Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification

Next-generation libraries for robust RNA interference-based genome-wide screens

(2015) Martin Kampmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

(2014) Luke A. Gilbert et al.   CELL

Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps

(2014) Martin Kampmann et al.   Nature Protocols

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Current progress in antiviral strategies

(2014) Zhiyong Lou et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

(2013) Michael C. Bassik et al.   CELL

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

Next-Generation NAMPT Inhibitors Identified by Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens

(2013) Christina J. Matheny et al.   CHEMISTRY & BIOLOGY

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells

(2013) M. Kampmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

(2013) A. M. Robitaille et al.   SCIENCE

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Intervention strategies for emerging viruses: use of antivirals

(2013) Yannick Debing et al.   Current Opinion in Virology

RNA-programmed genome editing in human cells

(2013) Martin Jinek et al.   eLife

Rethinking Molecular Similarity: Comparing Compounds on the Basis of Biological Activity

(2012) Paula M. Petrone et al.   ACS Chemical Biology

Identifying mechanism-of-action targets for drugs and probes

(2012) E. Gregori-Puigjane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of an antioxidant small-molecule with broad-spectrum antiviral activity

(2011) Rekha G. Panchal et al.   ANTIVIRAL RESEARCH

Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

(2011) Q.-Y. Wang et al.   JOURNAL OF VIROLOGY

Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

(2011) A. Bonavia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

(2011) H.-H. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of Dengue Virus Resistance to Brequinar in Cell Culture

(2010) M. Qing et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interplay of Acute and Persistent Infections Caused by Venezuelan Equine Encephalitis Virus Encoding Mutated Capsid Protein

(2010) S. Atasheva et al.   JOURNAL OF VIROLOGY

GSK983: A novel compound with broad-spectrum antiviral activity

(2009) Robert Harvey et al.   ANTIVIRAL RESEARCH

Development of a broad-spectrum antiviral with activity against Ebola virus

(2009) M. Javad Aman et al.   ANTIVIRAL RESEARCH

Tetrahydrocarbazole amides with potent activity against human papillomaviruses

(2009) Kristjan S. Gudmundsson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rapid creation and quantitative monitoring of high coverage shRNA libraries

(2009) Michael C Bassik et al.   NATURE METHODS

Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation

(2009) Marcelo M. Samsa et al.   PLoS Pathogens