Interest of extracellular vesicles in regards to lipid nanoparticle based systems for intracellular protein delivery

Delivery of Cas9/sgRNA Ribonucleoprotein Complexes via Hydroxystearyl Oligoamino Amides

(2020) Jasmin Kuhn et al.   BIOCONJUGATE CHEMISTRY

Lipid–Saporin Nanoparticles for the Intracellular Delivery of Cytotoxic Protein to Overcome ABC Transporter-Mediated Multidrug Resistance In Vitro and In Vivo

(2020) Guan-Nan Zhang et al.   Cancers

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

(2020) Tuo Wei et al.   Nature Communications

Extracellular vesicles engineered with valency-controlled DNA nanostructures deliver CRISPR/Cas9 system for gene therapy

(2020) Jialang Zhuang et al.   NUCLEIC ACIDS RESEARCH

Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications

(2020) Xiaojuan Zhang et al.   DEVELOPMENTAL CELL

Exosome-based candidates move into the clinic

(2020) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations

(2020) Natalia L. Klyachko et al.   Pharmaceutics

An Inside Job: Applications of Intracellular Single Domain Antibodies

(2020) Eline Soetens et al.   Biomolecules

Exosomes: biogenesis, biologic function and clinical potential

(2019) Yuan Zhang et al.   Cell and Bioscience

Manufacturing and characterization of extracellular vesicles from umbilical cord–derived mesenchymal stromal cells for clinical testing

(2019) Eva Rohde et al.   CYTOTHERAPY

Extracellular Vesicles as Biological Shuttles for Targeted Therapies

(2019) Stefania Raimondo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease

(2019) Matthew J. Haney et al.   Advanced Healthcare Materials

The Intracellular Delivery Of Anti-HPV16 E7 scFvs Through Engineered Extracellular Vesicles Inhibits The Proliferation Of HPV-Infected Cells

(2019) Flavia Ferrantelli et al.   International Journal of Nanomedicine

Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo

(2019) Nikki Heath et al.   Nanomedicine

Post-production modifications of murine mesenchymal stem cell (mMSC) derived extracellular vesicles (EVs) and impact on their cellular interaction

(2019) Sarah Le Saux et al.   BIOMATERIALS

Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy

(2018) Gregor Fuhrmann et al.   ADVANCED MATERIALS

Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins

(2018) Yamin Li et al.   BIOMATERIALS

Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation

(2018) Jing-Hung Wang et al.   MOLECULAR CANCER THERAPEUTICS

High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles

(2018) Andrea Longatti et al.   Nanoscale

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

VSV-G-Enveloped Vesicles for Traceless Delivery of CRISPR-Cas9

(2018) Claudia Montagna et al.   Molecular Therapy-Nucleic Acids

Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts

(2018) Martin P. Stewart et al.   CHEMICAL REVIEWS

SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins

(2018) Haijia Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicles protect glucuronidase model enzymes during freeze-drying

(2018) Julia Frank et al.   Scientific Reports

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

(2018) Wen Liao et al.   Acta Biomaterialia

Exosomes Exploit the Virus Entry Machinery and Pathway To Transmit Alpha Interferon-Induced Antiviral Activity

(2018) Zhenlan Yao et al.   JOURNAL OF VIROLOGY

Gesicle-Mediated Delivery of CRISPR/Cas9 Ribonucleoprotein Complex for Inactivating the HIV Provirus

(2018) Lee A. Campbell et al.   MOLECULAR THERAPY

Delivery of an Artificial Transcription Regulator dCas9-VPR by Extracellular Vesicles for Therapeutic Gene Activation

(2018) Duško Lainšček et al.   ACS Synthetic Biology

Intracellular Delivery of His-Tagged Genome-Editing Proteins Enabled by Nitrilotriacetic Acid-Containing Lipidoid Nanoparticles

(2018) Yamin Li et al.   Advanced Healthcare Materials

Recent advancements in the use of exosomes as drug delivery systems

(2018) Edwin J. Bunggulawa et al.   JOURNAL OF NANOBIOTECHNOLOGY

Cell type-specific and common characteristics of exosomes derived from mouse cell lines: Yield, physicochemical properties, and pharmacokinetics

(2017) Chonlada Charoenviriyakul et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Antitumor HPV E7-specific CTL activity elicited by in vivo engineered exosomes produced through DNA inoculation

(2017) Paola Di Bonito et al.   International Journal of Nanomedicine

Exosomes as novel bio-carriers for gene and drug delivery

(2017) Xin-Chi Jiang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Engineered Exosomes as Vehicles for Biologically Active Proteins

(2017) Ulrich Sterzenbach et al.   MOLECULAR THERAPY

Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery

(2017) Ikuhiko Nakase et al.   Scientific Reports

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

(2017) Stella Cosenza et al.   Scientific Reports

Current progress in innovative engineered antibodies

(2017) William R. Strohl   Protein & Cell

A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents

(2017) Inas Helwa et al.   PLoS One

Improved delivery of Cas9 protein/gRNA complexes using lipofectamine CRISPRMAX

(2016) Xin Yu et al.   BIOTECHNOLOGY LETTERS

Extracellular vesicle-mediated suicide mRNA/protein delivery inhibits glioblastoma tumor growth in vivo

(2016) E P Erkan et al.   CANCER GENE THERAPY

Transfer of the Cystic Fibrosis Transmembrane Conductance Regulator to Human Cystic Fibrosis Cells Mediated by Extracellular Vesicles

(2016) Cyrielle Vituret et al.   HUMAN GENE THERAPY

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

(2016) Wolf Heusermann et al.   JOURNAL OF CELL BIOLOGY

Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery

(2016) Helena M. van Dongen et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

In vitro and ex vivo strategies for intracellular delivery

(2016) Martin P. Stewart et al.   NATURE

Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

(2016) Ming Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

Exosomes Derived fromAkt-Modified Human Umbilical Cord Mesenchymal Stem Cells Improve Cardiac Regeneration and Promote Angiogenesis via Activating Platelet-Derived Growth Factor D

(2016) Jie Ma et al.   Stem Cells Translational Medicine

Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy

(2016) Sarah A. Altınoğlu et al.   Biomaterials Science

Antibodies inside of a cell can change its outside: Can intrabodies provide a new therapeutic paradigm?

(2016) Andrea L.J. Marschall et al.   Computational and Structural Biotechnology Journal

Enhanced Intracellular Protein Transduction by Sequence Defined Tetra-Oleoyl Oligoaminoamides Targeted for Cancer Therapy

(2015) Peng Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Systemically Injectable Enzyme-Loaded Polyion Complex Vesicles as In Vivo Nanoreactors Functioning in Tumors

(2015) Yasutaka Anraku et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Challenges and opportunities for non-antibody scaffold drugs

(2015) Rodrigo Vazquez-Lombardi et al.   DRUG DISCOVERY TODAY

Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

(2015) Tyson Smyth et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

(2015) Gregor Fuhrmann et al.   JOURNAL OF CONTROLLED RELEASE

Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

(2015) Masaki Morishita et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding

(2015) Haijia Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anti-Tumor Effects of Bak-Proteoliposomes against Glioblastoma

(2015) Lavinia Liguori et al.   MOLECULES

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Acute Myocardial Ischemic Injury

(2015) Yuanyuan Zhao et al.   Stem Cells International

Liposome-based Formulation for Intracellular Delivery of Functional Proteins

(2015) Benoît Chatin et al.   Molecular Therapy-Nucleic Acids

Reactive Oxygen Species-Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy

(2014) Ming Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combinatorially Designed Lipid-like Nanoparticles for Intracellular Delivery of Cytotoxic Protein for Cancer Therapy

(2014) Ming Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Promises and Pitfalls of Intracellular Delivery of Proteins

(2014) Ailing Fu et al.   BIOCONJUGATE CHEMISTRY

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delivery of antibodies to the cytosol

(2014) Andrea LJ Marschall et al.   mAbs

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

(2014) John A Zuris et al.   NATURE BIOTECHNOLOGY

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

(2014) Samir Mitragotri et al.   NATURE REVIEWS DRUG DISCOVERY

The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing

(2013) Lukas Stalder et al.   EMBO JOURNAL

Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model

(2013) Suyan Bian et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

(2013) A. Nanbo et al.   JOURNAL OF VIROLOGY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

ALIX and the multivesicular endosome: ALIX in Wonderland

(2013) Christin Bissig et al.   TRENDS IN CELL BIOLOGY

How to get out: ssRNA enveloped viruses and membrane fission

(2013) Winfried Weissenhorn et al.   Current Opinion in Virology

The targeted intracellular delivery of cytochrome C protein to tumors using lipid-apolipoprotein nanoparticles

(2012) Sang Kyoon Kim et al.   BIOMATERIALS

Dynamics of exosome internalization and trafficking

(2012) Tian Tian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Protein Encapsulation in Unilamellar Liposomes: High Encapsulation Efficiency and A Novel Technique to Assess Lipid-Protein Interaction

(2012) Xiaoming Xu et al.   PHARMACEUTICAL RESEARCH

Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: Prediction and prevention

(2011) Janos Szebeni et al.   ADVANCED DRUG DELIVERY REVIEWS

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Tailoring nanocarriers for intracellular protein delivery

(2011) Zhen Gu et al.   CHEMICAL SOCIETY REVIEWS

Protein Transfer Into Human Cells by VSV-G-induced Nanovesicles

(2011) Philippe-Emmanuel Mangeot et al.   MOLECULAR THERAPY

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy

(2010) Tian Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Delivery of Therapeutic Proteins

(2010) Dipak S. Pisal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte Derived Microvesicles Deliver a Cell Death Message via Encapsulated Caspase-1

(2009) Anasuya Sarkar et al.   PLoS One

Progress in developing cationic vectors for non-viral systemic gene therapy against cancer

(2008) Marie Morille et al.   BIOMATERIALS

Liposomes-mediated delivery of pro-apoptotic therapeutic membrane proteins

(2008) Lavinia Liguori et al.   JOURNAL OF CONTROLLED RELEASE

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY