Article
Immunology
Chengpei Ni, Song Gao, Xudong Li, Yuling Zheng, Hua Jiang, Peng Liu, Qingyu Lv, Wenhua Huang, Qian Li, Yuhao Ren, Zhiqiang Mi, Decong Kong, Yongqiang Jiang
Summary: This study explores the role of Fpr2 in the development of streptococcal toxic shock-like syndrome (STSLS) caused by Streptococcus suis (S. suis). It is found that Fpr2 impairs neutrophil recruitment during STSLS, and interfering with neutrophil recruitment could potentially be used as a new treatment for this infectious disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Wei-Dan Luo, Yu-Ping Wang, Jun Lv, Yong Liu, Yuan-Qing Qu, Xiong-Fei Xu, Li-Jun Yang, Zi-Cong Lin, Lin-Na Wang, Rui-Hong Chen, Jiu-Jie Yang, Ya-Ling Zeng, Rui-Long Zhang, Bai-Xiong Huang, Xiao-Yun Yun, Xuan-Ying Wang, Lin-Lin Song, Jian-Hui Wu, Xing-Xia Wang, Xi Chen, Wei Zhang, Hui-Miao Wang, Li-Qun Qu, Meng-Han Liu, Liang Liu, Betty Yuen Kwan Law, Vincent Kam Wai Wong
Summary: The relationship between aging, DNA fragments, and the pathogenesis of rheumatoid arthritis (RA) is not well understood. In this study, it is found that the accumulation of DNA fragments, regulated by the exonuclease TREX1, increases with age and promotes abnormal immune activation. TREX1 overexpression suppresses synovial inflammation in rats, while its deletion leads to higher levels of circulating free DNA and more severe symptoms. These findings indicate that DNA fragments act as inflammatory mediators and TREX1 plays a role in regulating cellular immunity.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Takayuki Marutani, Kodai Nishino, Tomoyuki Miyaji, Keisuke Kamada, Koji Ohura, Yoshiaki Kiso, Hidehito Mukai
Summary: Mitocryptides are a novel family of endogenous neutrophil-activating peptides derived from various mitochondrial proteins. MCT-2, one of these peptides, specifically activates FPR2 and its minimum active structure is a N-terminal heptapeptide. The degradation of MCT-2 in serum generates MCT-2(1-4), which can activate FPR1 and promote delayed immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ya Zhu, Xiaowen Lin, Xin Zong, Shuo Han, Mu Wang, Yuxuan Su, Limin Ma, Xiaojing Chu, Cuiying Yi, Qiang Zhao, Beili Wu
Summary: The involvement of FPR2 in Alzheimer's disease has been revealed. Structures of FPR2 bound to Aβ(42), humanin, or formyl peptides provide insights into Aβ(42) neurotoxicity, humanin neuroprotection, and FPR ligand selectivity.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Marco Lebtig, Jasmin Scheurer, Marie Muenkel, Janna Becker, Effie Bastounis, Andreas Peschel, Dorothee Kretschmer
Summary: Keratinocytes play an important role in protecting the skin barrier by producing inflammatory modulators. Activation of the FPR2 receptor in keratinocytes promotes inflammation and cell proliferation, which is necessary for eliminating bacteria like Staphylococcus aureus from the skin.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jose Luis Rodriguez-Fernandez, Olga Criado-Garcia
Summary: Chemoattraction is the migration of cells towards a chemical gradient, controlled by chemoattractant receptors. Directional sensing and actin-based motility are the two basic activities involved in chemoattraction, and recent research suggests that they can be independently regulated.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Thomas P. Smith, Shorok Mombrikotb, Emma Ransome, Dimitrios-Georgios Kontopoulos, Samraat Pawar, Thomas Bell
Summary: The response of complex microbial communities to climatic fluctuations is still not well understood. This study investigated how bacterial communities in soil can respond to changes in environmental temperature through a combination of phenotypic plasticity and species sorting. The results showed that distinct communities with different phylogenetic and functional characteristics emerged at different temperatures, with K-strategist taxa favored under cooler conditions and r-strategist taxa favored under warmer conditions. The study also found that the dynamic emergence of distinct communities across a wide range of temperatures is driven by the resuscitation of latent functional diversity.
Article
Agriculture, Multidisciplinary
Deepak Kumar Tripathi, Nupur Nagar, Viney Kumar, Nidhi Joshi, Partha Roy, Krishna Mohan Poluri
Summary: In this study, the inhibitory potential of four major catechins (EC/EGC/ECG/EGCG) against CCL2-regulated monocyte/macrophage recruitment was assessed. Catechins with the gallate moiety (ECG/EGCG) specifically attenuated CCL2-induced macrophage migration by binding to a pocket on CCL2. The molecular specificity/stability of CCL2-catechin complexes was regulated by multiple factors, including stereospecificity, hydroxyl groups, carbonyl group positioning, and galloylation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Immunology
Zeyu Sun, Wenhua Huang, Yuling Zheng, Peng Liu, Wenbo Yang, Zinan Guo, Decong Kong, Qingyu Lv, Xinyu Zhou, Zongmin Du, Hua Jiang, Yongqiang Jiang
Summary: The research discovered that mice without the Fpr2 receptor were highly susceptible to GBS infections, showing decreased chemotaxis of neutrophils, decreased bactericidal ability of neutrophils, and high mortality.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Environmental
Fubo Yu, Xiangang Hu
Summary: This paper discusses the potential of machine learning in evaluating the ecological risks of microplastics and highlights the need for standardized protocols for microplastic collection and testing. It suggests referencing methods and theories from research on other particle pollutants and emphasizes the improvement of causality and interpretability in machine learning studies of microplastic risks.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biology
Vivian Vasconcelos Costa, Michelle A. Sugimoto, Josy Hubner, Caio S. Bonilha, Celso Martins Queiroz-Junior, Marcela Helena Goncalves-Pereira, Jianmin Chen, Thomas Gobbetti, Gisele Olinto Libanio Rodrigues, Jordana L. Bambirra, Ingredy B. Passos, Carla Elizabeth Machado Lopes, Thaiane P. Moreira, Kennedy Bonjour, Rossana C. N. Melo, Milton A. P. Oliveira, Marcus Vinicius M. Andrade, Lirlandia Pires Sousa, Danielle Gloria Souza, Helton da Costa Santiago, Mauro Perretti, Mauro Martins Teixeira
Summary: This study suggests that altered levels of Annexin A1, a pro-resolving mediator, play a pathological role in dengue infection, and FPR2/ALX agonists may be a therapeutic target for dengue disease.
Article
Dentistry, Oral Surgery & Medicine
Lauren A. Gordon, Steven F. Miller, Jennifer Caplin, Maria Therese Galang-Boquiren, Sahar Alrayyes, Christina L. Nicholas
Summary: The study did not find a clear relationship between childhood obesity and facial shape, but did find larger facial skeletal sizes in high BMI children, suggesting that childhood obesity may lead to accelerated facial growth.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Cecilia Bussolari, Diego Palumbo, Evgeni Fominsky, Pasquale Nardelli, Rebecca De Lorenzo, Giordano Vitali, Francesco De Cobelli, Patrizia Rovere-Querini, Anna Mara Scandroglio
Summary: The study administered nintedanib through compassionate use to three patients with COVID-19 pneumonia requiring ECMO support and found that the treatment led to rapid improvement in respiratory function and systemic inflammation, resulting in the withdrawal of ECMO support. Nintedanib was well-tolerated by the patients and may have a promising role in modulating lung inflammation and remodeling to promote lung repair in severe COVID-19 cases with delayed respiratory function recovery.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sang Yeon Kim, Jin-Mo Kim, Son Ro Lee, Hyun-Jin Kim, Jae Hee Lee, Ho Lim Choi, Yoon-Jin Lee, Yun-Sil Lee, Jaeho Cho
Summary: Lung inflammation and fibrosis caused by radiotherapy can be attenuated by inducing efferocytosis and enhancing FPR2 expression through the injection of apoptotic cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
BeumJin Park, Seok-Jae Heo, Yong Joon Lee, Mi-Kyoung Seo, Jiyun Hong, Eui-Cheol Shin, Inkyung Jung, Sangwoo Kim
Summary: CD8(+) T cells can recognize and kill early tumor cells, with the efficiency influenced by the coverage of HLA-I tumor antigens. Tumors with HLA-I homozygosity show earlier onset. The association may depend on the tumor type and driver mutation specificity. Testing on an independent dataset confirmed the acceleration of tumor onset in a specific type of tumor with HLA-I heterozygosity.
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)
