Cell-Surface Receptors Transactivation Mediated by G Protein-Coupled Receptors

ROS signalling between endothelial cells and cardiac cells

(2014) M. Zhang et al.   CARDIOVASCULAR RESEARCH

Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways

(2014) Maren Kleine-Brueggeney et al.   CELLULAR SIGNALLING

Regulation of Receptor Tyrosine Kinase Ligand Processing

(2014) C. Adrain et al.   Cold Spring Harbor Perspectives in Biology

TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR

(2013) James Yoo et al.   BMC GASTROENTEROLOGY

c-Src-dependent transactivation of PDGFR contributes to TNF-α-induced MMP-9 expression and functional impairment in osteoblasts

(2013) Chia-Lan Tsai et al.   BONE

A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer

(2013) Alanna M. Gilmour et al.   CELLULAR SIGNALLING

Neu1 sialidase and matrix metalloproteinase-9 cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 and -9 activation, cellular signaling and pro-inflammatory responses

(2013) Samar Abdulkhalek et al.   CELLULAR SIGNALLING

Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches

(2013) Amee J. George et al.   FEBS Journal

WKYMVm-induced cross-talk between FPR2 and HGF receptor in human prostate epithelial cell line PNT1A

(2013) Fabio Cattaneo et al.   FEBS LETTERS

Distinct Signaling Cascades Elicited by Different Formyl Peptide Receptor 2 (FPR2) Agonists

(2013) Fabio Cattaneo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Thrombin-mediated Proteoglycan Synthesis Utilizes Both Protein-tyrosine Kinase and Serine/Threonine Kinase Receptor Transactivation in Vascular Smooth Muscle Cells

(2013) Micah L. Burch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes

(2013) Chun-Yin Huang et al.   MEDIATORS OF INFLAMMATION

A Reactive Oxygen Species-Mediated, Self-Perpetuating Loop Persistently Activates Platelet-Derived Growth Factor Receptor  

(2013) H. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

β-Arrestin-Selective G Protein-Coupled Receptor Agonists Engender Unique Biological Efficacyin Vivo

(2013) Diane Gesty-Palmer et al.   MOLECULAR ENDOCRINOLOGY

Reactive Oxygen Species Are Required for 5-HT-Induced Transactivation of Neuronal Platelet-Derived Growth Factor and TrkB Receptors, but Not for ERK1/2 Activation

(2013) Jeff S. Kruk et al.   PLoS One

Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways

(2013) M. Dang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine-1-phosphate-induced Flk-1 transactivation stimulates mouse embryonic stem cell proliferation through S1P1/S1P3-dependent β-arrestin/c-Src pathways

(2013) Jung Min Ryu et al.   Stem Cell Research

G-protein coupled receptor agonists mediate Neu1 sialidase and matrix metalloproteinase-9 cross-talk to induce transactivation of TOLL-like receptors and cellular signaling

(2012) Samar Abdulkhalek et al.   CELLULAR SIGNALLING

5-HT1A receptors transactivate the platelet-derived growth factor receptor type beta in neuronal cells

(2012) Jeff S. Kruk et al.   CELLULAR SIGNALLING

G protein coupled receptor transactivation: Extending the paradigm to include serine/threonine kinase receptors

(2012) Micah L. Burch et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors

(2012) Danielle Kamato et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Angiotensin II Induces Epithelial-to-Mesenchymal Transition in Renal Epithelial Cells through Reactive Oxygen Species/Src/Caveolin-Mediated Activation of an Epidermal Growth Factor Receptor-Extracellular Signal-Regulated Kinase Signaling Pathway

(2012) J. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of Xanthine Oxidase by Allopurinol Prevents Skeletal Muscle Atrophy: Role of p38 MAPKinase and E3 Ubiquitin Ligases

(2012) Frederic Derbre et al.   PLoS One

Engagement of  -arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation

(2012) G. Oligny-Longpre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor

(2012) H. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGFR trans-activation by urotensin II receptor is mediated by β-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy

(2011) Giovanni Esposito et al.   BASIC RESEARCH IN CARDIOLOGY

Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration

(2011) Dammanahalli K. Jagadeesha et al.   CARDIOVASCULAR RESEARCH

Intracellular signaling cascades triggered by the NK1 fragment of hepatocyte growth factor in human prostate epithelial cell line PNT1A

(2011) Luigi Michele Pavone et al.   CELLULAR SIGNALLING

NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung cancer cells

(2011) Fabio Cattaneo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neu1 Sialidase and Matrix Metalloproteinase-9 Cross-talk Is Essential for Toll-like Receptor Activation and Cellular Signaling

(2011) Samar Abdulkhalek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase C and Protein Kinase C-β 2 Mediate Insulin-Like Growth Factor II-Dependent Sphingosine Kinase 1 Activation

(2011) Hesham M. El-Shewy et al.   MOLECULAR ENDOCRINOLOGY

GPCR/EGFR Cross Talk Is Conserved in Gonadal and Adrenal Steroidogenesis but Is Uniquely Regulated by Matrix Metalloproteinases 2 and 9 in the Ovary

(2011) Liliana Carbajal et al.   MOLECULAR ENDOCRINOLOGY

GPR54 (KISS1R) Transactivates EGFR to Promote Breast Cancer Cell Invasiveness

(2011) Mateusz Zajac et al.   PLoS One

The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example

(2011) Peter J. Little et al.   TheScientificWorldJOURNAL

Receptor tyrosine kinase–G-protein-coupled receptor signalling platforms: out of the shadow?

(2011) Nigel J. Pyne et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Physiology and pathophysiology of matrix metalloproteases

(2010) T. Klein et al.   AMINO ACIDS

Crosstalks between the receptors tyrosine kinase EGFR and TrkA and the GPCR, FPR, in human monocytes are essential for receptors-mediated cell activation

(2010) Nabil El Zein et al.   CELLULAR SIGNALLING

Dissecting how receptor tyrosine kinases modulate G protein-coupled receptor function

(2010) J. Adolfo García-Sáinz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

β-Arrestin 2-mediated heterologous desensitization of IGF-IR by prolonged exposure of SH-SY5Y neuroblastoma cells to a mu opioid agonist

(2010) Antonino Spartà et al.   FEBS LETTERS

NADPH oxidases in cardiovascular disease

(2010) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thrombin Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle Is Mediated by Protease-activated Receptor-1 Transactivation of the Transforming Growth Factor β Type I Receptor

(2010) Micah L. Burch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active Metalloproteases of the A Disintegrin And Metalloprotease (ADAM) Family: Biological Function and Structure

(2010) Theo Klein et al.   JOURNAL OF PROTEOME RESEARCH

Expression and Signaling of Formyl-Peptide Receptors in the Brain

(2010) Fabio Cattaneo et al.   NEUROCHEMICAL RESEARCH

Lysophosphatidic Acid Induces αvβ6 Integrin-Mediated TGF-β Activation via the LPA2 Receptor and the Small G Protein Gαq

(2009) Ming Yan Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

A Differential Role for Endocytosis in Receptor-Mediated Activation of Nox1

(2009) Francis J. Miller et al.   ANTIOXIDANTS & REDOX SIGNALING

Maintenance of adrenergic vascular tone by MMP transactivation of the EGFR requires PI3K and mitochondrial ATP synthesis

(2009) Prabhakara Reddy Nagareddy et al.   CARDIOVASCULAR RESEARCH

Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells

(2009) Yinglin Liu et al.   FASEB JOURNAL

Protein Kinase C-δ Transactivates Platelet-derived Growth Factor Receptor-α in Mechanical Strain-induced Collagenase 3 (Matrix Metalloproteinase-13) Expression by Osteoblast-like Cells

(2009) Chuen-Mao Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Arrestin Mediates β1-Adrenergic Receptor-Epidermal Growth Factor Receptor Interaction and Downstream Signaling

(2009) Douglas G. Tilley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arachidonic acid release by H2O2mediated proliferation of mouse embryonic stem cells: Involvement of Ca2+/PKC and MAPKs-induced EGFR transactivation

(2009) Sang Hun Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mitochondrial Reactive Oxygen Species Mediate GPCR–induced TACE/ADAM17-dependent Transforming Growth Factor-α Shedding

(2009) Timothy J. Myers et al.   MOLECULAR BIOLOGY OF THE CELL

Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, αvβ3-integrin, and TGF-β1 in response to ANG II and high glucose

(2008) Souad Belmadani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

FPRL1-mediated induction of superoxide in LL-37-stimulated IMR90 human fibroblast

(2008) Annalisa Iaccio et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

G Protein-Coupled Receptor-Receptor Tyrosine Kinase Receptor Crosstalk: Regulation of Receptor Sensitivity and Roles of Autocrine Feedback Loops and Signal Integration

(2008) J. Garcia-Sainz et al.   Current Signal Transduction Therapy

4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt/NF-κB signaling pathways

(2008) Seung J. Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of the proteolytic disintegrin metalloproteinases, the ‘Sheddases’

(2008) Gillian Murphy   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY