Article
Cell Biology
Cristina Solana-Manrique, Francisco Jose Sanz, Isabel Torregrosa, Martina Palomino-Schatzlein, Carolina Hernandez-Oliver, Antonio Pineda-Lucena, Nuria Paricio
Summary: The study investigates metabolic disturbances underlying the pathogenesis of Parkinson's disease (PD) using a Drosophila PD model. Through metabolomic analysis, the study finds that metabolic alterations are associated with PD and could potentially serve as therapeutic targets and biomarkers for the disease.
Article
Multidisciplinary Sciences
Manuj Ahuja, Navneet Ammal Kaidery, Otis C. Attucks, Erin McDade, Dmitry M. Hushpulian, Arsen Gaisin, Irina Gaisina, Young Hoon Ahn, Sergey Nikulin, Andrey Poloznikov, Irina Gazaryan, Masayuki Yamamoto, Mitsuyo Matsumoto, Kazuhiko Igarashi, Sudarshana M. Sharma, Bobby Thomas
Summary: Research suggests that genetic deletion or pharmacologic inhibition of Bach1 could be a promising therapeutic approach for Parkinson's disease, offering neuroprotection and reducing oxidative damage and neuroinflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Zijuan Zhang, Hai Li, Yunfang Su, Jinlian Ma, Ye Yuan, Ziyang Yu, Ming Shi, Simai Shao, Zhenqiang Zhang, Christian Holscher
Summary: Research demonstrates that the CCK analogue has neuroprotective effects and improves locomotor function in an acute PD mouse model. It acts by restoring dopaminergic neuron count and synapse number, reducing neuroinflammation and autophagy impairment, and protecting against mitochondrial and ER damage.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Plant Sciences
Junfeng Lei, Lili Shen, Wei Zhang, Fangchao Ma, Jingchen Wang, Tingting Wei, Chengping Xie, Yanli Wang, Qiang Wang
Summary: This study analyzed the metabolic profiling of potato powders from different processing methods and commercial potato powders using H-1 NMR-based metabolomics and machine learning projections. The results showed that hot air-dried potatoes had higher levels of fumarate, glucose, malate, asparagine, choline, GABA, alanine, lactate, threonine, and fatty acids. On the other hand, steam-cooked potatoes had higher levels of phenylalanine, sucrose, proline, citrate, glutamate, and valine. Moreover, the metabolite contents in processed potatoes were higher than those in commercial potato powders, regardless of the drying or cooking methods used. These findings suggest the potential for developing new processing techniques to improve the nutritional value of potatoes.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Ziying Wang, Jinshuai Cui, Dongni Li, Shuzhen Ran, Junqing Huang, Gang Chen
Summary: In this study, a natural compound called morin was found to promote mitophagy and have therapeutic effects on a Parkinson's disease mouse model. Morin acts by activating the AMPK-ULK1 pathway and promoting nuclear translocation of the mitophagy regulator TFEB. This research lays the foundation for the potential use of morin as a clinical drug for Parkinson's disease treatment.
Review
Cell Biology
P. A. Dionisio, J. D. Amaral, C. M. P. Rodrigues
Summary: Parkinson's disease is the second most common neurodegenerative disease globally, typically associated with dopaminergic damage. The main physiological characteristics that make the nigrostriatal circuit more susceptible to mitochondrial dysfunction and oxidative stress are related to several cell death mechanisms, including apoptosis, necrosis, and ferroptosis.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Seulah Lee, Yeon Ji Suh, Yujeong Lee, Seonguk Yang, Dong Geun Hong, Dinakaran Thirumalai, Seung-Cheol Chang, Ki Wung Chung, Young-Suk Jung, Hyung Ryong Moon, Hae Young Chung, Jaewon Lee
Summary: This study investigated the neuroprotective effects of the barbiturate derivative, MHY2699, in a mouse model of Parkinson's disease. The results showed that MHY2699 ameliorated neuroinflammation, inhibited motor dysfunction, and prevented dopaminergic neuronal death in the MPTP-induced mouse model, suggesting its potential as a treatment for PD.
Article
Biochemistry & Molecular Biology
Min Hyung Seo, Sujung Yeo
Summary: Our study investigated the effects of knocking down serping1, a protein associated with smooth muscle contraction, relaxation, and inflammation responses, using serping1 siRNA in 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-induced Parkinson's disease (PD) mice. The results showed that serping1 siRNA decreased serping1 expression and reduced a-syn accumulation in the colon. In addition, the treatment also alleviated a-syn aggregation in the brain, suggesting that serping1 siRNA could potentially alleviate synucleinopathy in the gastrointestinal system and brain regions affected by PD.
Article
Biochemistry & Molecular Biology
Ines Le Mao, Jean Martin-Pernier, Charlyne Bautista, Soizic Lacampagne, Tristan Richard, Gregory Da Costa
Summary: In this study, H-1-NMR metabolomics combined with multivariate analysis was used to investigate the effects of grape maturity, enzyme, and fining treatments on Cabernet Sauvignon wines. The results demonstrated significant impacts of maturity stage, enzymes, and fining agents on a variety of wine metabolites.
Article
Immunology
Na Liu, Liping Bai, Zhipeng Lu, Rou Gu, Dongdong Zhao, Fang Yan, Jie Bai
Summary: TRPV4 is involved in the loss of DA neurons and movement deficits in the substantia nigra of PD mice. This study provides new molecular targets and gene therapy approaches for the treatment of PD in the future.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Min Hyung Seo, Sujung Yeo
Summary: This study explored the link between srpk3 and alpha-syn in muscles in PD, revealing that MPTP intoxication could alter srpk3 expression in muscles, which may be related to changes in alpha-syn expression. These findings could contribute to further understanding of the role of srpk3 in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Chunmei Ma, Ying Liu, Sheng Li, Chanyuan Ma, Jiajia Huang, Shuang Wen, Shuo Yang, Bingwei Wang
Summary: This study revealed that the cGAS-STING pathway is activated during neuroinflammation in MPTP-induced models of Parkinson's disease. The deficiency of cGAS in microglia can alleviate neurotoxicity and inflammation, and the administration of cGAS inhibitors provides neuroprotection. These findings suggest that cGAS may serve as a therapeutic target for Parkinson's disease.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Marika Lanza, Laura Cucinotta, Giovanna Casili, Alessia Filippone, Rossella Basilotta, Anna Paola Capra, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Summary: This study aimed to evaluate the inhibitory effect of Antrodia camphorata (AC) administration on neuroinflammation and oxidative stress in a murine model of Parkinson's disease (PD). The results showed that AC treatment significantly reduced PD-related pathological changes, increased tyrosine hydroxylase expression, reduced alpha-synuclein-positive neurons, restored the myelination process of neurons associated with PD, and attenuated neuroinflammation. Furthermore, AC was able to reduce oxidative stress induced by MPTP injection. This study highlights AC as a potential therapeutic agent for neurodegenerative disorders such as PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Mathilde Bourdon, Pietro Santulli, Fatiha Kateb, Khaled Pocate-Cheriet, Frederic Batteux, Chloe Maignien, Sandrine Chouzenoux, Corinne Bordonne, Louis Marcellin, Gildas Bertho, Charles Chapron
Summary: The study found differences in serum metabolic profiles between patients with adenomyosis and the control group, with specific metabolic profiles observed in different adenomyosis phenotypes. These metabolic changes are associated with processes such as immune activation, cell proliferation, and cell migration.
FERTILITY AND STERILITY
(2021)
Article
Chemistry, Analytical
Yan Lv, Junsong Wang, Dingqiao Xu, Shanting Liao, Pei Li, Qian Zhang, Minghua Yang, Lingyi Kong
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2017)
Article
Biochemical Research Methods
Yue-Xiao Xing, Ming-Hui Li, Liang Tao, Ling-Yu Ruan, Wei Hong, Cheng Chen, Wen-Long Zhao, Han Xu, Jian-Feng Chen, Jun-Song Wang
JOURNAL OF PROTEOME RESEARCH
(2018)
Article
Toxicology
Ling-Yu Ruan, Jun-Ting Fan, Wei Hong, He Zhao, Ming-Hui Li, Lei Jiang, Yong-Hong Fu, Yue-Xiao Xing, Cheng Chen, Jun-Song Wang
TOXICOLOGY LETTERS
(2018)
Article
Toxicology
Wei Hong, Yan Liu, Ming-Hui Li, Yue-Xiao Xing, Ting Chen, Yong-Hong Fu, Lei Jiang, He Zhao, Ai-qun Jia, Jun-Song Wang
TOXICOLOGY RESEARCH
(2018)
Article
Agriculture, Multidisciplinary
Jin-Wei Zhou, Ling-Yu Ruan, Hong-Juan Chen, Huai-Zhi Luo, Huan Jiang, Jun-Song Wang, Ai-Qun Jia
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Correction
Agriculture, Multidisciplinary
Jin-Wei Zhou, Ling-Yu Ruan, Hong-Juan Chen, Huai-Zhi Luo, Huan Jiang, Jun-Song Wang, Ai-Qun Jia
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Cell Biology
Xiao-Wen Yu, Dandan Wei, Ying-Sheng Gao, Hong-Zhi Du, Bo-Yang Yu, Rui-Ming Li, Chang-Min Qian, Xue-Jun Luo, Sheng-Tao Yuan, Jun-Song Wang, Li Sun
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Plant Sciences
Wei Hong, Yu Zhang, Jun Yang, Meng-Yuan Xia, Ji-Feng Luo, Xiao-Nian Li, Yue-Hu Wang, Jun-Song Wang
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Multidisciplinary Sciences
Shan-Ting Liao, Chao Han, Ding-Qiao Xu, Xiao-Wei Fu, Jun-Song Wang, Ling-Yi Kong
NATURE COMMUNICATIONS
(2019)
Article
Plant Sciences
Lingyu Ruan, Wenli Zhao, Buzha-xi Luo, Qi Zheng, Zhichao Liu, Wenya Liu, Daji-deng Ba, Jiage Zhong, Hui Luo, Junsong Wang, Xin Feng
Summary: High-dose HR caused hepatotoxicity and nephrotoxicity in rats, while low-dose ESP showed advantages in reducing toxicity. ESP may induce hepatotoxicity and nephrotoxicity, with HR being the main potential source of nephrotoxicity in ESP.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Yunlin Li, Fengye Wu, Qinyan Wu, Wenya Liu, Guanghui Li, Benxing Yao, Ran Xiao, Yudie Hu, Junsong Wang
Summary: This study presents a low-cost and automatic zebrafish behavior assay apparatus for evaluating the neurobehavioral performance of zebrafish. It utilizes a custom-written behavior analysis algorithm, data processing on a Raspberry Pi, and implements Kalman filter algorithm and ROI region to increase accuracy. The setup was also used to analyze zebrafish behavioral changes under different alcohol concentrations, demonstrating its reliability and accuracy.
Article
Chemistry, Physical
Dong Cui, Xiaohan Shi, Wenya Liu, Keren Zheng, Guangji Yin, Jing Wang, Guantong Han, Yi Wan, Junsong Wang, Wenting Li
Summary: Investigation of the neutralizing behavior of concrete is important for understanding its durability. This study used anthocyanin extracted from February orchid petals to characterize the neutralized regions of cement-based materials. The durability of the indicator was evaluated through comparison and verification using different detection methods. The results showed that the F. orchid indicator was effective in characterizing leaching and sulfate attack.
Article
Chemistry, Analytical
Huihui Meng, Di Xu, Qing Wang, Lin Liu, Wenya Liu, Junsong Wang
Summary: This study suggests that Coptis chinensis water extract (CCWE) has the potential to alleviate the severity and progression of sepsis by modulating the gut microbiome and immune response. CCWE treatment reversed the loss of beneficial bacteria and restored gut microbial balance in sepsis. By increasing energy supply, curbing inflammation, and modulating immune function, CCWE shows promise for sepsis treatment.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Dong Cui, Wenya Liu, Jing Wang, Chunping Gu, Yi Wan, Junsong Wang
Summary: This study investigates the potential of anthocyanins extracted from fresh or stale Orychophragmus violaceus flowers as a substitute for phenolphthalein in tracing carbonation in cementitious materials. The reliability of the anthocyanin indicator in tracing carbonation is verified, and factors affecting the width of the partially carbonated zone in cementitious slurries are studied.
Article
Marine & Freshwater Biology
Ming-Hui Li, Ling-Yu Ruan, Jin-Wei Zhou, Yong-Hong Fu, Lei Jiang, He Zhao, Jun-Song Wang
AQUATIC TOXICOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)