MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance

FOXN1 in thymus organogenesis and development

(2016) Harsh Jayesh Vaidya et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development

(2016) Hong-Xia Wang et al.   JOURNAL OF IMMUNOLOGY

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

(2016) Lianjun Zhang et al.   Cell Reports

mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination

(2016) Hong-Xia Wang et al.   PLOS BIOLOGY

mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors

(2016) Tingting Wu et al.   Scientific Reports

A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications

(2015) Sujuan Guo et al.   Autophagy

TSC1 controls IL-1β expression in macrophages via mTORC1-dependent C/EBPβ pathway

(2015) Tao Yang et al.   Cellular & Molecular Immunology

mTOR signaling in cellular and organismal energetics

(2015) Verena Albert et al.   CURRENT OPINION IN CELL BIOLOGY

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

(2015) Kristen N. Pollizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development

(2015) F. Brunk et al.   JOURNAL OF IMMUNOLOGY

FSP1+ fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells

(2015) Lina Sun et al.   Scientific Reports

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Mammalian Target of Rapamycin Complex 1 Orchestrates Invariant NKT Cell Differentiation and Effector Function

(2014) Lianjun Zhang et al.   JOURNAL OF IMMUNOLOGY

The Inhibitory Effect of IFN-  on Protease HTRA1 Expression in Rheumatoid Arthritis

(2014) Y. Hou et al.   JOURNAL OF IMMUNOLOGY

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

(2014) Mathias Hauri-Hohl et al.   NATURE IMMUNOLOGY

Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function

(2014) J. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

Lipopolysaccharide Increases the Incidence of Collagen-Induced Arthritis in Mice Through Induction of Protease HTRA-1 Expression

(2013) Yuzhu Hou et al.   ARTHRITIS AND RHEUMATISM

Generation of both cortical and Aire+medullary thymic epithelial compartments from CD205+progenitors

(2013) Song Baik et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4+CD25+Foxp3+ regulatory T-cell development in mice

(2013) Hui Chen et al.   FASEB JOURNAL

Thymic epithelial β-catenin is required for adult thymic homeostasis and function

(2013) Chih-Chia Liang et al.   IMMUNOLOGY AND CELL BIOLOGY

The thymic medulla is required for Foxp3+regulatory but not conventional CD4+thymocyte development

(2013) Jennifer E. Cowan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphatase Wip1 Is Essential for the Maturation and Homeostasis of Medullary Thymic Epithelial Cells in Mice

(2013) L. Sun et al.   JOURNAL OF IMMUNOLOGY

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

A novel image-based cytometry method for autophagy detection in living cells

(2012) Leo Li-Ying Chan et al.   Autophagy

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development

(2012) Konstantina Alexandropoulos et al.   IMMUNOLOGIC RESEARCH

TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice

(2012) Lianjun Zhang et al.   PLoS One

Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold

(2012) T. L. Stephen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thymic epithelial cells: working class heroes for T cell development and repertoire selection

(2012) Graham Anderson et al.   TRENDS IN IMMUNOLOGY

TNF receptor family signaling in the development and functions of medullary thymic epithelial cells

(2012) Taishin Akiyama et al.   Frontiers in Immunology

Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors

(2011) K. M. Heinonen et al.   BLOOD

NKAP is required for T cell maturation and acquisition of functional competency

(2011) Fan-Chi Hsu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress

(2011) Karan P. Sanghera et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

(2011) Kai Yang et al.   NATURE IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Regulatory T cell lineage commitment in the thymus

(2011) Ludger Klein et al.   SEMINARS IN IMMUNOLOGY

B7/CD28 in Central Tolerance: Costimulation Promotes Maturation of Regulatory T Cell Precursors and Prevents Their Clonal Deletion

(2011) Maria Hinterberger et al.   Frontiers in Immunology

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

(2010) S. Zhang et al.   BLOOD

Mammalian Target of Rapamycin Controls Dendritic Cell Development Downstream of Flt3 Ligand Signaling

(2010) Taheri Sathaliyawala et al.   IMMUNITY

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

Regulation of neural stem/progenitor cell maintenance by PI3K and mTOR

(2010) Atsushi Sato et al.   NEUROSCIENCE LETTERS

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

The Activation Threshold of CD4+ T Cells Is Defined by TCR/Peptide-MHC Class II Interactions in the Thymic Medulla

(2009) T. L. Stephen et al.   JOURNAL OF IMMUNOLOGY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology