Article
Immunology
Marina de Paula-Silva, Gustavo Henrique Oliveira da Rocha, Milena Fronza Broering, Maria Luiza Queiroz, Silvana Sandri, Rodrigo Azevedo Loiola, Sonia Maria Oliani, Andrea Vieira, Mauro Perretti, Sandra Helena Poliselli Farsky
Summary: Non-responsiveness to anti-TNF-alpha therapies is common in inflammatory bowel disease patients, highlighting the importance of finding biomarkers associated with therapeutic efficacy. Levels of colonic formyl peptide receptor 1 and annexin A1 are correlated with histological recovery in Crohn's disease patients under remission. Infliximab may induce annexin A1 expression and secretion in activated intestinal leukocytes, potentially stimulating epithelial formyl peptide receptors and promoting wound healing in inflammatory bowel disease patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
James D. Sargent, Michael Halenar, Alexander W. Steinberg, Jenny Ozga, Zhiqun Tang, Cassandra A. Stanton, Laura M. Paulin
Summary: This study confirms the association between childhood smoking and the risk of COPD, with childhood smokers having a higher risk of developing COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Cell Biology
Lara Vecchi, Sara Teixeira Soares Mota, Mariana Alves Pereira Zoia, Isabella Castro Martins, Jessica Brito de Souza, Tiago Goss Santos, Adriano de Oliveira Beserra, Victor Piana de Andrade, Luiz Ricardo Goulart, Thaise Goncalves Araujo
Summary: Annexin A1 and interleukin-6 are both overexpressed in breast cancer tissue, indicating a correlation between the two. The activation of the AnxA1/FPR1 autocrine axis plays a crucial role in the IL-6 signaling pathway and has an impact on the tumor microenvironment.
Review
Biochemistry & Molecular Biology
Stanislav Kotlyarov
Summary: Tobacco smoking is a major risk factor for both COPD and ASCVD, and they have common pathogenesis and mutual influence on clinical presentation and prognosis. Smoking-induced systemic inflammation, impaired endothelial function, and oxidative stress play crucial roles in the development and progression of both diseases. Components present in tobacco smoke have adverse effects on various cellular functions, and smoking may also impair the innate immune system and promote oxidative stress in respiratory and vascular systems. This review discusses the importance of smoking in the mechanisms underlying the comorbidity of COPD and ASCVD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Amira A. A. Kamel, Maiada K. K. Hashem, Ebtsam S. S. AbdulKareem, Amal H. H. Ali, Ekram Abdel-Rahman Mahmoud, Alaa S. S. Abd-Elkader, Hebatallah Abdellatif, Alzahra Abdelbadea, Nessren M. M. Abdel-Rady, Mona Gamal E. Al Anany, Marwa A. A. Dahpy
Summary: This study found a strong association between the rs2070600 gene polymorphism and COPD. COPD patients had lower serum levels of sRAGE and higher levels of annexin A1. The GA genotype was most commonly distributed in COPD and was strongly linked to lower serum sRAGE levels. Serum sRAGE and annexin A1 may be considered potential diagnostic tools for COPD.
Article
Respiratory System
Simon D. Pouwels, Valerie R. Wiersma, Immeke E. Fokkema, Marijn Berg, Nick H. T. Ten Hacken, Maarten Van Den Berge, Irene Heijink, Alen Faiz
Summary: Cigarette smoking leads to significant transcriptional changes in lung epithelial cells, and a novel smoking-related inducible eQTL was identified that is associated with altered expression of FPR genes.
Article
Public, Environmental & Occupational Health
Yong Liu, Susan A. Carlson, Kathleen B. Watson, Fang Xu, Kurt J. Greenlund
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death in the United States. The overall COPD prevalence did not change significantly from 2011 to 2021, but there were significant changes in prevalence among different age groups and smoking status. More attention and tailored strategies are needed to reduce COPD prevalence, especially among adults disproportionately affected.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2023)
Article
Medicine, General & Internal
Chiwook Chung, Kyu Na Lee, Kyungdo Han, Dong Wook Shin, Sei Won Lee
Summary: Smoking increases the risk of developing COPD in young individuals, with higher risks for current and heavy smokers. Female smokers are more susceptible to developing COPD than male smokers.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Emanuela Pessolano, Raffaella Belvedere, Nunzia Novizio, Amelia Filippelli, Mauro Perretti, James Whiteford, Antonello Petrella
Summary: This study demonstrated that Mesoglycan promotes cell motility and angiogenesis by acting on the key receptor Syndecan-4. The research revealed that Mesoglycan exerts its pro-angiogenic effects by activating three interconnected molecular axes.
Article
Immunology
Xin Xu, Weiwei Gao, Lei Li, Jiheng Hao, Bin Yang, Tao Wang, Long Li, Xuesong Bai, Fanjian Li, Honglei Ren, Meng Zhang, Liyong Zhang, Jiyue Wang, Dong Wang, Jianning Zhang, Liqun Jiao
Summary: The study suggests that Annexin A1 (ANXA1) may modulate cerebral ischemia-reperfusion (I/R) injury by regulating microglia/macrophage polarization and inflammation. Ac2-26, a peptide of ANXA1, can shift microglia/macrophage polarization towards an anti-inflammatory phenotype, improving outcomes in a mouse model of transient middle cerebral artery occlusion/reperfusion (tMCAO/R). The protective effect is mediated through the FPR2/ALX-dependent AMPK-mTOR pathway and may have potential clinical implications for AIS patients receiving EVT therapy. Plasma ANXA1 levels may serve as a potential biomarker for predicting clinical outcomes.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Simone de Araujo, Victor R. de Melo Costa, Franciele M. Santos, Carla D. Ferreira de Sousa, Thaiane P. Moreira, Matheus R. Goncalves, Franciel B. Felix, Celso M. Queiroz-Junior, Gabriel H. Campolina-Silva, Mauricio Lacerda Nogueira, Michelle A. Sugimoto, Caio S. Bonilha, Mauro Perretti, Danielle G. Souza, Vivian V. Costa, Mauro M. Teixeira
Summary: This study investigated the role of the AnxA1-FPR2/ALX pathway during CHIKV infection. The results showed that genetic deletion of AnxA1 or its receptor enhanced inflammatory responses driven by CHIKV and led to more severe tissue damage. Conversely, treatment with the AnxA1 mimetic peptide reduced inflammation and alleviated pain and edema caused by CHIKV infection.
Article
Biology
Mariantonella Colucci, Azzurra Stefanucci, Adriano Mollica, Anna Maria Aloisi, Francesco Maione, Stefano Pieretti
Summary: Formyl peptide receptor type 2 (FPR2/ALX) plays a crucial role in recognizing pathogen-associated molecular patterns and damage-associated molecular patterns. It is highly expressed in myeloid cells and various other cell types. Research suggests that FPR2/ALX may be involved in pain control in the spinal cord.
Article
Oncology
Jiaqiang Zhang, Kuo-Chin Chiu, Wei-Chun Lin, Szu-Yuan Wu
Summary: This study is the first to estimate the impact of smoking-related COPD in patients with rectal adenocarcinoma undergoing curative resection. Current smokers with COPD had worse survival outcomes than nonsmokers without COPD, and hospitalization for COPD with acute exacerbation within 1 year before diagnosis was an independent risk factor for poor overall survival in these patients.
Article
Cell Biology
Lun Li, Yi Liu, Chin Chiu, Yang Jin, Weixun Zhou, Min Peng, Lung-Chi Chen, Qinghua Sun, Jinming Gao
Summary: The study revealed the important role of CXCR3 in chronic obstructive pulmonary disease, potentially influencing disease progression through MMP9 production. Additionally, genetic analysis showed that a CXCR3 single nucleotide polymorphism is associated with COPD susceptibility and levels of MMP-9 in patients.
Article
Immunology
Zhiquan Zhang, Qing Ma, Ravikanth Velagapudi, William E. Barclay, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Mari L. Shinohara, Niccolo Terrando
Summary: This study developed an orthopedic mouse model to study the impact of surgery on the vulnerable brain and found that neuroinflammation plays a crucial role in perioperative neurocognitive disorders. They also discovered the neuroprotective effects of a biomimetic peptide derived from Annexin-A1, providing a new target for the treatment of these disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Kuang-Den Chen, Ying-Hsien Huang, Mindy Ming-Huey Guo, Ling-Sai Chang, Chi-Hsiang Chu, Li-Feng Bu, Chiao-Lun Chu, Chih-Hung Lee, Shih-Feng Liu, Ho-Chang Kuo
Summary: The study revealed that childhood atopic dermatitis patients have lower global methylation levels compared to control subjects, with differential hypomethylation at the golli-mbp locus being associated with disease severity. This hypomethylation was found to have no significant correlation with IgE levels.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chiung-Yu Lin, Yi-Hsi Wang, Yu -Mu Chen, Kai-Yin Hung, Ya-Chun Chang, Ying-Tang Fang, Ya-Ting Chang, Hung-Cheng Chen, Kuo-Tung Huang, Huang-Chih Chang, Yung-Che Chen, Chin-Chou Wang, Meng-Chih Lin, Wen-Feng Fang
Summary: This study retrospectively enrolled 523 sepsis patients to investigate the predictive value of dynamically monitoring AKI in the ICU for hospital mortality. The results indicated that worsening AKI in the first 3 days of ICU admission may be a sepsis phenotype predictive of higher hospital mortality, potentially due to abnormal inflammatory response.
BIOMEDICAL JOURNAL
(2022)
Article
Infectious Diseases
Chun-Ta Huang, Chia-Hung Chen, Wei-Chih Chen, Yao-Tung Wang, Chih-Cheng Lai, Pin-Kuei Fu, Li-Kuo Kuo, Chin-Ming Chen, Wen-Feng Fang, Chih-Yen Tu, Shih-Chi Ku
Summary: This study compared the clinical efficacy and safety of cefoperazone-sulbactam (CFP-SUL) and piperacillin-tazobactam (PIP-TAZ) in elderly patients with pneumonia. The results showed similar clinical cure rates between CFP-SUL and PIP-TAZ. CFP-SUL was found to be a viable alternative to PIP-TAZ for the treatment of pneumonia in older patients.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Medicine, General & Internal
Ko-Wei Chang, Han-Chung Hu, Li-Chung Chiu, Ming-Cheng Chan, Shinn-Jye Liang, Kuang-Yao Yang, Wei-Chih Chen, Wen-Feng Fang, Yu-Mu Chen, Chau-Chyun Sheu, Wei-An Chang, Hao-Chien Wang, Ying-Chun Chien, Chung-Kan Peng, Chieh-Liang Wu, Kuo-Chin Kao
Summary: This study compared the outcomes of severe influenza pneumonia-related ARDS patients who received prone positioning and ECMO, and found that patients who received prone positioning had better prognosis. The results suggest that patients with influenza-related ARDS may consider prone positioning before ECMO support.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Pediatrics
Mindy Ming-Huey Guo, Kuender D. Yang, Shih-Feng Liu, Ho-Chang Kuo
Summary: The study found that non-pharmaceutical interventions during the COVID-19 pandemic can not only prevent transmissible viral infections, but also reduce the risk of Kawasaki disease.
Article
Respiratory System
Meng-Jer Hsieh, Ning-Hung Chen, Shih-Lung Cheng, Chi-Wei Tao, Yu-Feng Wei, Yao-Kuang Wu, Ming-Cheng Chan, Shih-Feng Liu, Wu-Huei Hsu, Tsung-Ming Yang, Ming-Shian Lin, Ching-Lung Liu, Ping-Hung Kuo, Ying-Huang Tsai
Summary: This study compared the real-world effects of different fixed-dose LABA/LAMA combinations for COPD in Taiwan. The results showed that the annualized rates of moderate-to-severe exacerbation were significantly lower in patients receiving tiotropium/olodaterol or umeclidinium/vilanterol compared to those receiving indacaterol/glycopyrronium. COPD-related symptoms remained stable during the treatment period.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Medicine, General & Internal
Chih-Cheng Lai, Wei-Chih Chen, Li-Kuo Kuo, Yao-Tung Wang, Pin-Kuei Fu, Shih-Chi Ku, Wen-Feng Fang, Chin-Ming Chen, Chih-Yen Tu, Wen-Chien Cheng, Chia-Hung Chen
Summary: The study aimed to compare the clinical efficacy of cefoperazone-sulbactam with piperacillin-tazobactam in treating severe community-acquired pneumonia (SCAP). A total of 815 SCAP patients were enrolled, with 343 receiving cefoperazone-sulbactam and 472 receiving piperacillin-tazobactam. The clinical cure rates and effectiveness were similar between the two treatment groups.
Article
Nutrition & Dietetics
Yi-Hsuan Tsai, Kai-Yin Hung, Wen-Feng Fang
Summary: This study found that maintaining peak glucose levels between 141-220 mg/dL is associated with improved survival rates in sepsis patients with diabetes, while peak glycemic gaps exceeding 146 mg/dL and below -73 mg/dL are linked to poorer survival outcomes. Modified SOFA scores outperform traditional scores in predicting mortality, especially in overweight, underweight, and high nutritional risk patients.
Article
Nutrition & Dietetics
Kai-Yin Hung, Tzu-Hsiu Chen, Ya-Fen Lee, Wen-Feng Fang
Summary: This study aimed to determine the effect of using bio-electrical impedance analysis (BIA) to adjust diet formulas on outcomes of septic patients. 132 septic patients in medical intensive care units were enrolled in a prospective, randomized, double-blind, interventional study. The intervention group, which had access to BIA data, were more likely to achieve caloric and protein intake goals, especially in the low-risk group. The intervention did not significantly affect mortality, but potential benefits were suggested.
Article
Oncology
Huang-Chih Chang, Chin-Chou Wang, Chia-Cheng Tseng, Kuo-Tung Huang, Yu-Mu Chen, Yu-Ping Chang, Chien-Hao Lai, Wen-Feng Fang, Meng-Chih Lin, Hung-Yi Chuang
Summary: This study compared survival outcomes among different subgroups of East Asian patients with advanced NSCLC treated with first-line EGFR-TKIs, and found that afatinib had longer progression-free survival (PFS) compared to erlotinib and gefitinib in certain subgroups.
Article
Cell & Tissue Engineering
Kun-Chen Lin, Wen-Feng Fang, Pei-Hsun Sung, Kuo-Tung Huang, John Y. Chiang, Yi-Ling Chen, Chi-Ruei Huang, Yi-Chen Li, Mel S. Lee, Hon-Kan Yip
Summary: This study examined the efficacy of HUCDMSCs treatment in protecting the rat lung from ARDS injury and the advantages of early and dose-dependent treatment.
CELL TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Meng-Lin Tsai, Chin-Ling Li, Hui-Chuan Chang, Yuh-Chyn Tsai, Ching-Wan Tseng, Shih-Feng Liu
Summary: This study aimed to investigate the relationship between age, dyspnea, airflow obstruction (ADO) and body mass index, airflow obstruction, dyspnea, and exercise (BODE) indexes, pulmonary function, medical costs, and exertional desaturation (ED) in chronic obstructive pulmonary disease (COPD) patients. The results showed that SpO(2) during the 6MWT was an independent factor for ED, and ED was related to BODE and ADO indices, but not related to medical expenses.
MEDICINA-LITHUANIA
(2023)
Article
Immunology
Yu-Ping Chang, Yu-Mu Chen, Ya-Chun Chang, Shih-Feng Liu, Wen-Feng Fang, Tung-Ying Chao, Chao-Chien Wu, Huang-Chih Chang, Meng-Chih Lin, Yung-Che Chen
Summary: This study revealed that clinical markers were associated with acute exacerbations in COPD patients, with white blood cell count, albumin level, and post-BD FEV1 (%) being correlated with year 0 AE, and platelet count, positive asthma history, and pre-BD FEV1 (%) being associated with year 1 AE.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Tsai-Yi Hung, Wen-Lan Wu, Ho-Chang Kuo, Shih-Feng Liu, Chia-Ling Chang, Hui-Chuan Chang, Yuh-Chyn Tsai, Jui-Fang Liu
Summary: This study found that abdominal weight training (AWT) intervention can significantly improve lung function, respiratory muscle strength, and cough ability in patients with prolonged mechanical ventilation (PMV). Additionally, the use of a cough machine (CM) can further improve expiratory muscle strength and cough ability in these patients.