Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

Published 2016 View Full Article

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Title
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
Authors
Keywords
acute myeloid leukemia, differentiation, HoxA9, high-throughput screen, phenotypic screen, leukemia-initiating cell, dihydroorotate dehydrogenase, brequinar, metabolic inhibitor
Journal
CELL
Volume 167, Issue 1, Pages 171-186.e15
Publisher
Elsevier BV
Online
2016-09-16
DOI
10.1016/j.cell.2016.08.057

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