Dietary and Endogenous Sphingolipid Metabolism in Chronic Inflammation

Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer

(2017) Toshio Ohnishi et al.   FASEB JOURNAL

Dietary sphingomyelin attenuates hepatic steatosis and adipose tissue inflammation in high-fat-diet-induced obese mice

(2017) Gregory H. Norris et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Selective Absorption of Dietary Sphingoid Bases from the Intestine via Efflux by P-Glycoprotein in Rats

(2017) Aoi FUJII et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Effects of Dietary Plant-origin Glucosylceramide on Colon Cytokine Contents in DMH-treated Mice

(2017) Shinji Yamashita et al.   Journal of Oleo Science

The role of a dairy fraction rich in milk fat globule membrane in the suppression of postprandial inflammatory markers and bone turnover in obese and overweight adults: an exploratory study

(2017) Tara S. Rogers et al.   Nutrition & Metabolism

Dietary sphingolipids: potential for management of dyslipidemia and nonalcoholic fatty liver disease

(2017) Gregory H. Norris et al.   NUTRITION REVIEWS

Sphingolipids Contribute to Human Atherosclerotic Plaque InflammationHighlights

(2016) Andreas Edsfeldt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ

(2016) Jinbiao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Analytical methods in sphingolipidomics: Quantitative and profiling approaches in food analysis

(2016) Núria Canela et al.   JOURNAL OF CHROMATOGRAPHY A

Milk sphingomyelin improves lipid metabolism and alters gut microbiota in high fat diet-fed mice

(2016) Gregory H. Norris et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation

(2016) Carolina V. Messias et al.   PLoS One

Sphingomyelin is sorted at thetransGolgi network into a distinct class of secretory vesicle

(2016) Yongqiang Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases

(2016) Tomomi Narita et al.   Scientific Reports

Sphingosine 1-Phosphate-Induced ICAM-1 Expression via NADPH Oxidase/ROS-Dependent NF-κB Cascade on Human Pulmonary Alveolar Epithelial Cells

(2016) Chih-Chung Lin et al.   Frontiers in Pharmacology

Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study1

(2015) Fredrik Rosqvist et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Role of lipid microdomains in TLR-mediated signalling

(2015) Jean-Marie Ruysschaert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Influence of Hydroxylation, Chain Length, and Chain Unsaturation on Bilayer Properties of Ceramides

(2015) Terhi Maula et al.   BIOPHYSICAL JOURNAL

Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis

(2015) Kate A. Parham et al.   FASEB JOURNAL

LPS-mediated septic shock is augmented in ceramide synthase 2 null mice due to elevated activity of TNFα-converting enzyme

(2015) Mohammad Ali et al.   FEBS LETTERS

Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death

(2015) María José Hernández-Corbacho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acid sphingomyelinase-ceramide system in steatohepatitis: A novel target regulating multiple pathways

(2015) Carmen Garcia-Ruiz et al.   JOURNAL OF HEPATOLOGY

Sources, metabolism, and regulation of circulating sphingosine-1-phosphate

(2015) Monika Książek et al.   JOURNAL OF LIPID RESEARCH

Milk Polar Lipids Affect In Vitro Digestive Lipolysis and Postprandial Lipid Metabolism in Mice

(2015) Manon Lecomte et al.   JOURNAL OF NUTRITION

Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice

(2015) Katsuhito Arai et al.   Journal of Oleo Science

Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high-fat fed mice

(2015) Manon Lecomte et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Egg Phospholipids and Cardiovascular Health

(2015) Christopher Blesso   Nutrients

Selective inhibition of sphingosine kinase-1 protects adipose tissue against LPS-induced inflammatory response in Zucker diabetic fatty rats

(2014) Monica Tous et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis

(2014) Raquel Fucho et al.   JOURNAL OF HEPATOLOGY

Involvement of de novo ceramide synthesis in pro-inflammatory adipokine secretion and adipocyte–macrophage interaction

(2014) Yoji Hamada et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Unraveling the Complex Relationship Triad between Lipids, Obesity, and Inflammation

(2014) Shahida A. Khan et al.   MEDIATORS OF INFLAMMATION

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Pharmacologic Inhibition of Sphingomyelin Synthase (SMS) Activity Reduces Apolipoprotein-B Secretion from Hepatocytes and Attenuates Endotoxin-Mediated Macrophage Inflammation

(2014) Bin Lou et al.   PLoS One

High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists

(2014) Aishah Al-Jarallah et al.   PLoS One

Sphingolipid Metabolism and Interorganellar Transport: Localization of Sphingolipid Enzymes and Lipid Transfer Proteins

(2014) Toshiyuki Yamaji et al.   TRAFFIC

Sphingolipids in colon cancer

(2013) Mónica García-Barros et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Effect of dietary sphingomyelin on absorption and fractional synthetic rate of cholesterol and serum lipid profile in humans

(2013) Vanu R Ramprasath et al.   Lipids in Health and Disease

Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids

(2013) Dhirendra K. Simanshu et al.   NATURE

Dietary Sphingomyelin Lowers Hepatic Lipid Levels and Inhibits Intestinal Cholesterol Absorption in High-Fat-Fed Mice

(2013) Rosanna W. S. Chung et al.   PLoS One

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity

(2013) Greg M. Kowalski et al.   PLoS One

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

(2013) C Rutherford et al.   Cell Death & Disease

Impact of Sphingomyelin Synthase 1 Deficiency on Sphingolipid Metabolism and Atherosclerosis in Mice

(2012) Zhiqiang Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance

(2012) J. Boon et al.   DIABETES

Sphingomyelin synthase 2 over-expression induces expression of aortic inflammatory biomarkers and decreases circulating EPCs in ApoE KO mice

(2012) Ya-Rui Zhao et al.   LIFE SCIENCES

The Sjögren-Larsson Syndrome Gene Encodes a Hexadecenal Dehydrogenase of the Sphingosine 1-Phosphate Degradation Pathway

(2012) Kanae Nakahara et al.   MOLECULAR CELL

Role of ceramides in nonalcoholic fatty liver disease

(2012) Mangesh Pagadala et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages

(2012) E Aflaki et al.   Cell Death & Disease

Role of intestinal inflammation as an early event in obesity and insulin resistance

(2011) Shengli Ding et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Ceramide formation as a target in beta-cell survival and function

(2011) Florian Lang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Weight loss amelioration of non-alcoholic steatohepatitis linked to shifts in hepatic ceramide expression and serum ceramide levels

(2011) Kittichai Promrat et al.   HEPATOLOGY RESEARCH

Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme

(2011) Nadia F. Lamour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-rich milk fat diet provides protection against gastrointestinal leakiness in mice treated with lipopolysaccharide

(2011) D.R. Snow et al.   JOURNAL OF DAIRY SCIENCE

Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: importance of peroxisome proliferator-activated receptor γ expression

(2011) Joseph C. Mazzei et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

The effect of milk polar lipids separated from butter serum on the lipid levels in the liver and the plasma of obese-model mouse (KK-Ay)

(2011) Shiomi Watanabe et al.   Journal of Functional Foods

Sphingolipids in human ileostomy content after meals containing milk sphingomyelin

(2010) Lena Ohlsson et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The effect of dietary phytosphingosine on cholesterol levels and insulin sensitivity in subjects with the metabolic syndrome

(2010) M Snel et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Sphingomyelin induces cathepsin D-mediated apoptosis in intestinal epithelial cells and increases inflammation in DSS colitis

(2010) A. Fischbeck et al.   GUT

Mammalian ceramide synthases

(2010) Michal Levy et al.   IUBMB LIFE

Dietary Sphingolipids Ameliorate Disorders of Lipid Metabolism in Zucker Fatty Rats

(2010) Keita Yunoki et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Studies on the Role of Acid Sphingomyelinase and Ceramide in the Regulation of Tumor Necrosis Factor α (TNFα)-converting Enzyme Activity and TNFα Secretion in Macrophages

(2010) Krasimira A. Rozenova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

(2010) Meryem Bektas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide and Ceramide 1-Phosphate Are Negative Regulators of TNF-  Production Induced by Lipopolysaccharide

(2010) S. Jozefowski et al.   JOURNAL OF IMMUNOLOGY

Protection of Intestinal Occludin Tight Junction Protein by Dietary Gangliosides in Lipopolysaccharide-induced Acute Inflammation

(2010) Eek J Park et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Chronic Inflammation in Obesity and the Metabolic Syndrome

(2010) Rosário Monteiro et al.   MEDIATORS OF INFLAMMATION

Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components

(2010) Harry Martin   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

An update on sphingosine-1-phosphate and other sphingolipid mediators

(2010) Henrik Fyrst et al.   Nature Chemical Biology

Identification of dairy fractions with anti-inflammatory properties in models of acute gout

(2009) N. Dalbeth et al.   ANNALS OF THE RHEUMATIC DISEASES

Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domains

(2009) Philipp Rovina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Potential Mechanisms Involved in Ceramide-induced Apoptosis in Human Colon Cancer HT29 Cells

(2009) Jing WANG et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Macrophage Sphingomyelin Synthase 2 Deficiency Decreases Atherosclerosis in Mice

(2009) Jing Liu et al.   CIRCULATION RESEARCH

Gangliosides Protect Bowel in an Infant Model of Necrotizing Enterocolitis by Suppressing Proinflammatory Signals

(2009) Kareena L Schnabl et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities

(2009) G. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingomyelin Synthase 2 Deficiency Attenuates NFκB Activation

(2008) Tiruneh K. Hailemariam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dietary phospholipid-rich dairy milk extract reduces hepatomegaly, hepatic steatosis and hyperlipidemia in mice fed a high-fat diet

(2008) Elaine Wat et al.   ATHEROSCLEROSIS

Analysis of Sphingolipid Classes and Their Contents in Meals

(2008) Keita YUNOKI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Sphingosine-1-Phosphate Induces an Antiinflammatory Phenotype in Macrophages

(2008) Jeniter E. Hughes et al.   CIRCULATION RESEARCH

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

Mechanism of Mitochondrial Glutathione-Dependent Hepatocellular Susceptibility to TNF Despite NF-κB Activation

(2008) Montserrat Marí et al.   GASTROENTEROLOGY

Dietary Sphingomyelin Alleviates Experimental Inflammatory Bowel Disease in Mice

(2008) Furuya et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Phospholipid, Sphingolipid, and Fatty Acid Compositions of the Milk Fat Globule Membrane are Modified by Diet

(2008) Christelle Lopez et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chylomicrons promote intestinal absorption of lipopolysaccharides

(2008) Sarbani Ghoshal et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Sphingolipids.Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols

(2008) Sarah T. Pruett et al.   JOURNAL OF LIPID RESEARCH

Anti-Inflammatory and Anti-Apoptotic Effects of Fumonisin B1, an Inhibitor of Ceramide Synthase, in a Rodent Model of Splanchnic Ischemia and Reperfusion Injury

(2008) S. Cuzzocrea et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS