOLOGY

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

(2019) Soumik BasuRay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

(2019) Daniel Lindén et al.   Molecular Metabolism

The role of senescence in the development of non-alcoholic fatty liver disease and progression to non-alcoholic steatohepatitis

(2019) Alkistis-Maria Papatheodoridi et al.   HEPATOLOGY

The Global Epidemiology of NAFLD and NASH in Patients with type 2 diabetes: A Systematic Review and Meta-analysis

(2019) Zobair M. Younossi et al.   JOURNAL OF HEPATOLOGY

Free radicals, antioxidants, nuclear factor‐E2‐related factor‐2 and liver damage

(2019) Erika Ramos‐Tovar et al.   JOURNAL OF APPLIED TOXICOLOGY

Lgr5+ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis

(2019) Chow Hiang Ang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Consequences of Bmp9 Deletion on Sinusoidal Endothelial Cell Differentiation and Liver Fibrosis in 129/Ola and C57BL/6 Mice

(2019) Agnès Desroches-Castan et al.   Cells

Stabilin Receptors: Role as Phosphatidylserine Receptors

(2019) Seung-Yoon Park et al.   Biomolecules

TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019

(2019) Dewidar et al.   Cells

Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration

(2019) Feng Chen et al.   Cell Stem Cell

Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC–ERK1/2–AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet

(2019) Lingyan Ye et al.   JOURNAL OF NUTRITION

Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis

(2019) Olga Khomich et al.   Cells

Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake

(2018) Frederick Campbell et al.   ACS Nano

MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis

(2018) Qiaozhu Su et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis

(2018) Peng Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

(2018) Tatsuya Yamada et al.   Cell Metabolism

The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease

(2018) Misaki Matsumoto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis

(2018) Giovanni Musso et al.   GASTROENTEROLOGY

Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation

(2018) Samar H Ibrahim et al.   GUT

Hedgehog signalling in liver pathophysiology

(2018) Mariana Verdelho Machado et al.   JOURNAL OF HEPATOLOGY

Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α

(2018) Denisse Sepulveda et al.   MOLECULAR CELL

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Triggering and resolution of inflammation in NASH

(2018) Susanne Schuster et al.   Nature Reviews Gastroenterology & Hepatology

Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction

(2018) Michelle L Boland et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study

(2018) Elliot B Tapper et al.   BMJ-British Medical Journal

Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study

(2018) Elliot B Tapper et al.   BMJ-British Medical Journal

Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease

(2018) Peter R. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of BMP-9 in human liver disease

(2018) Miya John et al.   GUT

HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease

(2018) Yanling Ma et al.   HEPATOLOGY

Indian Hedgehog links obesity to development of hepatocellular carcinoma

(2018) Yong Chun Chong et al.   ONCOGENE

BMP-9 interferes with liver regeneration and promotes liver fibrosis

(2017) Katja Breitkopf-Heinlein et al.   GUT

Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance

(2017) Melania Gaggini et al.   HEPATOLOGY

Asialoglycoprotein receptor-targeted liposomes loaded with a norcantharimide derivative for hepatocyte-selective targeting

(2017) Xiaolin Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

Activation of the Unfolded Protein Response by Lipid Bilayer Stress

(2017) Kristina Halbleib et al.   MOLECULAR CELL

Nanovesicle delivery to the liver via retinol binding protein and platelet-derived growth factor receptors: how targeting ligands affect biodistribution

(2017) Ching-Yun Hsu et al.   Nanomedicine

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4

(2017) Guang-Nian Zhao et al.   NATURE MEDICINE

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

(2017) Michael Tanowitz et al.   NUCLEIC ACIDS RESEARCH

Dysregulation of redox pathways in liver fibrosis

(2016) Natalie J. Torok   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children

(2016) David E. Kleiner et al.   Clinics in Liver Disease

TGF-β signalling and liver disease

(2016) Isabel Fabregat et al.   FEBS Journal

Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2

(2016) Ja Hyun Koo et al.   GASTROENTEROLOGY

Pathogenesis of Nonalcoholic Steatohepatitis

(2016) Mariana Verdelho Machado et al.   GASTROENTEROLOGY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2016) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate

(2016) Hiroyuki Nojima et al.   JOURNAL OF HEPATOLOGY

Sinusoidal communication in liver fibrosis and regeneration

(2016) Giusi Marrone et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease and diabetes

(2016) Jonathan M. Hazlehurst et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

NAFLD and diabetes mellitus

(2016) Herbert Tilg et al.   Nature Reviews Gastroenterology & Hepatology

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways

(2016) Kunxin Luo   Cold Spring Harbor Perspectives in Biology

Spacer Length: A Determining Factor in the Design of Galactosyl Ligands for Hepatoma Cell-Specific Liposomal Gene Delivery

(2016) Londiwe Mbatha et al.   Current Drug Delivery

RNAi in murine hepatocytes: the agony of choice—a study of the influence of lipid-based transfection reagents on hepatocyte metabolism

(2015) Jan Böttger et al.   ARCHIVES OF TOXICOLOGY

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Non-Alcoholic Steatohepatitis: Limited Available Treatment Options but Promising Drugs in Development and Recent Progress Towards a Regulatory Approval Pathway

(2015) Claudia Filozof et al.   DRUGS

Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease

(2015) N. U. Ashraf et al.   FREE RADICAL RESEARCH

Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease

(2015) Chiara Rosso et al.   HEPATOLOGY

Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease

(2015) Mariana Verdelho Machado et al.   JOURNAL OF HEPATOLOGY

Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity

(2015) Sanda Win et al.   JOURNAL OF HEPATOLOGY

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression

(2015) Masashi Miyao et al.   LABORATORY INVESTIGATION

The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship

(2015) Boris Hinz   MATRIX BIOLOGY

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Fibrosis in Nonalcoholic Fatty Liver Disease: Mechanisms and Clinical Implications

(2015) Paul Angulo et al.   SEMINARS IN LIVER DISEASE

Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis

(2014) Qiaozhu Su et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nonalcoholic fatty liver disease: A main driver of insulin resistance or a dangerous liaison?

(2014) Nanda Gruben et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis

(2014) M V Machado et al.   GUT

Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice

(2014) Pedro Elias Marques et al.   HEPATOLOGY

Biomarkers of liver cell death

(2014) Akiko Eguchi et al.   JOURNAL OF HEPATOLOGY

Smad2 protects against TGF-β1/Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic fibrosis

(2014) Lei Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

(2014) Markus Dahl et al.   PLoS One

Formation of Fenestrae in Murine Liver Sinusoids Depends on Plasmalemma Vesicle-Associated Protein and Is Required for Lipoprotein Passage

(2014) Leonie Herrnberger et al.   PLoS One

Nitric oxide is a potential mediator of hepatic inflammation and fibrogenesis in autoimmune hepatitis

(2014) Yavuz Beyazit et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Pediatric non-alcoholic steatohepatitis: The first report on the ultrastructure of hepatocyte mitochondria

(2014) Joanna M Lotowska   WORLD JOURNAL OF GASTROENTEROLOGY

Role of Toll-Like Receptors in Immune Activation and Tolerance in the Liver

(2014) Nobuhiro Nakamoto et al.   Frontiers in Immunology

Inhibition of Hedgehog signaling in the gastrointestinal tract: Targeting the cancer microenvironment

(2013) Juanita L. Merchant et al.   CANCER TREATMENT REVIEWS

Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy

(2013) M Swiderska-Syn et al.   GUT

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease

(2013) Cynthia A. Moylan et al.   HEPATOLOGY

Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice

(2013) Guanhua Xie et al.   HEPATOLOGY

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH

(2013) Salvatore Sutti et al.   HEPATOLOGY

Nonalcoholic Fatty Liver Disease: A Novel Cardiometabolic Risk Factor for Type 2 Diabetes and Its Complications

(2013) Giovanni Targher et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of the Hedgehog pathway in hepatocellular carcinoma (Review)

(2013) XIN ZHENG et al.   ONCOLOGY REPORTS

Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: Possible therapeutic targets?

(2013) Luc Rochette et al.   PHARMACOLOGY & THERAPEUTICS

Secretion and Signaling Activities of Lipoprotein-Associated Hedgehog and Non-Sterol-Modified Hedgehog in Flies and Mammals

(2013) Wilhelm Palm et al.   PLOS BIOLOGY

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Role of inducible nitric oxide synthase in mitochondrial depolarization and graft injury after transplantation of fatty livers

(2012) Qinlong Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications

(2012) Kenneth Cusi   GASTROENTEROLOGY

Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation

(2012) Guanhua Xie et al.   GUT

FOXO1 involvement in insulin resistance-related pro-inflammatory cytokine production in hepatocytes

(2012) Hongming Miao et al.   INFLAMMATION RESEARCH

Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease

(2012) Aloysious Aravinthan et al.   JOURNAL OF HEPATOLOGY

Effect of RhoA on transforming growth factor β1-induced rat hepatic stellate cell migration

(2012) Lei Li et al.   LIVER INTERNATIONAL

Macrophage-derived hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni

(2012) Thiago A. Pereira et al.   LIVER INTERNATIONAL

miRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytes

(2012) Z. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis and Evaluation of Stearylated Hyaluronic Acid for the Active Delivery of Liposomes to Liver Endothelial Cells

(2011) Naoyuki Toriyabe et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

The Src Family Kinase Inhibitors PP2 and PP1 Block TGF-Beta1-Mediated Cellular Responses by Direct and Differential Inhibition of Type I and Type II TGF-Beta Receptors

(2011) H. Ungefroren et al.   CURRENT CANCER DRUG TARGETS

Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease

(2011) D. M. S. Ferreira et al.   DIABETOLOGIA

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease

(2011) Cynthia D. Guy et al.   HEPATOLOGY

Increased production of sonic hedgehog by ballooned hepatocytes

(2011) Fatima Rangwala et al.   JOURNAL OF PATHOLOGY

Autophagy in nonalcoholic steatohepatitis

(2011) Muhammad Amir et al.   Expert Review of Gastroenterology & Hepatology

Apolipoprotein B: not just a biomarker but a causal factor in hepatic endoplasmic reticulum stress and insulin resistance

(2010) Qiaozhu Su et al.   Clinical Lipidology

In Vitro-Derived Alternatively Activated Macrophages Reduce Colonic Inflammation in Mice

(2010) Meaghan M. Hunter et al.   GASTROENTEROLOGY

Liver sinusoidal endothelium: A microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1

(2010) Cyrill Géraud et al.   HEPATOLOGY

Age-Related Changes in Scavenger Receptor–Mediated Endocytosis in Rat Liver Sinusoidal Endothelial Cells

(2010) Jaione Simon-Santamaria et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Apolipoprotein B100 acts as a molecular link between lipid-induced endoplasmic reticulum stress and hepatic insulin resistance

(2009) Qiaozhu Su et al.   HEPATOLOGY

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88

(2008) Istvan Hritz et al.   HEPATOLOGY

Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease

(2008) Janice Jou et al.   SEMINARS IN LIVER DISEASE

The liver sinusoidal endothelial cell: a cell type of controversial and confusing identity

(2007) Kjetil Elvevold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY