Alteration in the Cerebrospinal Fluid Lipidome in Parkinson’s Disease: A Post-Mortem Pilot Study

Potential application of endocannabinoid system agents in neuropsychiatric and neurodegenerative diseases—focusing on FAAH/MAGL inhibitors

(2020) Si-yu Ren et al.   ACTA PHARMACOLOGICA SINICA

Ten Unsolved Questions About Neuroinflammation in Parkinson's Disease

(2020) Etienne C. Hirsch et al.   MOVEMENT DISORDERS

Vesicle trafficking and lipid metabolism in synucleinopathy

(2020) Saranna Fanning et al.   ACTA NEUROPATHOLOGICA

A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α ‐Synuclein Mice

(2020) Silke Nuber et al.   ANNALS OF NEUROLOGY

Glycosphingolipids and neuroinflammation in Parkinson’s disease

(2020) Karim Belarbi et al.   Molecular Neurodegeneration

The Role of Lipids in Parkinson’s Disease

(2019) Helena Xicoy et al.   Cells

Astrocytic ceramide as possible indicator of neuroinflammation

(2019) Nienke M. de Wit et al.   Journal of Neuroinflammation

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

(2019) Min Kim et al.   Alzheimers & Dementia

Dysregulated Lipid Metabolism and Its Role in α-Synucleinopathy in Parkinson’s Disease

(2019) Irina Alecu et al.   Frontiers in Neuroscience

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

(2019) Thibaut Imberdis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson’s disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling

(2019) Akio Mori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex-Related Abnormalities in Substantia Nigra Lipids in Parkinson’s Disease

(2018) T. N. Seyfried et al.   ASN Neuro

Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain

(2018) Guang Lin et al.   Cell Metabolism

Effects of phosphatidylcholine membrane fluidity on the conformation and aggregation of N-terminally acetylated α-synuclein

(2018) Emma I. O'Leary et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Augmented frontal cortex diacylglycerol levels in Parkinson’s disease and Lewy Body Disease

(2018) Paul L. Wood et al.   PLoS One

Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients

(2018) Damiana Pieragostino et al.   Scientific Reports

Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease

(2018) Daniel Stoessel et al.   Frontiers in Aging Neuroscience

Reduced glucocerebrosidase activity in monocytes from patients with Parkinson’s disease

(2018) Farzaneh Atashrazm et al.   Scientific Reports

NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson’s disease

(2017) Siyuan Zhang et al.   HUMAN MOLECULAR GENETICS

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

(2017) Sylvia Torres-Odio et al.   Journal of Neuroinflammation

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SMPD1 variants in Chinese Han patients with sporadic Parkinson's disease

(2017) Cheng-yuan Mao et al.   PARKINSONISM & RELATED DISORDERS

Dietary and Endogenous Sphingolipid Metabolism in Chronic Inflammation

(2017) et al.   Nutrients

The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson’s Disease

(2017) Céline Galvagnion   Journal of Parkinsons Disease

High Performance Liquid Chromatography-Mass Spectrometry (LC-MS) Based Quantitative Lipidomics Study of Ganglioside-NANA-3 Plasma to Establish Its Association with Parkinson’s Disease Patients

(2017) Jinzhi Zhang et al.   MEDICAL SCIENCE MONITOR

Elevated GM3 plasma concentration in idiopathic Parkinson’s disease: A lipidomic analysis

(2017) Robin B. Chan et al.   PLoS One

Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS

(2017) H. Blasco et al.   Scientific Reports

LRRK2 deficiency impacts ceramide metabolism in brain

(2016) Ruggero Ferrazza et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease

(2016) Joana Magalhaes et al.   HUMAN MOLECULAR GENETICS

Annotation of the human cerebrospinal fluid lipidome using high resolution mass spectrometry and a dedicated data processing workflow

(2016) Alexandre Seyer et al.   Metabolomics

Membrane Lipids in Presynaptic Function and Disease

(2016) Elsa Lauwers et al.   NEURON

Major apoptotic mechanisms and genes involved in apoptosis

(2016) Yağmur Kiraz et al.   TUMOR BIOLOGY

Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer’s disease subjects

(2015) Paul L. Wood et al.   ACTA NEUROPSYCHIATRICA

Autophagic flux and autophagosome morphogenesis require the participation of sphingolipids

(2015) Chiara Tommasino et al.   APOPTOSIS

Major Alterations of Phosphatidylcholine and Lysophosphotidylcholine Lipids in the Substantia Nigra Using an Early Stage Model of Parkinson’s Disease

(2015) Kyle Farmer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

N-Palmitoylethanolamine and Neuroinflammation: a Novel Therapeutic Strategy of Resolution

(2015) Stephen D. Skaper et al.   MOLECULAR NEUROBIOLOGY

Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer’s disease subjects

(2015) Paul L. Wood et al.   ACTA NEUROPSYCHIATRICA

Lipidomics: Analysis of the Lipid Composition of Cells and Subcellular Organelles by Electrospray Ionization Mass Spectrometry

(2014) Britta Brügger   Annual Review of Biochemistry

1H NMR-based metabolomics study on a goldfish model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

(2014) Zhaoguang Lu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cardiovascular risk factors and the risk of Parkinson’s disease

(2014) M Vikdahl et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Palmitoylethanolamide in CNS health and disease

(2014) Giuseppina Mattace Raso et al.   PHARMACOLOGICAL RESEARCH

Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology

(2013) Emma Assi et al.   Clinical & Developmental Immunology

Rotenone induces reductive stress and triacylglycerol deposition in C2C12 cells

(2013) Quan He et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Membrane Remodeling by α-Synuclein and Effects on Amyloid Formation

(2013) Zhiping Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sterols and oxysterols in immune cell function

(2013) Nathanael J Spann et al.   NATURE IMMUNOLOGY

A rare lysosomal enzyme gene SMPD1 variant (p.R591C) associates with Parkinson's disease

(2013) Jia-Nee Foo et al.   NEUROBIOLOGY OF AGING

Dietary fat intake, pesticide use, and Parkinson's disease

(2013) Freya Kamel et al.   PARKINSONISM & RELATED DISORDERS

Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study

(2013) Michelle M. Mielke et al.   PLoS One

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

(2012) Megan M. Young et al.   JOURNAL OF LIPID RESEARCH

Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism

(2012) Hugo Gonzalo et al.   JOURNAL OF NEUROCHEMISTRY

The link between the GBA gene and parkinsonism

(2012) Ellen Sidransky et al.   LANCET NEUROLOGY

Elevated cerebrospinal fluid sphingomyelin levels in prodromal Alzheimer's disease

(2012) M. Kosicek et al.   NEUROSCIENCE LETTERS

Neuroprotective Activities of Palmitoylethanolamide in an Animal Model of Parkinson's Disease

(2012) Emanuela Esposito et al.   PLoS One

Induction of apoptotic erythrocyte death by rotenone

(2012) Adrian Lupescu et al.   TOXICOLOGY

Lipidomics at the Interface of Structure and Function in Systems Biology

(2011) Richard W. Gross et al.   CHEMISTRY & BIOLOGY

Primary fatty acid amide metabolism: conversion of fatty acids and an ethanolamine in N18TG2and SCP cells

(2011) Emma K. Farrell et al.   JOURNAL OF LIPID RESEARCH

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(2011) Noemi Fabelo et al.   MOLECULAR MEDICINE

Cerebrospinal fluid fatty acids in glucocerebrosidase-associated Parkinson's disease

(2011) Stefan P. Schmid et al.   MOVEMENT DISORDERS

Lipid Pathway Alterations in Parkinson's Disease Primary Visual Cortex

(2011) Danni Cheng et al.   PLoS One

Shaping up the membrane: diacylglycerol coordinates spatial orientation of signaling

(2011) María Almena et al.   TRENDS IN BIOCHEMICAL SCIENCES

Distribution and Functions of Sterols and Sphingolipids

(2011) J. T. Hannich et al.   Cold Spring Harbor Perspectives in Biology

Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease

(2011) Chuong B. Do et al.   PLoS Genetics

A Saccharomyces cerevisiae strain unable to store neutral lipids is tolerant to oxidative stress induced by α-synuclein

(2010) Yves Y. Sere et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phosphatidylcholine Biosynthesis during Neuronal Differentiation and Its Role in Cell Fate Determination

(2010) Hebe Marcucci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Ion Channel Formation by the Parkinson's-Disease-Linked E46K Mutant of α-Synuclein Is Corrected by GM3 but Not by GM1 Gangliosides

(2010) Eric Di Pasquale et al.   JOURNAL OF MOLECULAR BIOLOGY

Liquid Chromatography−Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease

(2010) Jonathan Barr et al.   JOURNAL OF PROTEOME RESEARCH

Lipidomics: coming to grips with lipid diversity

(2010) Andrej Shevchenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sphingolipids in inflammation: pathological implications and potential therapeutic targets

(2009) Graeme F. Nixon   BRITISH JOURNAL OF PHARMACOLOGY

Biosynthesis, degradation and pharmacological importance of the fatty acid amides

(2008) Emma K. Farrell et al.   DRUG DISCOVERY TODAY

Genomewide association study for susceptibility genes contributing to familial Parkinson disease

(2008) Nathan Pankratz et al.   HUMAN GENETICS

Oleoylethanolamide exerts partial and dose-dependent neuroprotection of substantia nigra dopamine neurons

(2008) B. Galan-Rodriguez et al.   NEUROPHARMACOLOGY

α-Synuclein and Polyunsaturated Fatty Acids Promote Clathrin-Mediated Endocytosis and Synaptic Vesicle Recycling

(2008) Tziona Ben Gedalya et al.   TRAFFIC

α-Synuclein Selectively Binds to Anionic Phospholipids Embedded in Liquid-Disordered Domains

(2007) Martin Stöckl et al.   JOURNAL OF MOLECULAR BIOLOGY