Animal models in the drug discovery pipeline for Alzheimer's disease

The Canine (Dog) Model of Human Aging and Disease: Dietary, Environmental and Immunotherapy Approaches

(2017) Carl W. Cotman et al.   JOURNAL OF ALZHEIMERS DISEASE

Lithium Treatment Arrests the Development of Neurofibrillary Tangles in Mutant Tau Transgenic Mice with Advanced Neurofibrillary Pathology

(2017) Karelle Leroy et al.   JOURNAL OF ALZHEIMERS DISEASE

The worldwide societal costs of dementia: Estimates for 2009

(2010) Anders Wimo et al.   Alzheimers & Dementia

Diagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively Normal Elderly People

(2010) Geert De Meyer   ARCHIVES OF NEUROLOGY

Selective lesions of the dorsomedial striatum impair serial spatial reversal learning in rats

(2010) Anna Castañé et al.   BEHAVIOURAL BRAIN RESEARCH

Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors

(2010) Dilyara Arslanova et al.   BMC BIOTECHNOLOGY

Neuroprotective role of intermittent fasting in senescence-accelerated mice P8 (SAMP8)

(2010) M. Tajes et al.   EXPERIMENTAL GERONTOLOGY

Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease

(2010) Johanna Magga et al.   Journal of Neuroinflammation

Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease

(2010) T. Ahmed et al.   NEUROSCIENCE

Memantine Improves Cognition and Reduces Alzheimer’s-Like Neuropathology in Transgenic Mice

(2009) Hilda Martinez-Coria et al.   AMERICAN JOURNAL OF PATHOLOGY

Of Mice and Men

(2009) Hugo Geerts   CNS DRUGS

Natural Non-Trasgenic Animal Models for Research in Alzheimers Disease

(2009) Manuel Sarasa et al.   Current Alzheimer Research

Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)☆

(2009) Tauheed Ishrat et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Depletion of Vitamin E Increases Amyloid β Accumulation by Decreasing Its Clearances from Brain and Blood in a Mouse Model of Alzheimer Disease

(2009) Yoichiro Nishida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

(2009) Dominik Paquet et al.   JOURNAL OF CLINICAL INVESTIGATION

Benzo[e]isoindole-1,3-diones as Potential Inhibitors of Glycogen Synthase Kinase-3 (GSK-3). Synthesis, Kinase Inhibitory Activity, Zebrafish Phenotype, and Modeling of Binding Mode

(2009) Haixia Zou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Statins Reduce the Neurofibrillary Tangle Burden in a Mouse Model of Tauopathy

(2009) Moran Boimel et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease

(2009) Ping-Hsiao Shih et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Nitric Oxide Activity and Isoenzyme Expression in the Senescence-Accelerated Mouse P8 Model of Alzheimer's Disease: Effects of Anti-Amyloid Antibody and Antisense Treatments

(2009) A. K. Ali et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling

(2009) Hanbing Zhong et al.   Molecular BioSystems

Cryptotanshinone, an Acetylcholinesterase Inhibitor fromSalvia miltiorrhiza, Ameliorates Scopolamine-Induced Amnesia in Morris Water Maze Task

(2009) Kelvin Wong et al.   PLANTA MEDICA

A Primer for Morpholino Use in Zebrafish

(2009) Brent R. Bill et al.   Zebrafish

Muscarinic receptor 1 agonist activity of novel N-arylthioureas substituted 3-morpholino arecoline derivatives in Alzheimer’s presenile dementia models

(2008) Manish Malviya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ibuprofen modifies cognitive disease progression in an Alzheimer’s mouse model

(2008) D. Van Dam et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease

(2008) Touqeer Ahmed et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mechanisms underlying cognitive enhancement and reversal of cognitive deficits in nonhuman primates by the ampakine CX717

(2008) R. E. Hampson et al.   PSYCHOPHARMACOLOGY

Cerebral Amyloid-Beta Protein Accumulation with Aging in Cotton-Top Tamarins: A Model of Early Alzheimer's Disease?

(2008) Cynthia A. Lemere et al.   REJUVENATION RESEARCH

The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor

(2006) J Meunier et al.   BRITISH JOURNAL OF PHARMACOLOGY