Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease

The Genetics of Pediatric Nonalcoholic Fatty Liver Disease

(2018) Nidhi P. Goyal et al.   Clinics in Liver Disease

Genetic variants in COL13A1, ADIPOQ and SAMM50 , in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed Mexican population

(2018) Elena Larrieta-Carrasco et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma

(2018) Igor P. Pogribny et al.   FASEB JOURNAL

The Effects of Physical Exercise on Fatty Liver Disease

(2018) Dirk J. van der Windt et al.   GENE EXPRESSION

Genetic Polymorphisms of PNPLA3 and SAMM50 Are Associated with Nonalcoholic Fatty Liver Disease in a Korean Population

(2018) Goh Eun Chung et al.   Gut and Liver

Genetic determinants of hepatic steatosis and serum cytokeratin-18 fragment levels in Taiwanese children

(2018) Yu-Cheng Lin et al.   LIVER INTERNATIONAL

Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression

(2018) Francesco Bellanti et al.   Redox Biology

In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice

(2017) Yoshinori Seki et al.   ENDOCRINOLOGY

Sex differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents

(2017) Oyekoya T. Ayonrinde et al.   HEPATOLOGY

Identification of the genomic region under epigenetic regulation during non-alcoholic fatty liver disease progression

(2017) Kikuko Hotta et al.   HEPATOLOGY RESEARCH

NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children

(2017) Miriam B. Vos et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

(2017) Kimberly P. Newton et al.   JOURNAL OF PEDIATRICS

Associations of cord blood metabolites with perinatal characteristics, newborn anthropometry, and cord blood hormones in project viva

(2017) Wei Perng et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies

(2017) Nishanth E. Sunny et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease

(2017) Martina Goffredo et al.   Nutrients

Altered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain

(2017) Peter R. Baker et al.   Scientific Reports

Liver-specific deletion of RORα aggravates diet-induced nonalcoholic steatohepatitis by inducing mitochondrial dysfunction

(2017) Hyeon-Ji Kim et al.   Scientific Reports

Pro-Inflammatory CXCR3 Impairs Mitochondrial Function in Experimental Non-Alcoholic Steatohepatitis

(2017) Jinghua Du et al.   Theranostics

Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants

(2017) Kristen E. Boyle et al.   Molecular Metabolism

Omega-3 PUFA modulate lipogenesis, ER stress, and mitochondrial dysfunction markers in NASH – Proteomic and lipidomic insight

(2017) Lívia Samara dos Reis Rodrigues Okada et al.   CLINICAL NUTRITION

Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations

(2017) Umesh D. Wankhade et al.   PLoS One

In vivo redox metabolic imaging of mitochondria assesses disease progression in non-alcoholic steatohepatitis

(2017) Ryosuke Nakata et al.   Scientific Reports

Maternal weight gain in excess of pregnancy guidelines is related to daughters being overweight 40 years later

(2016) L.C. Houghton et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high-fat diet-induced hepatic steatosis

(2016) E. Matthew Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD)

(2016) Salamah Mohammad Alwahsh et al.   ARCHIVES OF TOXICOLOGY

Non-alcoholic fatty liver disease (Nafld) in obese children- effect of refined carbohydrates in diet

(2016) Deise Rosa Félix et al.   BMC Pediatrics

Association of maternal diabetes/glycosuria and pre-pregnancy body mass index with offspring indicators of non-alcoholic fatty liver disease

(2016) Sumaiya Patel et al.   BMC Pediatrics

Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth

(2016) Denise M. Scholtens et al.   DIABETES

Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism

(2016) Wenhui Yang et al.   GENE

Nonalcoholic Fatty Liver Disease: Epidemiology, Natural History, and Diagnostic Challenges

(2016) George Cholankeril et al.   HEPATOLOGY

The globalization of nonalcoholic fatty liver disease: Prevalence and impact on world health

(2016) Mary Rinella et al.   HEPATOLOGY

Inactivation ofTm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins

(2016) Eriks Smagris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cord Blood Adipokines and Lipids and Adolescent Nonalcoholic Fatty Liver Disease

(2016) Joy Simpson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Overweight in late adolescence predicts development of severe liver disease later in life: A 39years follow-up study

(2016) Hannes Hagström et al.   JOURNAL OF HEPATOLOGY

Gestational exercise protects adult male offspring from high-fat diet-induced hepatic steatosis

(2016) Ryan D. Sheldon et al.   JOURNAL OF HEPATOLOGY

Amino Acid Metabolism is Altered in Adolescents with Nonalcoholic Fatty Liver Disease—An Untargeted, High Resolution Metabolomics Study

(2016) Ran Jin et al.   JOURNAL OF PEDIATRICS

Fructose consumption induces hypomethylation of hepatic mitochondrial DNA in rats

(2016) Mirai Yamazaki et al.   LIFE SCIENCES

Synergistic Effects of Cilostazol and Probucol on ER Stress-Induced Hepatic Steatosis via Heme Oxygenase-1-Dependent Activation of Mitochondrial Biogenesis

(2016) Yingqing Chen et al.   Oxidative Medicine and Cellular Longevity

Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study

(2016) Anna Viitasalo et al.   PEDIATRIC RESEARCH

SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids

(2016) Takamasa Tobita et al.   PLoS One

Prohibitin-induced, obesity-associated insulin resistance and accompanying low-grade inflammation causes NASH and HCC

(2016) Sudharsana R. Ande et al.   Scientific Reports

PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation

(2015) Qian Gao et al.   AMERICAN JOURNAL OF PATHOLOGY

Central effects of humanin on hepatic triglyceride secretion

(2015) Zhenwei Gong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project

(2015) Kristen E. Boyle et al.   DIABETES

Women With Gestational Diabetes Mellitus Randomized to a Higher–Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study

(2015) Teri L. Hernandez et al.   DIABETES CARE

Ursodeoxycholyl Lysophosphatidylethanolamide modifies aberrant lipid profiles in NAFLD

(2015) Anita Pathil et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study

(2015) Martina Goffredo et al.   HEPATOLOGY

Heme oxygenase-1 gene promoter polymorphism and the risk of pediatric nonalcoholic fatty liver disease

(2015) P-F Chang et al.   INTERNATIONAL JOURNAL OF OBESITY

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Sirt1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet

(2015) Xiaojun Liu et al.   JOURNAL OF HEPATOLOGY

Hepatic Steatosis Is Prevalent in Stillborns Delivered to Women With Diabetes Mellitus

(2015) Kalyani R. Patel et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease

(2015) Carlos J. Pirola et al.   MEDICINE

Detailed Analysis of the Human Mitochondrial Contact Site Complex Indicate a Hierarchy of Subunits

(2015) Christine Ott et al.   PLoS One

HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT

(2015) Shuo Wang et al.   PLoS One

Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease

(2015) Sulin Cheng et al.   PLoS One

Acute and perinatal programming effects of a fat-rich diet on rat muscle mitochondrial function and hepatic lipid accumulation

(2014) Lars I. Hellgren et al.   ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA

In utero exposure to a maternal high-fat diet alters the epigenetic histone code in a murine model

(2014) Melissa A. Suter et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity

(2014) Maria Z. Alfaradhi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

(2014) April D. Lake et al.   AMINO ACIDS

Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK

(2014) Hui Li et al.   Cardiovascular Diabetology

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Early Life Exposure to Maternal Insulin Resistance Has Persistent Effects on Hepatic NAFLD in Juvenile Nonhuman Primates

(2014) S. R. Thorn et al.   DIABETES

Mechanism for HIF-1 activation by cholesterol under normoxia: A redox signaling pathway for liver damage

(2014) Sarit Anavi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Plasma Levels of Homocysteine and Cysteine Increased in Pediatric NAFLD and Strongly Correlated with Severity of Liver Damage

(2014) Anna Pastore et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Accelerated Infant Weight Gain and Risk for Nonalcoholic Fatty Liver Disease in Early Adulthood

(2014) Laura M. Breij et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hepatic stellate cells contribute to progenitor cells and liver regeneration

(2014) Claus Kordes et al.   JOURNAL OF CLINICAL INVESTIGATION

Weight trajectories through infancy and childhood and risk of non-alcoholic fatty liver disease in adolescence: The ALSPAC study

(2014) Emma L. Anderson et al.   JOURNAL OF HEPATOLOGY

Comparative metabolome analysis of cultured fetal and adult hepatocytes in humans

(2014) Su-Ryang Kim et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

TheUCP2-866 G>A promoter region polymorphism is associated with nonalcoholic steatohepatitis.

(2014) Roberta Fares et al.   LIVER INTERNATIONAL

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

(2014) H. Mahdessian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-1α and HIF-2α are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1α-mediated fatty acid β-oxidation

(2014) Yanlong Liu et al.   TOXICOLOGY LETTERS

Pediatric non-alcoholic steatohepatitis: The first report on the ultrastructure of hepatocyte mitochondria

(2014) Joanna M Lotowska   WORLD JOURNAL OF GASTROENTEROLOGY

Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease

(2014) Giuseppe Paradies   WORLD JOURNAL OF GASTROENTEROLOGY

Maternal western diet primes non-alcoholic fatty liver disease in adult mouse offspring

(2013) M. G. M. Pruis et al.   Acta Physiologica

MnSOD in Oxidative Stress Response-Potential Regulation via Mitochondrial Protein Influx

(2013) Demet Candas et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells

(2013) Chia-Chi Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets

(2013) Valentina Giorgio et al.   BMC Pediatrics

Severe Obesity in Children and Adolescents: Identification, Associated Health Risks, and Treatment Approaches

(2013) Aaron S. Kelly et al.   CIRCULATION

Maternal Hypoxia Increases the Susceptibility of Adult Rat Male Offspring to High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease

(2013) Yi-Ming Su et al.   ENDOCRINOLOGY

Manganese superoxide dismutase is reduced in the liver of male but not female humans and rodents with non-alcoholic fatty liver disease

(2013) Sabrina Krautbauer et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

(2013) Susan K. Murphy et al.   GASTROENTEROLOGY

Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein

(2013) Yusuke Hirata et al.   GENES TO CELLS

Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice

(2013) Angelina Mouralidarane et al.   HEPATOLOGY

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

Therapeutic Effect of Metformin and Vitamin E Versus Prescriptive Diet in Obese Adolescents with Fatty Liver

(2013) Akcam et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Liver adapts mitochondrial function to insulin resistant and diabetic states in mice

(2013) Andras Franko et al.   JOURNAL OF HEPATOLOGY

Nonalcoholic fatty liver disease in severely obese adolescent and adult patients

(2013) Ai-Xuan L. Holterman et al.   Obesity

Mitochondrial Dysfunction Induces Formation of Lipid Droplets as a Generalized Response to Stress

(2013) Seon-Jin Lee et al.   Oxidative Medicine and Cellular Longevity

A common variant in the peroxisome proliferator–activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children

(2012) Yu-Cheng Lin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Nutrient sensor–mediated programmed nonalcoholic fatty liver disease in low birthweight offspring

(2012) Diana Wolfe et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Hepatic Insulin Signaling Changes: Possible Mechanism in Prenatal Hypoxia-Increased Susceptibility of Fatty Liver in Adulthood

(2012) Li Cao et al.   ENDOCRINOLOGY

A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates

(2012) Melissa A. Suter et al.   FASEB JOURNAL

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

Hypoxia-inducible factors and their roles in energy metabolism

(2012) Nobuhito Goda et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease

(2012) Naim Alkhouri et al.   JOURNAL OF HEPATOLOGY

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

(2012) Santhosh Satapati et al.   JOURNAL OF LIPID RESEARCH

Maternal high-fat intake during pregnancy programs metabolic-syndrome-related phenotypes through liver mitochondrial DNA copy number and transcriptional activity of liver PPARGC1A

(2012) Adriana Laura Burgueño et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Intrahepatic Fat Is Increased in the Neonatal Offspring of Obese Women with Gestational Diabetes

(2012) David E. Brumbaugh et al.   JOURNAL OF PEDIATRICS

Sam50 Functions in Mitochondrial Intermembrane Space Bridging and Biogenesis of Respiratory Complexes

(2012) C. Ott et al.   MOLECULAR AND CELLULAR BIOLOGY

Lower plasma NAMPT/visfatin levels are associated with impaired hepatic mitochondrial function in non-diabetic obese women: A potential link between obesity and non-alcoholic fatty liver disease

(2012) J.R. Ruiz et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Childhood Obesity Is Associated with Changes in the Serum Metabolite Profile

(2012) Simone Wahl et al.   Obesity Facts

Role of ceramides in nonalcoholic fatty liver disease

(2012) Mangesh Pagadala et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Early onset of fatty liver in growth-restricted rat fetuses and newborns

(2011) Makiko Yamada et al.   CONGENITAL ANOMALIES

Maternal High-Fat Diet Disturbs Uteroplacental Hemodynamics and Increases the Frequency of Stillbirth in a Nonhuman Primate Model of Excess Nutrition

(2011) Antonio E. Frias et al.   ENDOCRINOLOGY

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis

(2011) Julia Monsénégo et al.   JOURNAL OF HEPATOLOGY

LPIN1 rs13412852 Polymorphism in Pediatric Nonalcoholic Fatty Liver Disease

(2011) Luca Valenti et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

Nonalcoholic Fatty Liver Disease

(2011) Krzysztof Lukasz Kopec et al.   NUTRITION IN CLINICAL PRACTICE

The Influence of Maternal Body Mass Index on Infant Adiposity and Hepatic Lipid Content

(2011) Neena Modi et al.   PEDIATRIC RESEARCH

Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates

(2011) Wilmon F. Grant et al.   PLoS One

Intrauterine Growth Retardation and Nonalcoholic Fatty Liver Disease in Children

(2011) Anna Alisi et al.   International Journal of Endocrinology

Genetic polymorphisms in non-alcoholic fatty liver disease in obese Egyptian children

(2011) NehalM El-Koofy et al.   Saudi Journal of Gastroenterology

Maternal high-fat intake predisposes nonalcoholic fatty liver disease in C57BL/6 offspring

(2010) Bianca M. Gregorio et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?

(2010) Leanne Hodson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Obesity Affects the Liver – The Link between Adipocytes and Hepatocytes

(2010) Alexander Wree et al.   DIGESTION

Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: Impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter

(2010) Silvia Sookoian et al.   HEPATOLOGY

Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice

(2010) Kwang Suk Ko et al.   HEPATOLOGY

Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepatitis

(2010) Francisco Caballero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life

(2010) Stefano Romeo et al.   JOURNAL OF HEPATOLOGY

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

(2010) R. Scott Rector et al.   JOURNAL OF HEPATOLOGY

Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis

(2010) Lars P. Bechmann et al.   LIVER INTERNATIONAL

The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome

(2010) Jung Sub Lim et al.   Nature Reviews Gastroenterology & Hepatology

A protective effect of breastfeeding on the progression of non-alcoholic fatty liver disease

(2009) V Nobili et al.   ARCHIVES OF DISEASE IN CHILDHOOD

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial

(2009) D. K. Coletta et al.   DIABETOLOGIA

Abnormal hepatic energy homeostasis in type 2 diabetes

(2009) Julia Szendroedi et al.   HEPATOLOGY

Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression

(2009) Kimberley D. Bruce et al.   HEPATOLOGY

Electron Transport Chain-dependent and -independent Mechanisms of Mitochondrial H2O2Emission during Long-chain Fatty Acid Oxidation

(2009) Erin L. Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

(2009) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

(2009) Zheng Zheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates

(2009) Carrie E. McCurdy et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipotoxicity: Why do saturated fatty acids cause and monounsaturates protect against it?

(2009) Christopher J Nolan et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Electron microscopic findings in non-alcoholic fatty liver disease: Is there a difference between hepatosteatosis and steatohepatitis?

(2009) Emel Ahishali et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis

(2009) Pei-Chun Tsai et al.   LIVER TRANSPLANTATION

Foxo1 integrates insulin signaling with mitochondrial function in the liver

(2009) Zhiyong Cheng et al.   NATURE MEDICINE

Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth–restricted offspring

(2008) Thomas R. Magee et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels

(2008) Maja Stefanovic-Racic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Methionine Metabolism and Liver Disease

(2008) José M. Mato et al.   Annual Review of Nutrition

High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial functionin vivo

(2008) Sudheer K. Mantena et al.   BIOCHEMICAL JOURNAL

Mitochondrial dysfunction: Glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic β-cells

(2008) J LEE et al.   CELLULAR SIGNALLING

Metformin use in children with nonalcoholic fatty liver disease: An open-label, 24-month, observational pilot study

(2008) V NOBILI et al.   CLINICAL THERAPEUTICS

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism

(2008) William L. Holland et al.   ENDOCRINE REVIEWS

Mitochondrial dysfunction in mut methylmalonic acidemia

(2008) Randy J. Chandler et al.   FASEB JOURNAL

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

(2008) Mary E. Rinella et al.   JOURNAL OF LIPID RESEARCH

Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression

(2008) João S. Teodoro et al.   MITOCHONDRION

Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients

(2008) Toshinari Takamura et al.   Obesity