Blood-brain barrier models: Rationale for selection

Harnessing Cerebrospinal Fluid Circulation for Drug Delivery to Brain Tissues

(2021) Ghazal Naseri Kouzehgarani et al.   ADVANCED DRUG DELIVERY REVIEWS

Strategies for delivering therapeutics across the blood–brain barrier

(2021) Georg C. Terstappen et al.   NATURE REVIEWS DRUG DISCOVERY

Guidelines for the experimental design of pharmacokinetic studies with nanomaterials in preclinical animal models

(2020) Michael S. Valic et al.   JOURNAL OF CONTROLLED RELEASE

Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease

(2020) Seong Su Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Models of the blood-brain barrier using iPSC-derived cells

(2020) Louise Delsing et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Preformulation Studies of a Stable PTEN-PDZ Lipopeptide Able to Cross an In Vitro Blood-Brain-Barrier Model as a Potential Therapy for Alzheimer’s Disease

(2020) Aikaterini Lalatsa et al.   PHARMACEUTICAL RESEARCH

Human pluripotent stem cell–derived brain pericyte–like cells induce blood-brain barrier properties

(2019) Matthew J. Stebbins et al.   Science Advances

The amyloid cascade and Alzheimer’s disease therapeutics: theory versus observation

(2019) Rudy J. Castellani et al.   LABORATORY INVESTIGATION

Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression

(2019) Yu Yamazaki et al.   BRAIN

Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody

(2019) Marie Albert et al.   BRAIN

Development of Simplified in Vitro P-Glycoprotein Substrate Assay and in Silico Prediction Models To Evaluate Transport Potential of P-Glycoprotein

(2019) Rikiya Ohashi et al.   MOLECULAR PHARMACEUTICS

Advances in Microfluidic Blood–Brain Barrier (BBB) Models

(2019) Arianna Oddo et al.   TRENDS IN BIOTECHNOLOGY

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

A Simplified, Fully Defined Differentiation Scheme for Producing Blood-Brain Barrier Endothelial Cells from Human iPSCs

(2019) Emma H. Neal et al.   Stem Cell Reports

Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D

(2019) John J. Jamieson et al.   Fluids and Barriers of the CNS

Blood brain barrier permeability prediction using machine learning techniques: An update

(2019) Deeksha Saxena et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Astrocytes: Role and Functions in Brain Pathologies

(2019) Rosalba Siracusa et al.   Frontiers in Pharmacology

The isolation and molecular characterization of cerebral microvessels

(2019) Yun-Kyoung Lee et al.   Nature Protocols

In-vitro blood-brain barrier models for drug screening and permeation studies: an overview

(2019) Sounak Bagchi et al.   Drug Design Development and Therapy

P‐glycoprotein: a role in the export of amyloid‐β in Alzheimer's disease?

(2019) Amanda B. Chai et al.   FEBS Journal

Optimization of osmotic blood-brain barrier opening to enable intravital microscopy studies on drug delivery in mouse cortex

(2019) Chengyan Chu et al.   JOURNAL OF CONTROLLED RELEASE

Impact of aging, Alzheimer's disease and Parkinson's disease on the blood-brain barrier transport of therapeutics

(2018) Yijun Pan et al.   ADVANCED DRUG DELIVERY REVIEWS

Age-dependent changes at the blood-brain barrier. A Comparative structural and functional study in young adult and middle aged rats

(2018) Luca Bors et al.   BRAIN RESEARCH BULLETIN

Localized delivery of therapeutic doxorubicin dose across the canine blood–brain barrier with hyperthermia and temperature sensitive liposomes

(2018) Amy Lee Bredlau et al.   DRUG DELIVERY

Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems

(2018) Houfu Liu et al.   DRUG DISCOVERY TODAY

Reproducibility and replicability of rodent phenotyping in preclinical studies

(2018) Neri Kafkafi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Imaging techniques to study drug transporter function in vivo

(2018) Nicolas Tournier et al.   PHARMACOLOGY & THERAPEUTICS

A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis

(2018) Maria Ribecco-Lutkiewicz et al.   Scientific Reports

Dynamic whole-body PET imaging: principles, potentials and applications

(2018) Arman Rahmim et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In-vitro blood–brain barrier modeling: A review of modern and fast-advancing technologies

(2018) Farzane Sivandzade et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor

(2018) William M. Pardridge et al.   MOLECULAR PHARMACEUTICS

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells

(2018) Xiang Li et al.   Stem Cell Reports

Peptide-functionalized and high drug loaded novel nanoparticles as dual-targeting drug delivery system for modulated and controlled release of paclitaxel to brain glioma

(2018) Primiano Pio Di Mauro et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia

(2018) Sofia D. Santos et al.   JOURNAL OF CONTROLLED RELEASE

Impact of Zn2+ on ABC Transporter Function in Intact Isolated Rat Brain Microvessels, Human Brain Capillary Endothelial Cells, and in Rat in Vivo

(2018) Alexander Zaremba et al.   MOLECULAR PHARMACEUTICS

Oromucosal drug delivery: Trends in in-vitro biopharmaceutical assessment of new chemical entities and formulations

(2018) Martin Brandl et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface

(2017) Duc TT Phan et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Role of Apolipoproteins and α-Synuclein in Parkinson’s Disease

(2017) Fatemeh Nouri Emamzadeh   JOURNAL OF MOLECULAR NEUROSCIENCE

Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis

(2017) Irma Pujol-Autonell et al.   Nanomedicine

Animal models of α-synucleinopathy for Parkinson disease drug development

(2017) James B. Koprich et al.   NATURE REVIEWS NEUROSCIENCE

An altered blood–brain barrier contributes to brain iron accumulation and neuroinflammation in the 6-OHDA rat model of Parkinson’s disease

(2017) Sonia Olmedo-Díaz et al.   NEUROSCIENCE

Zebrafish: A promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier

(2017) Ye Li et al.   PHARMACOLOGICAL RESEARCH

Presenilin-1 mutations and Alzheimer’s disease

(2017) Raymond J. Kelleher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Delivery to the Brain across the Blood-Brain Barrier Using Nanomaterials

(2017) Yung-Hao Tsou et al.   Small

Brain Pericytes As Mediators of Neuroinflammation

(2017) Justin Rustenhoven et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells

(2017) Antje Appelt-Menzel et al.   Stem Cell Reports

An ex Vivo Model for Evaluating Blood–Brain Barrier Permeability, Efflux, and Drug Metabolism

(2016) Karin Hellman et al.   ACS Chemical Neuroscience

Differences in the molecular structure of the blood-brain barrier in the cerebral cortex and white matter: an in silico, in vitro, and ex vivo study

(2016) Ádám Nyúl-Tóth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Internal Structure of 15 nm 3-Helix Micelle Revealed by Small-Angle Neutron Scattering and Coarse-Grained MD Simulation

(2016) JooChuan Ang et al.   BIOMACROMOLECULES

A review of the applications of data mining and machine learning for the prediction of biomedical properties of nanoparticles

(2016) David E. Jones et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Prediction of blood-brain barrier permeability of organic compounds

(2016) A. S. Dyabina et al.   Doklady Biochemistry and Biophysics

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Age-associated physiological and pathological changes at the blood–brain barrier: A review

(2016) Franciska Erdő et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Characterization, in Vivo Evaluation, and Molecular Modeling of Different Propofol–Cyclodextrin Complexes To Assess Their Drug Delivery Potential at the Blood–Brain Barrier Level

(2016) Sergey Shityakov et al.   Journal of Chemical Information and Modeling

Computing the blood brain barrier (BBB) diffusion coefficient: A molecular dynamics approach

(2016) Amir Shamloo et al.   JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

The effect of aging on brain barriers and the consequences for Alzheimer’s disease development

(2016) Nina Gorlé et al.   MAMMALIAN GENOME

Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System

(2016) Yan-Yan Zhang et al.   MOLECULAR PHARMACEUTICS

Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

(2016) Mikko Gynther et al.   MOLECULAR PHARMACEUTICS

In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

(2016) I Loryan et al.   MOLECULAR PSYCHIATRY

Localization and mobility of glucose-coated gold nanoparticles within the brain

(2016) Radka Gromnicova et al.   Nanomedicine

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

(2016) Shira Knafo et al.   NATURE NEUROSCIENCE

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

Astrocytes in physiological aging and Alzheimer’s disease

(2016) J.J. Rodríguez-Arellano et al.   NEUROSCIENCE

Permeability of blood-brain barrier in macaque model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson disease

(2016) Thibaud Thiollier et al.   SYNAPSE

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

(2015) Madison T Gray et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In vivoandex vivoregulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator-activated receptor alpha (Pparα) at the blood-brain barrier

(2015) Md. Tozammel Hoque et al.   JOURNAL OF NEUROCHEMISTRY

3D printed microfluidics for biological applications

(2015) Chee Meng Benjamin Ho et al.   LAB ON A CHIP

A major role for cardiovascular burden in age-related cognitive decline

(2015) Chengxuan Qiu et al.   Nature Reviews Cardiology

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1

(2015) Anita Ramanathan et al.   Frontiers in Aging Neuroscience

Blood–brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment

(2015) Mina Elahy et al.   Immunity & Ageing

A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial cells, Astrocytes and Pericytes

(2015) Louiza Bohn Thomsen et al.   PLoS One

Role of the Blood–Brain Barrier in Multiple Sclerosis

(2014) Genaro Gabriel Ortiz et al.   ARCHIVES OF MEDICAL RESEARCH

Amyloid-beta accumulation, neurogenesis, behavior, and the age of rats.

(2014) Russell M. Church et al.   BEHAVIORAL NEUROSCIENCE

Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

(2014) Joana Bicker et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Blood–brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics

(2014) Danica B Stanimirovic et al.   Expert Opinion on Drug Discovery

Blood—Brain Barrier Breakdown Involves Four Distinct Stages of Vascular Damage in Various Models of Experimental Focal Cerebral Ischemia

(2014) Martin Krueger et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Familial Alzheimer's disease sustained by presenilin 2 mutations: Systematic review of literature and genotype–phenotype correlation

(2014) Marco Canevelli et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Alpha synuclein is transported into and out of the brain by the blood–brain barrier

(2014) Yu-Ting Sui et al.   PEPTIDES

Cell-Culture Models of the Blood–Brain Barrier

(2014) Yarong He et al.   STROKE

Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells

(2014) Stacey Watkins et al.   Nature Communications

AnIn VivoMicrodialysis Study of FLZ Penetration through the Blood-Brain Barrier in Normal and 6-Hydroxydopamine Induced Parkinson’s Disease Model Rats

(2014) Jinfeng Hou et al.   Biomed Research International

A detailed method for preparation of a functional and flexible blood–brain barrier model using porcine brain endothelial cells

(2013) Adjanie Patabendige et al.   BRAIN RESEARCH

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Drug delivery to the brain by focused ultrasound induced blood–brain barrier disruption: Quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy

(2013) Tam Nhan et al.   JOURNAL OF CONTROLLED RELEASE

The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid

(2013) Joost Westerhout et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Brain Uptake of a Fluorescent Vector Targeting the Transferrin Receptor: A Novel Application of in Situ Brain Perfusion

(2013) Wael Alata et al.   MOLECULAR PHARMACEUTICS

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Functional Characterisation of the Maturation of the Blood-Brain Barrier in Larval Zebrafish

(2013) Angeleen Fleming et al.   PLoS One

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

The Role of Pericytes in Blood-Brain Barrier Function and Stroke

(2012) Shuo Liu et al.   CURRENT PHARMACEUTICAL DESIGN

Imaging blood-brain barrier dysfunction in animal disease models

(2012) Andreas Wunder et al.   EPILEPSIA

Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood–brain barrier penetration models

(2012) Éva Hellinger et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Species differences in drug transporters and implications for translating preclinical findings to humans

(2012) Xiaoyan Chu et al.   Expert Opinion on Drug Metabolism & Toxicology

Neurological Diseases in Relation to the Blood–Brain Barrier

(2012) Gary A Rosenberg   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson’s disease

(2012) Valerio Pisani et al.   Journal of Neuroinflammation

IgG Leakage May Contribute to Neuronal Dysfunction in Drug-Refractory Epilepsies With Blood-Brain Barrier Disruption

(2012) Zuzanna Michalak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Enhanced Brain Delivery of the Opioid Peptide DAMGO in Glutathione PEGylated Liposomes: A Microdialysis Study

(2012) Annika Lindqvist et al.   MOLECULAR PHARMACEUTICS

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Aging-Related Changes in Blood-Brain Barrier Integrity and the Effect of Dietary Fat

(2012) R. Takechi et al.   Neurodegenerative Diseases

The neurovascular unit in brain function and disease

(2011) C. Lecrux et al.   Acta Physiologica

Delivery of a Peptide Radiopharmaceutical to Brain with an IgG-Avidin Fusion Protein

(2011) Qing-Hui Zhou et al.   BIOCONJUGATE CHEMISTRY

The role of shear stress in Blood-Brain Barrier endothelial physiology

(2011) Luca Cucullo et al.   BMC NEUROSCIENCE

Animal models in the drug discovery pipeline for Alzheimer's disease

(2011) Debby Van Dam et al.   BRITISH JOURNAL OF PHARMACOLOGY

How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood–brain barrier permeability?

(2011) Alex Avdeef   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

In Vitro Blood–Brain Barrier Models: Current and Perspective Technologies

(2011) Pooja Naik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers

(2011) Donald W. Miller et al.   NEUROUROLOGY AND URODYNAMICS

Fundamentals of microfluidic cell culture in controlled microenvironments

(2010) Edmond W. K. Young et al.   CHEMICAL SOCIETY REVIEWS

Gateways for the intracellular access of nanocarriers: a review of receptor-mediated endocytosis mechanisms and of strategies in receptor targeting

(2010) Noha M Zaki et al.   Expert Opinion on Drug Delivery

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Application of PAMPA-models to predict BBB permeability including efflux ratio, plasma protein binding and physicochemical parameters

(2010) Jurgen Mensch et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Blood–brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE

(2010) Jami Bennett et al.   JOURNAL OF NEUROIMMUNOLOGY

In Vitro Blood-Brain Barrier Models – Latest Advances and Therapeutic Applications in a Chronological Perspective

(2010) M.M.B. Ribeiro et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

(2010) Michael J Bernas et al.   Nature Protocols

Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain

(2010) J. Greenwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Regional differences in capillary density, perfusion rate, and P-glycoprotein activity: A quantitative analysis of regional drug exposure in the brain

(2009) Rong Zhao et al.   BIOCHEMICAL PHARMACOLOGY

Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation

(2009) A. N. Stratman et al.   BLOOD

Reproductive age-related changes in the blood brain barrier: Expression of IgG and tight junction proteins

(2009) Shameena Bake et al.   MICROVASCULAR RESEARCH

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

(2009) Melissa Ouellet et al.   NEUROCHEMISTRY INTERNATIONAL

CNS Delivery Via Adsorptive Transcytosis

(2008) Françoise Hervé et al.   AAPS Journal

CSF as a Surrogate for Assessing CNS Exposure: An Industrial Perspective

(2008) Jiunn Lin   CURRENT DRUG METABOLISM

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY

Decreased blood–brain barrier P-glycoprotein function in the progression of Parkinson’s disease, PSP and MSA

(2008) A. L. Bartels et al.   JOURNAL OF NEURAL TRANSMISSION

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier

(2008) Sandrine Dauchy et al.   JOURNAL OF NEUROCHEMISTRY

Comparison of blood–brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB

(2008) Li Di et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Non-invasive measurement of solute permeability in cerebral microvessels of the rat

(2008) Wei Yuan et al.   MICROVASCULAR RESEARCH

BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood–brain-barrier

(2008) Runa Araya et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL

Subcellular localization of transporters along the rat blood–brain barrier and blood–cerebral-spinal fluid barrier by in vivo biotinylation

(2008) L.M. Roberts et al.   NEUROSCIENCE

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY

Functional and developmental analysis of the blood–brain barrier in zebrafish

(2007) Jae-Yeon Jeong et al.   BRAIN RESEARCH BULLETIN