Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance

Non-Epithelial Thymic Stromal Cells: Unsung Heroes in Thymus Organogenesis and T Cell Development

(2021) Takeshi Nitta et al.   Frontiers in Immunology

Regulatory T Cell Heterogeneity in the Thymus: Impact on Their Functional Activities

(2021) Jérémy C. Santamaria et al.   Frontiers in Immunology

A cell atlas of human thymic development defines T cell repertoire formation

(2020) Jong-Eun Park et al.   SCIENCE

Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development

(2020) Hong-Xia Wang et al.   Frontiers in Immunology

CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells

(2020) Rebecca F. Rogers et al.   CANCER RESEARCH

RFC2, a direct target of miR-744, modulates the cell cycle and promotes the proliferation of CRC cells

(2020) Tao Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells

(2020) Beth Lucas et al.   Nature Communications

Generation and Regeneration of Thymic Epithelial Cells

(2020) Abdullah S. Alawam et al.   Frontiers in Immunology

Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates

(2020) Marie-Ève Lebel et al.   Nature Communications

OPG Production Matters Where It Happened

(2020) Masayuki Tsukasaki et al.   Cell Reports

Ageing compromises mouse thymus function and remodels epithelial cell differentiation

(2020) Jeanette Baran-Gale et al.   eLife

mTORC2 negatively controls the maturation process of medullary thymic epithelial cells by inhibiting the LTβR/RANK‐NF‐κB axis

(2020) Zhanfeng Liang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells

(2020) Kristen L Wells et al.   eLife

Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs

(2019) Linda Clijsters et al.   MOLECULAR CELL

SIRT6, a Mammalian deacylase with multitasking abilities

(2019) Andrew R Chang et al.   PHYSIOLOGICAL REVIEWS

MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance

(2018) Zhanfeng Liang et al.   Autophagy

Thymic tolerance as a key brake on autoimmunity

(2018) Mickie Cheng et al.   NATURE IMMUNOLOGY

RelB intrinsically regulates the development and function of medullary thymic epithelial cells

(2018) Caiwei Jin et al.   Science China-Life Sciences

CGPS: A machine learning-based approach integrating multiple gene set analysis tools for better prioritization of biologically relevant pathways

(2018) Chen Ai et al.   Journal of Genetics and Genomics

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

(2018) Chamutal Bornstein et al.   NATURE

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

(2018) Corey N. Miller et al.   NATURE

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

(2018) Weiqi Zhang et al.   NATURE

Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells

(2017) Marc Riemann et al.   JOURNAL OF AUTOIMMUNITY

Essential role of CCL21 in establishment of central self-tolerance in T cells

(2017) Mina Kozai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A type 2 cytokine axis for thymus emigration

(2017) Andrea J. White et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Redefining thymus medulla specialization for central tolerance

(2017) Emilie J. Cosway et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Generation of Peptides That Promote Positive Selection in the Thymus

(2017) Kensuke Takada et al.   JOURNAL OF IMMUNOLOGY

Transforming growth factor-β1 induces cell cycle arrest by activating atypical cyclin-dependent kinase 5 through up-regulation of Smad3-dependent p35 expression in human MCF10A mammary epithelial cells

(2016) Seong Ji Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress

(2016) Slavica Tudzarova et al.   CELL CYCLE

SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling

(2016) Hu Wang et al.   Cell Stem Cell

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

(2016) Saulius Žuklys et al.   NATURE IMMUNOLOGY

Tolerance is established in polyclonal CD4+ T cells by distinct mechanisms, according to self-peptide expression patterns

(2016) Deepali Malhotra et al.   NATURE IMMUNOLOGY

Affinity for self antigen selects Treg cells with distinct functional properties

(2016) Lena Wyss et al.   NATURE IMMUNOLOGY

Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown

(2016) Mihaela Pertea et al.   Nature Protocols

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

(2016) Luisa Tasselli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3 + T Cells

(2016) Jennifer E. Cowan et al.   Cell Reports

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

(2015) Anna Chuprin et al.   NATURE IMMUNOLOGY

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

DNA Methylation Status of Key Cell-Cycle Regulators Such as CDKNA2/p16 and CCNA1 Correlates with Treatment Response to Doxorubicin and 5-Fluorouracil in Locally Advanced Breast Tumors

(2014) J. Klajic et al.   CLINICAL CANCER RESEARCH

Population and single-cell genomics reveal theAiredependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

(2014) Stephen N. Sansom et al.   GENOME RESEARCH

Limitation of immune tolerance–inducing thymic epithelial cell development by Spi-B–mediated negative feedback regulation

(2014) Nobuko Akiyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Lymphotoxin Pathway Regulates Aire-Independent Expression of Ectopic Genes and Chemokines in Thymic Stromal Cells

(2014) N. Seach et al.   JOURNAL OF IMMUNOLOGY

Maintenance of Thymic Epithelial Phenotype Requires Extrinsic Signals in Mouse and Zebrafish

(2014) C. Soza-Ried et al.   JOURNAL OF IMMUNOLOGY

PU.1 Opposes IL-7–Dependent Proliferation of Developing B Cells with Involvement of the Direct Target GeneBruton Tyrosine Kinase

(2014) Darah A. Christie et al.   JOURNAL OF IMMUNOLOGY

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

(2014) Mathias Hauri-Hohl et al.   NATURE IMMUNOLOGY

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Thymus and aging: morphological, radiological, and functional overview

(2013) Rita Rezzani et al.   AGE

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function

(2013) B. Liu et al.   DEVELOPMENT

The thymic medulla is required for Foxp3+regulatory but not conventional CD4+thymocyte development

(2013) Jennifer E. Cowan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Helios marks strongly autoreactive CD4+T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB

(2013) Stephen R. Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphatase Wip1 Is Essential for the Maturation and Homeostasis of Medullary Thymic Epithelial Cells in Mice

(2013) L. Sun et al.   JOURNAL OF IMMUNOLOGY

A Broad Range of Self-Reactivity Drives Thymic Regulatory T Cell Selection to Limit Responses to Self

(2012) Hyang-Mi Lee et al.   IMMUNITY

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Changes in primary lymphoid organs with aging

(2012) Ivan K. Chinn et al.   SEMINARS IN IMMUNOLOGY

Thymic epithelial cells: working class heroes for T cell development and repertoire selection

(2012) Graham Anderson et al.   TRENDS IN IMMUNOLOGY

TNF receptor family signaling in the development and functions of medullary thymic epithelial cells

(2012) Taishin Akiyama et al.   Frontiers in Immunology

It’s not all equal: a multiphasic theory of thymic involution

(2011) Danielle Aw et al.   BIOGERONTOLOGY

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

(2011) Eriko Michishita et al.   CELL CYCLE

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

(2011) Bo Yang et al.   CELL CYCLE

Structure and Biochemical Functions of SIRT6

(2011) Patricia W. Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Thymic involution and immune reconstitution

(2009) Heather E. Lynch et al.   TRENDS IN IMMUNOLOGY

Thymus Organogenesis

(2008) Hans-Reimer Rodewald   Annual Review of Immunology

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

(2008) Yu Hikosaka et al.   IMMUNITY

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

(2008) Taishin Akiyama et al.   IMMUNITY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE