Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy

Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice

(2021) Wenbin Jia et al.   MOLECULAR NEUROBIOLOGY

Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress

(2021) Yifei Wang et al.   Biomedicines

Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons

(2021) Ichiro Kawahata et al.   Biomedicines

Ligand Bound Fatty Acid Binding Protein 7 (FABP7) Drives Melanoma Cell Proliferation Via Modulation of Wnt/β-Catenin Signaling

(2021) Banlanjo Abdulaziz Umaru et al.   PHARMACEUTICAL RESEARCH

Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress

(2021) An Cheng et al.   ACTA PHARMACOLOGICA SINICA

The Role of CaMKII and ERK Signaling in Addiction

(2021) Wenbin Jia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Environmental Enrichment Attenuates Oxidative Stress and Alters Detoxifying Enzymes in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease

(2020) Jung Hwa Seo et al.   Antioxidants

Fatty Acid Binding Protein 5 Mediates Cell Death by Psychosine Exposure through Mitochondrial Macropores Formation in Oligodendrocytes

(2020) An Cheng et al.   Biomedicines

Inhibition of MPTP-induced α-synuclein oligomerization by fatty acid-binding protein 3 ligand in MPTP-treated mice

(2019) Kazuya Matsuo et al.   NEUROPHARMACOLOGY

Parkinson's Disease and Parkinsonism

(2019) Michael T Hayes   AMERICAN JOURNAL OF MEDICINE

The role of fatty acid binding protein 7 in spinal cord astrocytes in a mouse model of experimental autoimmune encephalomyelitis

(2019) Kenyu Kamizato et al.   NEUROSCIENCE

Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons

(2019) Ichiro Kawahata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence

(2019) Daniel E. Vosberg et al.   MOLECULAR PSYCHIATRY

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

(2019) Hiroshi Maekawa et al.   Cell Reports

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

(2019) Cameron S. Field et al.   Cell Metabolism

An Enriched Environment Ameliorates Oxidative Stress and Olfactory Dysfunction in Parkinson’s Disease with α-Synucleinopathy

(2018) Soohyun Wi et al.   CELL TRANSPLANTATION

Subcellular localization of alpha-synuclein aggregates and their interaction with membranes

(2018) Emanuela Colla et al.   Neural Regeneration Research

Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease

(2018) Emily M. Rocha et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

(2018) Iryna Prots et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

The Close Encounter Between Alpha-Synuclein and Mitochondria

(2018) Mattia Vicario et al.   Frontiers in Neuroscience

Adipocyte Fatty Acid-Binding Protein Promotes Palmitate-Induced Mitochondrial Dysfunction and Apoptosis in Macrophages

(2018) Hui Li et al.   Frontiers in Immunology

Lysosomal catch-and-release controls mTORC1

(2018) Aaron M. Hosios et al.   NATURE CELL BIOLOGY

Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization

(2018) An Cheng et al.   BRAIN RESEARCH

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Epidemiology, Prevention, and Assessment of Tardive Dyskinesia and Advances in Treatment

(2017) Christoph U. Correll et al.   JOURNAL OF CLINICAL PSYCHIATRY

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

(2017) Youdong Pan et al.   NATURE

Oxidative metabolism and Ca 2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease

(2017) James Hamilton et al.   NEUROCHEMISTRY INTERNATIONAL

Proteasome impairment by α-synuclein

(2017) Lisa Zondler et al.   PLoS One

Differential interaction between iron and mutant alpha-synuclein causes distinctive Parkinsonian phenotypes in Drosophila

(2016) Zhou-Jing Zhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase

(2016) M. H. R. Ludtmann et al.   JOURNAL OF NEUROSCIENCE

Fatty Acid-Binding Protein 5 at the Blood–Brain Barrier Regulates Endogenous Brain Docosahexaenoic Acid Levels and Cognitive Function

(2016) Yijun Pan et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression

(2016) Anthony A. Grace   NATURE REVIEWS NEUROSCIENCE

Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy

(2016) Yasuhiro Kawamoto et al.   NEUROSCIENCE LETTERS

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Molecular Determinants of α-Synuclein Mutants’ Oligomerization and Membrane Interactions

(2015) Igor F. Tsigelny et al.   ACS Chemical Neuroscience

The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

(2015) Jennifer M. Deger et al.   AGING CELL

Targeting epidermal fatty acid binding protein for treatment of experimental autoimmune encephalomyelitis

(2015) Enyu Rao et al.   BMC IMMUNOLOGY

Familial Parkinson Disease-associated Mutations Alter the Site-specific Microenvironment and Dynamics of α-Synuclein

(2015) Shruti Sahay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease

(2015) Tatiana K. Rostovtseva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies

(2015) Anna Villar-Piqué et al.   JOURNAL OF NEUROCHEMISTRY

Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane

(2015) Carla R. Pacheco et al.   JOURNAL OF NEUROCHEMISTRY

Fatty Acid-Binding Protein 5 Facilitates the Blood–Brain Barrier Transport of Docosahexaenoic Acid

(2015) Yijun Pan et al.   MOLECULAR PHARMACEUTICS

Metabolic functions of FABPs—mechanisms and therapeutic implications

(2015) Gökhan S. Hotamisligil et al.   Nature Reviews Endocrinology

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation

(2015) Dhiman Ghosh et al.   Scientific Reports

The Newly Discovered Parkinson’s Disease Associated Finnish Mutation (A53E) Attenuates α-Synuclein Aggregation and Membrane Binding

(2014) Dhiman Ghosh et al.   BIOCHEMISTRY

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

(2014) Edward Rockenstein et al.   BRAIN

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of  -synuclein, and enhances its secretion and nuclear localization in cells

(2014) M.-B. Fares et al.   HUMAN MOLECULAR GENETICS

FABP3 Protein Promotes α-Synuclein Oligomerization Associated with 1-Methyl-1,2,3,6-tetrahydropiridine-induced Neurotoxicity

(2014) Norifumi Shioda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acid-binding Protein 5 (FABP5) Regulates Cognitive Function Both by Decreasing Anandamide Levels and by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ) in the Brain

(2014) Shuiliang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction

(2014) Eric S. Luth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Plasma Membrane Compartmentalization of D2 Dopamine Receptors

(2013) Meenakshi Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Oligomers Impair Neuronal Microtubule-Kinesin Interplay

(2013) Iryna Prots et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

(2013) Selcuk A. Tanik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deregulation of calcium homeostasis mediates secreted α–synuclein-induced neurotoxicity

(2013) Katerina Melachroinou et al.   NEUROBIOLOGY OF AGING

The mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice

(2013) Lee J. Martin et al.   NEUROBIOLOGY OF AGING

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

(2013) B.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-synuclein pore forming activity upon membrane association

(2012) Laura Tosatto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship

(2012) Maria Xilouri et al.   MOLECULAR NEUROBIOLOGY

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

The N-terminal region of the dopamine D2 receptor, a rhodopsin-like GPCR, regulates correct integration into the plasma membrane and endocytic routes

(2011) DI Cho et al.   BRITISH JOURNAL OF PHARMACOLOGY

The mode of α-synuclein binding to membranes depends on lipid composition and lipid to protein ratio

(2011) Volodymyr V. Shvadchak et al.   FEBS LETTERS

Kinetic measurements give new insights into lipid membrane permeabilization by α-synuclein oligomers

(2011) Martin Stöckl et al.   Molecular BioSystems

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

(2010) Tim Bartels et al.   BIOPHYSICAL JOURNAL

Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseases

(2010) C. E. Teunissen et al.   EUROPEAN JOURNAL OF NEUROLOGY

Fatty acid binding proteins in brain development and disease

(2010) Rong-Zong Liu et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Heart-Type Fatty Acid Binding Protein Regulates Dopamine D2 Receptor Function in Mouse Brain

(2010) N. Shioda et al.   JOURNAL OF NEUROSCIENCE

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism

(2010) Bart D. van Rooijen et al.   PLoS One

Mitochondrial dysfunction in Parkinson's disease

(2009) Konstanze F. Winklhofer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

Cellular localization of epidermal-type and brain-type fatty acid-binding proteins in adult hippocampus and their response to cerebral ischemia

(2009) Dexuan Ma et al.   HIPPOCAMPUS

Expression of fatty acid-binding proteins in adult hippocampal neurogenic niche of postischemic monkeys

(2009) Nadezhda B. Boneva et al.   HIPPOCAMPUS

Complex I Is Rate-limiting for Oxygen Consumption in the Nerve Terminal

(2009) Jayne E. Telford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regional heterogeneity in astrocyte responses following contusive spinal cord injury in mice

(2009) Robin E. White et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Regulation of Th17 Differentiation by Epidermal Fatty Acid-Binding Protein

(2009) B. Li et al.   JOURNAL OF IMMUNOLOGY

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

(2009) Yaping Chu et al.   NEUROBIOLOGY OF DISEASE

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

The Emerging Functions and Mechanisms of Mammalian Fatty Acid–Binding Proteins

(2008) Judith Storch et al.   Annual Review of Nutrition

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

(2008) Nelson B. Cole et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions

(2008) Melinda A. McFarland et al.   MOLECULAR & CELLULAR PROTEOMICS

Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome

(2008) Evangelia Emmanouilidou et al.   NEUROBIOLOGY OF AGING

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

(2008) Shaik Shavali et al.   NEUROSCIENCE LETTERS