mTORC2 negatively controls the maturation process of medullary thymic epithelial cells by inhibiting the LTβR/RANK‐NF‐κB axis

Molecular regulatory networks of thymic epithelial cell differentiation

(2019) Rong Luan et al.   DIFFERENTIATION

MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance

(2018) Zhanfeng Liang et al.   Autophagy

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

(2018) Chamutal Bornstein et al.   NATURE

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

(2018) Corey N. Miller et al.   NATURE

Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells

(2017) Marc Riemann et al.   JOURNAL OF AUTOIMMUNITY

mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development

(2016) Hong-Xia Wang et al.   JOURNAL OF IMMUNOLOGY

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

(2016) Saulius Žuklys et al.   NATURE IMMUNOLOGY

mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination

(2016) Hong-Xia Wang et al.   PLOS BIOLOGY

Osteoprotegerin-Mediated Homeostasis of Rank+Thymic Epithelial Cells Does Not Limit Foxp3+Regulatory T Cell Development

(2015) Nicholas I. McCarthy et al.   JOURNAL OF IMMUNOLOGY

Medullary Thymic Epithelial Stem Cells Maintain a Functional Thymus to Ensure Lifelong Central T Cell Tolerance

(2014) Miho Sekai et al.   IMMUNITY

Limitation of immune tolerance–inducing thymic epithelial cell development by Spi-B–mediated negative feedback regulation

(2014) Nobuko Akiyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

(2014) Mathias Hauri-Hohl et al.   NATURE IMMUNOLOGY

Medullary thymic epithelial cell depletion leads to autoimmune hepatitis

(2013) Anthony J. Bonito et al.   JOURNAL OF CLINICAL INVESTIGATION

The thymic medulla is required for Foxp3+regulatory but not conventional CD4+thymocyte development

(2013) Jennifer E. Cowan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphatase Wip1 Is Essential for the Maturation and Homeostasis of Medullary Thymic Epithelial Cells in Mice

(2013) L. Sun et al.   JOURNAL OF IMMUNOLOGY

Thymic epithelial cell development and differentiation: cellular and molecular regulation

(2013) Lina Sun et al.   Protein & Cell

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

TNF receptor family signaling in the development and functions of medullary thymic epithelial cells

(2012) Taishin Akiyama et al.   Frontiers in Immunology

Lymphotoxin Signals from Positively Selected Thymocytes Regulate the Terminal Differentiation of Medullary Thymic Epithelial Cells

(2010) A. J. White et al.   JOURNAL OF IMMUNOLOGY

CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus

(2009) D. A. Zlotoff et al.   BLOOD

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

(2008) Yu Hikosaka et al.   IMMUNITY

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

(2008) Taishin Akiyama et al.   IMMUNITY