Sphingolipids: regulators of crosstalk between apoptosis and autophagy

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

Ceramide-Based Therapeutics for the Treatment of Cancer

(2012) Brian M. Barth et al.   Anti-Cancer Agents in Medicinal Chemistry

Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death

(2012) Ozlem Oral et al.   APOPTOSIS

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Evidence for a link between histone deacetylation and Ca2+homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts

(2012) Katja Ihlefeld et al.   BIOCHEMICAL JOURNAL

Ceramide synthases at the centre of sphingolipid metabolism and biology

(2012) Thomas D. Mullen et al.   BIOCHEMICAL JOURNAL

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth

(2012) Daniela Hartmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy

(2012) Vincenzo Gagliostro et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”

(2012) Makoto Taniguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis

(2012) Megan M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes

(2012) Sarah Brice Russo et al.   JOURNAL OF CLINICAL INVESTIGATION

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Conversation between apoptosis and autophagy: “Is it your turn or mine?”

(2011) Vincenzo Giansanti et al.   APOPTOSIS

FTY720 produces caspase-independent cell death of acute lymphoblastic leukemia cells

(2011) Craig T. Wallington-Beddoe et al.   Autophagy

Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae

(2011) Maki Yamagata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

(2011) Kimberly Romero Rosales et al.   BIOCHEMICAL JOURNAL

Dysregulation of sphingolipid metabolism in cancer

(2011) Lindsay K. Ryland et al.   CANCER BIOLOGY & THERAPY

Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8

(2011) M A Laussmann et al.   CELL DEATH AND DIFFERENTIATION

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

(2011) Alfred H. Merrill   CHEMICAL REVIEWS

Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide

(2011) Qing Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy Induced by Deficiency of Sphingosine-1-phosphate Phosphohydrolase 1 Is Switched to Apoptosis by Calpain-mediated Autophagy-related Gene 5 (Atg5) Cleavage

(2011) Sandrine Lépine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dihydroceramide-based Response to Hypoxia

(2011) Cecilia M. Devlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells

(2011) Ting Sun et al.   Journal of Translational Medicine

Human Adenovirus Type 5 Induces Cell Lysis through Autophagy and Autophagy-Triggered Caspase Activity

(2011) H. Jiang et al.   JOURNAL OF VIROLOGY

Inhibition of Protein Degradation Induces Apoptosis through a Microtubule-Associated Protein 1 Light Chain 3-Mediated Activation of Caspase-8 at Intracellular Membranes

(2011) J.-A. Pan et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

(2011) Hyunmi Lee et al.   PLoS One

Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane

(2010) Vidyaramanan Ganesan et al.   APOPTOSIS

Gangliosides induce autophagic cell death in astrocytes

(2010) Jaegyu Hwang et al.   BRITISH JOURNAL OF PHARMACOLOGY

PERK-Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24-Induced Killing of Primary Human Glioblastoma Multiforme Cells

(2010) A. Yacoub et al.   CANCER RESEARCH

Mechanism of Autophagy to Apoptosis Switch Triggered in Prostate Cancer Cells by Antitumor Cytokine Melanoma Differentiation-Associated Gene 7/Interleukin-24

(2010) Sujit K. Bhutia et al.   CANCER RESEARCH

Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation

(2010) A. Puissant et al.   CANCER RESEARCH

Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy

(2010) S Lépine et al.   CELL DEATH AND DIFFERENTIATION

Overview of macroautophagy regulation in mammalian cells

(2010) Maryam Mehrpour et al.   CELL RESEARCH

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Kdo2-Lipid A, a TLR4-specific Agonist, Inducesde NovoSphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy

(2010) Kacee Sims et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis

(2010) Qi Hou et al.   JOURNAL OF LIPID RESEARCH

NF-κB as a common signaling pathway in ganglioside-induced autophagic cell death and activation of astrocytes

(2010) Jaegyu Hwang et al.   JOURNAL OF NEUROIMMUNOLOGY

A Novel Sphingosine Kinase Inhibitor Induces Autophagy in Tumor Cells

(2010) V. Beljanski et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

S1P5 is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells

(2009) Chi-Lun Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response

(2009) Stefka D. Spassieva et al.   BIOCHEMICAL JOURNAL

N-Myristoylation targets dihydroceramide Δ4-desaturase 1 to mitochondria: Partial involvement in the apoptotic effect of myristic acid

(2009) Erwan Beauchamp et al.   BIOCHIMIE

Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells

(2009) Paola Signorelli et al.   CANCER LETTERS

Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation

(2009) S. Colie et al.   CANCER RESEARCH

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

(2009) Can E. Senkal et al.   FASEB JOURNAL

Bax distribution into mitochondrial detergent-resistant microdomains is related to ceramide and cholesterol content in postischemic hearts

(2009) Eduardo Martínez-Abundis et al.   FEBS Journal

Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-de pend ent Manner

(2009) Sujoy Lahiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells

(2009) Evgeny V. Berdyshev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Lysosomal ceramide mediates gemcitabine-induced death of glioma cells

(2009) Claudia A. Dumitru et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

p65/RelA Modulates BECN1 Transcription and Autophagy

(2009) T. Copetti et al.   MOLECULAR AND CELLULAR BIOLOGY

FLIP-mediated autophagy regulation in cell death control

(2009) Jong-Soo Lee et al.   NATURE CELL BIOLOGY

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding

(2008) X. Deng et al.   BLOOD

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

(2008) Dong-Hyung Cho et al.   CANCER LETTERS

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Jiefei Geng et al.   EMBO REPORTS

Ceramide Synthase Inhibition by Fumonisin B1Causes Accumulation of 1-Deoxysphinganine

(2008) Nicholas C. Zitomer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy

(2008) Sophie Pattingre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels

(2008) Leah J. Siskind et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Bioactive sphingolipids: metabolism and function

(2008) Nana Bartke et al.   JOURNAL OF LIPID RESEARCH

N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing

(2008) H. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

(2008) D-D Li et al.   ONCOGENE

Caspases in apoptosis and beyond

(2008) J Li et al.   ONCOGENE

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

(2008) B. D. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide starves cells to death by downregulating nutrient transporter proteins

(2008) G. G. Guenther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA