Article
Immunology
Gaelle Tilly, Marion Cadoux, Alexandra Garcia, Jeremy Morille, Sandrine Wiertlewski, Claire Pecqueur, Sophie Brouard, David Laplaud, Nicolas Degauque
Summary: The study found that 12 months of treatment with teriflunomide in patients with RRMS did not affect B cell or CD4 T cell compartments, but had a specific impact on CD8 T cells, including decreased proliferation and reduced production of inflammatory factors. DHODH inhibition also affected the migratory velocity of memory CD8 T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pasquale Picone, Domenico Nuzzo
Summary: In recent years, studies have shown that mitochondrial aberration plays a crucial role in mediating axonal degeneration in Multiple Sclerosis (MS), along with inflammation and demyelination. This has led to the recognition of mitochondria as a potential therapeutic target for MS. Mitochondrial transplantation has emerged as a new approach for treating various diseases, including neurodegenerative diseases. In this hypothesis, the authors propose mitochondrial transplantation as a new, potentially applicable strategy to counteract axonal degeneration in multiple sclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Sebastiano Bucello, Pietro Annovazzi, Paolo Ragonese, Marta Altieri, Valeria Barcella, Roberto Bergamaschi, Alessia Bianchi, Giovanna Borriello, Maria Chiara Buscarinu, Graziella Callari, Marco Capobianco, Fioravante Capone, Paola Cavalla, Rosella Cavarretta, Antonio Cortese, Giovanna De Luca, Massimiliano Di Filippo, Vincenzo Dattola, Roberta Fantozzi, Elisabetta Ferraro, Maria Maddalena Filippi, Claudio Gasperini, Luigi Maria Edoardo Grimaldi, Doriana Landi, Marianna Lo Re, Giulia Mallucci, Paolo Manganotti, Girolama Alessandra Marfia, Massimiliano Mirabella, Paola Perini, Marco Pisa, Sabrina Realmuto, Margherita Russo, Valentina Tomassini, Valentina Liliana Adriana Torri-Clerici, Mauro Zaffaroni, Cristina Zuliani, Sofia Zywicki, Massimo Filippi, Luca Prosperini
Summary: Baseline factors associated with disease activity in patients with RRMS under teriflunomide treatment were identified in this study, with the most important factor being an EDSS > 4.0. The study suggests a place-in-therapy for teriflunomide in naive patients with mild disability level or in those who switched their initial treatment for poor tolerability. Adverse events related with teriflunomide were consistent with literature data, without any new safety concern.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Qi Wu, Qin Wang, Jennifer Yang, Elizabeth A. Mills, Pavani Chilukuri, Aiya Saad, Catherine A. Dowling, Caitlyn Fisher, Brittany Kirch, Yang Mao-Draayer
Summary: The study found that Teriflunomide (TER) can shift the balance of immune cell subsets, promoting a tolerogenic immune response and suppressing the pathogenic immune response in patients with relapsing-remitting multiple sclerosis (RRMS). TER affects regulatory T cells (Tregs) and CD4+ T helper cells, increasing the expression of the immunosuppressive marker CD39 and reducing the expression of the activation marker CXCR3. Additionally, TER has an impact on B cell and NK cell subsets. Therefore, TER plays an important role in immune regulation in RRMS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Steffen Pfeuffer, Laura Kerschke, Tobias Ruck, Leoni Rolfes, Marc Pawlitzki, Philipp Albrecht, Heinz Wiendl, Sven G. Meuth
Summary: This study demonstrated that TRF treatment is associated with favorable outcomes in terms of functional optic nerve recovery following optic neuritis (ON) in early multiple sclerosis. Compared to IFN or GLAT, TRF-treated patients showed higher LCLA and shorter P100 latency, indicating better visual function recovery.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Clinical Neurology
Jussi Lehto, Marjo Nylund, Markus Matilainen, Marcus Sucksdorff, Anna Vuorimaa, Johan Rajander, Saara Wahlroos, Parisa Hariri, Laura Airas
Summary: This study aimed to investigate the activation of brain innate immune cells in teriflunomide-treated patients with relapsing-remitting multiple sclerosis. Imaging techniques including TSPO-PET and MRI were used to assess microglial activity, lesion load, and brain volume. The results showed that treated patients had slightly increased innate immune cell activation in the brain, but no significant changes in lesion-associated smoldering inflammation were observed.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Mehmet Fatih Yetkin, Nur Aleyna Yetkin, Merve Akcakoyunlu, Meral Mirza
Summary: A multiple sclerosis patient treated with teriflunomide did not interrupt treatment during a COVID-19 infection, resulting in a mild course of infection. It may be considered that teriflunomide is a safe disease-modifying treatment option during the pandemic, as observed in this case.
NEUROLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Yaseen Awad-Igbaria, Nadine Ferreira, Ali Keadan, Reem Sakas, Doron Edelman, Alon Shamir, Jean Francous-Soustiel, Eilam Palzur
Summary: Peripheral nerve injury can cause mitochondrial dysfunction and neuronal apoptosis, leading to neuroinflammation and neuromodulation, which contribute to neuropathic pain and motor dysfunction. Hyperbaric oxygen therapy (HBOT) has the potential to treat neuropathic pain and nerve injury, but the cellular and molecular mechanism by which HBOT modulates these conditions through mitochondrial protection is still unclear.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Ludwig Kappos, Robert J. Fox, Michel Burcklen, Mark S. Freedman, Eva K. Havrdova, Brian Hennessy, Reinhard Hohlfeld, Fred Lublin, Xavier Montalban, Carlo Pozzilli, Tatiana Scherz, Daniele D'Ambrosio, Philippe Linscheid, Andrea Vaclavkova, Magdalena Pirozek-Lawniczek, Hilke Kracker, Till Sprenger
Summary: In the OPTIMUM trial, ponesimod showed superiority over teriflunomide in reducing annualized relapse rate, fatigue, MRI activity, brain volume loss, and NEDA status, but not in confirmed disability accumulation. The safety profile was consistent with previous observations and known S1P receptor modulators.
Article
Clinical Neurology
Bitao Bu, Chao Quan, Wenyu Li, Qiuming Zeng, Ziyan Shi, Bo Chen, Lei Zhou, Luya Jin, Hongyu Zhou, Huan Yang
Summary: A retrospective study was conducted to compare the treatment outcomes of teriflunomide and no disease-modifying therapy in Chinese multiple sclerosis patients. The results showed that teriflunomide was associated with a lower relapse rate and less disability accumulation.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Clinical Neurology
L. Lorefice, S. Pilotto, G. Fenu, P. Cimino, D. Firinu, J. Frau, F. Murgia, G. Coghe, E. Cocco
Summary: The study describes the evolution of teriflunomide use in the clinical setting, particularly for naive patients and young women. Predictors of treatment response were investigated, revealing that lower baseline age, lower EDSS score, and lower ARR prior to teriflunomide treatment were associated with achievement of treatment goals.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Review
Immunology
Rongzeng Liu, Shushu Du, Lili Zhao, Sahil Jain, Kritika Sahay, Albert Rizvanov, Vera Lezhnyova, Timur Khaibullin, Ekaterina Martynova, Svetlana Khaiboullina, Manoj Baranwal
Summary: Multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by destruction of the myelin sheath. Immune mechanisms, particularly abnormal lymphocyte activity, play a key role in the pathogenesis of multiple sclerosis. This review summarizes the abnormal function and count of lymphocytes and their contributions to the mechanisms of multiple sclerosis. Additionally, novel therapies aimed at correcting the aberrant function or count of these lymphocytes are discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Emelia Zukowski, Marco Sannella, Jack Donato Rockhold, Gabriella H. Kalantar, Jingting Yu, Sara SantaCruz-Calvo, Madison K. Kuhn, Nasun Hah, Ling Ouyang, Tzu-Wen Wang, Lyanne Murphy, Heather Marszalkowski, Kaleigh Gibney, Micah J. Drummond, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath
Summary: Aging promotes changes in mitochondrial dynamics and function in T cells through the localization of STAT3 to the mitochondria. Limiting the activity of mitoSTAT3 can prevent mitochondrial changes and reduce inflammation. Additionally, the expression of a constitutively phosphorylated form of STAT3 in young adults mimics mitochondrial changes observed in older adults.
Review
Clinical Neurology
Carlo Tornatore, Heinz Wiendl, Alex L. Lublin, Svend S. Geertsen, Jeffrey Chavin, Philippe Truffinet, Amit Bar-Or
Summary: The efficacy and safety of COVID-19 vaccines for MS patients receiving DMTs are still under investigation, with varying results from studies on different DMTs' impact on vaccine response. Guidance currently suggests continuing DMTs during vaccination, with potential adjustments to dosing schedules for improved vaccine response.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Yao Zhang, Hexiang Yin, Dingding Zhang, Yan Xu, Bin Peng, Liying Cui
Summary: This study aimed to explore the efficacy, risk factors, safety, and persistence of teriflunomide in patients with relapsing-remitting multiple sclerosis (RRMS). The results showed that teriflunomide was effective and well-tolerated in treatment-naive RRMS patients. Male patients with high relapse rates and disability before treatment were more likely to experience treatment failure.
JOURNAL OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marvin Korff, Ruben Steigerwald, Elena Bechthold, Dirk Schepmann, Julian A. Schreiber, Sven G. Meuth, Guiscard Seebohm, Bernhard Wuensch
Summary: GluN2B-NMDA receptors play a key role in neurological and neurodegenerative disorders. A new GluN2B-NMDA receptor modulator was developed with promising affinity and pharmacological activity, which could be suitable for human application.
BIOLOGICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Theresia Sarabhai, Lucia Mastrototaro, Sabine Kahl, Gidon J. Boenhof, Marc Jonuscheit, Pavel Bobrov, Hisayuki Katsuyama, Rainer Guthoff, Martin Wolkersdorfer, Christian Herder, Sven G. Meuth, Sven Dreyer, Michael Roden
Summary: This study aimed to examine the effects of hyperbaric oxygen therapy on whole-body glucose metabolism in individuals with type 2 diabetes. The results showed that hyperbaric oxygen therapy decreased fasting blood glucose, improved whole-body insulin sensitivity, and achieved this improvement through decreasing endoplasmic reticulum stress and increasing mitochondrial function.
Article
Cardiac & Cardiovascular Systems
A. G. Bejinariu, M. Schilling, P. Mueller, L. Clasen, S. Gerguri, S. Angendohr, S. Katsianos, J. Schmidt, C. Brinkmeyer, S. G. Meuth, M. Kelm, H. Makimoto
Summary: The total atrial conduction time (TACT) measured by echocardiography can predict the risk of atrial fibrillation (AF) and stroke; adding TACT to the revised Framingham stroke risk profile (rFSRP) significantly improves the prediction of stroke incidence.
Article
Clinical Neurology
Harald Hefter, Dietmar Rosenthal, Alexander Jansen, Raphaela Brauns, Beyza Urer, Hans Bigalke, Hans-Peter Hartung, Sven G. Meuth, John-Ih Lee, Philipp Albrecht, Sara Samadzadeh
Summary: The study found that frequent injections of a complex protein-containing BoNT/A preparation are associated with a significantly higher risk of developing neutralizing antibodies (NABs) compared to injections with a complex protein-free BoNT/A preparation.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Isabel Lutfullin, Maria Eveslage, Stefan Bittner, Gisela Antony, Martina Flaskamp, Felix Luessi, Anke Salmen, Barbara Gisevius, Luisa Klotz, Catharina Korsukewitz, Achim Berthele, Sergiu Groppa, Florian Then Bergh, Brigitte Wildemann, Antonios Bayas, Hayrettin Tumani, Sven G. Meuth, Corinna Trebst, Uwe K. Zettl, Friedemann Paul, Christoph Heesen, Tania Kuempfel, Ralf Gold, Bernhard Hemmer, Frauke Zipp, Heinz Wiendl, Jan D. Luenemann
Summary: Obesity is associated with higher disease severity and poorer outcome in newly diagnosed patients with multiple sclerosis. The presence of obesity at disease onset is linked to higher disability at baseline and at follow-up periods of 2, 4, and 6 years. Obesity management could potentially improve the clinical outcome of multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Pediatrics
Svenja Boekhoff, Maria Eveslage, Julia Beckhaus, Carsten Friedrich, Hermann L. Mueller
Summary: This study found that the degree of disability in craniopharyngioma patients is associated with endocrine, ophthalmological, neuropsychological, and psychosocial factors. A higher degree of disability is linked to lower education, higher body mass index standard deviation, and more severe visual impairment and hypothalamic involvement. Patients with a degree of disability of 100 reported significant limitations in physical and cognitive function, fatigue, and pain, as well as social and occupational contexts.
KLINISCHE PADIATRIE
(2023)
Article
Anesthesiology
Roman M. R. Olivier, Marcel Macke, Jennifer C. Mueller, Lisa Schrader, Maria Eveslage, Marcel Rauer, Carola Wempe, Sven Martens, Alexander Zarbock, Nana-Maria Wagner, Uwe Karst, Deniz Y. Dogan, Andrea U. Steinbicker
Summary: This study tracked the concentration of FCM iron compound before, during, and after cardiac surgery. The results showed that when FCM was used within 48 hours before surgery, most of the iron was stored and only a small amount was lost during the surgery. However, when FCM was used for more than 48 hours, most of the iron was absorbed by the body.
ANESTHESIA AND ANALGESIA
(2023)
Editorial Material
Clinical Neurology
Tilman Schneider-Hohendorf, Heinz Wiendl
Article
Endocrinology & Metabolism
Julia Beckhaus, Carsten Friedrich, Svenja Boekhoff, Gabriele Calaminus, Brigitte Bison, Maria Eveslage, Beate Timmermann, Joerg Flitsch, Hermann L. Mueller
Summary: This cohort study aimed to investigate the clinical presentation and outcome of pediatric patients with craniopharyngiomas (CP) in relation to age at diagnosis. The results showed that children diagnosed with CP before the age of 6 had lower event-free survival but better quality of life. Posterior hypothalamic involvement and hypothalamic lesion were independent risk factors for reduced survival and obesity. Age at diagnosis did not contribute to obesity and reduced quality of life.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Immunology
Michael Heming, Louisa Mueller-Miny, Leoni Rolfes, Andreas Schulte-Mecklenbeck, Tobias J. Brix, Julian Varghese, Marc Pawlitzki, Hermann Pavenstaedt, Martin A. Kriegel, Catharina C. Gross, Heinz Wiendl, Gerd Meyer zu Hoerste
Summary: By studying immune cell compositions using flow cytometry, this study found that an expansion of plasma cells in the blood can be used to distinguish connective tissue diseases (CTD) with neurological manifestations from clinically similar diseases. This provides a new method for the differential diagnosis of CTD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Clinical Neurology
Julia Kraemer, Amit Bar-Or, Timothy J. Turner, Heinz Wiendl
Summary: Bruton tyrosine kinase inhibitors are a promising emerging treatment for multiple sclerosis, as they can target both peripheral immune cells and compartmentalized inflammation. Current therapies for multiple sclerosis are effective in reducing relapses and relapse-associated worsening of disability, but they are less effective in slowing disability accumulation associated with CNS-compartmentalized inflammation. By targeting the B cells and microglia in the CNS, CNS-penetrant BTK inhibitors have the potential to curtail disease progression.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Robert Seifert, Sazan Rasul, Konstantin Seitzer, Maria Eveslage, Laya Rahbar Nikoukar, Katharina Kessel, Michael Schafers, Josef Yu, Alexander R. Haug, Marcus Hacker, Martin Bogemann, Lisa Bodei, Michael J. Morris, Michael S. Hofman, Kambiz Rahbar
Summary: A prognostic risk score was developed using PSMA PET-derived organ-specific total tumor volumes to predict overall survival in patients with prostate cancer.
Article
Health Care Sciences & Services
Kathrin Oelmeier, Ralf Schmitz, Mareike Moellers, Daniela Willy, Marina Sourouni, Kathleen Sondern, Helen Ann Koester, Gunita Apsite, Maria Eveslage, Karen Fischhuber, Michael Storck, Jan Wohlmann, Christian Juhra
Summary: This study aimed to establish a telemedicine network for specialists in maternal-fetal medicine (MFM) to exchange information regarding high-risk pregnancies. The study found that interprofessional video consultations were viewed favorably by providers and led to a reduction in inpatient appointments. This highlights the potential of video consultation in prenatal care.
TELEMEDICINE AND E-HEALTH
(2023)
Meeting Abstract
Dermatology
C. Drerup, M. Eveslage, C. Sunderkoetter, J. Ehrchen
EXPERIMENTAL DERMATOLOGY
(2023)