Native and Bioengineered Exosomes for Ischemic Stroke Therapy

Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke

(2020) Han Young Kim et al.   BIOMATERIALS

Extracellular vesicles based electrochemical biosensors for detection of cancer cells: A review

(2020) Hui Xie et al.   CHINESE CHEMICAL LETTERS

Small Extracellular Microvesicles Mediated Pathological Communications between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanisms Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice

(2020) Lu Gan et al.   CIRCULATION

The specific ex vivo released cytokine profile is associated with ischemic stroke outcome and improves its prediction

(2020) Elzbieta Klimiec-Moskal et al.   Journal of Neuroinflammation

Inside(sight) of tiny communicator: exosome biogenesis, secretion, and uptake

(2020) Anshul S. Jadli et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MSCs-Derived Exosomes Attenuate Acute Brain Injury and Inhibit Microglial Inflammation by Reversing CysLT2R-ERK1/2 Mediated Microglia M1 Polarization

(2020) Yangmin Zhao et al.   NEUROCHEMICAL RESEARCH

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Systemic conditioned medium treatment from interleukin-1 primed mesenchymal stem cells promotes recovery after stroke

(2020) Catriona J. Cunningham et al.   Stem Cell Research & Therapy

Low dose of extracellular vesicles identified that promote recovery after ischemic stroke

(2020) Laura Otero-Ortega et al.   Stem Cell Research & Therapy

Exosomes derived from HeLa cells break down vascular integrity by triggering endoplasmic reticulum stress in endothelial cells

(2020) Yinuo Lin et al.   Journal of Extracellular Vesicles

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Development of a lateral flow aptamer assay strip for facile identification of theranostic exosomes isolated from human lung carcinoma cells

(2020) Qiang Yu et al.   ANALYTICAL BIOCHEMISTRY

Recent advances in single extracellular vesicle detection methods

(2020) Su Wang et al.   BIOSENSORS & BIOELECTRONICS

Extracellular Vesicle-Mediated Delivery of CircSCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models

(2020) Li Yang et al.   CIRCULATION

Exosome-mediated protection of auditory hair cells from ototoxic insults

(2020) Ulrich Müller   JOURNAL OF CLINICAL INVESTIGATION

Rabies virus glycoprotein-amplified hierarchical targeted hybrids capable of magneto-electric penetration delivery to orthotopic brain tumor

(2020) Yu-Lin Su et al.   JOURNAL OF CONTROLLED RELEASE

Early Single-Dose Exosome Treatment Improves Neurologic Outcomes in a 7-Day Swine Model of Traumatic Brain Injury and Hemorrhagic Shock

(2020) Aaron M. Williams et al.   Journal of Trauma and Acute Care Surgery

Transplantation of Human Mesenchymal Stem-Cell-Derived Exosomes Immobilized in an Adhesive Hydrogel for Effective Treatment of Spinal Cord Injury

(2020) Liming Li et al.   NANO LETTERS

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

(2020) Ricardo Cerqueira de Abreu et al.   Nature Reviews Cardiology

Trends in Stroke Incidence in High-Income Countries in the 21st Century

(2020) Linxin Li et al.   STROKE

Isolation and Characterization of Neural Progenitor Cells From Bone Marrow in Cell Replacement Therapy of Brain Injury

(2020) Wen-fang Bai et al.   Frontiers in Cellular Neuroscience

Exosomes Derived from Brain Metastatic Breast Cancer Cells Destroy the Blood-Brain Barrier by Carrying lncRNA GS1-600G8.5

(2020) Yunhe Lu et al.   Biomed Research International

Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis

(2020) Selma Maacha et al.   Stem Cells International

Differentiation of Human Mesenchymal Stem Cells from Wharton’s Jelly Towards Neural Stem Cells Using a Feasible and Repeatable Protocol

(2020) Ewa Kruminis-Kaszkiel et al.   Cells

Exosomes Derived from Human Neural Stem Cells Stimulated by Interferon Gamma Improve Therapeutic Ability in Ischemic Stroke Model

(2020) Guilong Zhang et al.   Journal of Advanced Research

An Analysis of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Preclinical Use

(2020) Alvin Tieu et al.   ACS Nano

Gene-modified exosomes protect the brain against prolonged deep hypothermic circulatory arrest

(2020) Jiang Shi et al.   ANNALS OF THORACIC SURGERY

Bioinspired exosome-like therapeutics and delivery nanoplatforms

(2020) Mei Lu et al.   BIOMATERIALS

State-of-the-art exosome loading and functionalization techniques for enhanced therapeutics: a review

(2020) Javier Donoso-Quezada et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Moderate exercise has beneficial effects on mouse ischemic stroke by enhancing the functions of circulating endothelial progenitor cell-derived exosomes

(2020) Jinju Wang et al.   EXPERIMENTAL NEUROLOGY

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

(2020) Joel W. Blanchard et al.   NATURE MEDICINE

Mesenchymal Stromal Cell–Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils

(2020) Chen Wang et al.   STROKE

Extracellular vesicle–encapsulated IL-10 as novel nanotherapeutics against ischemic AKI

(2020) Tao-Tao Tang et al.   Science Advances

Engineered Extracellular Vesicles/Exosomes as a New Tool against Neurodegenerative Diseases

(2020) Flavia Ferrantelli et al.   Pharmaceutics

Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair

(2020) Heather Branscome et al.   Frontiers in Cell and Developmental Biology

Mesenchymal stromal cell-derived extracellular vesicles modulate microglia/macrophage polarization and protect the brain against hypoxia-ischemic injury in neonatal mice by targeting delivery of miR-21a-5p

(2020) Danqing Xin et al.   Acta Biomaterialia

Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance

(2020) Shubham Salunkhe et al.   JOURNAL OF CONTROLLED RELEASE

Plasma-derived exosome-like vesicles are enriched in lyso-phospholipids and pass the blood-brain barrier

(2020) Martin Jakubec et al.   PLoS One

Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia

(2020) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases

(2020) Tahereh Gharbi et al.   Frontiers in Cell and Developmental Biology

Exosome engineering: Current progress in cargo loading and targeted delivery

(2020) Shengyang Fu et al.   NanoImpact

Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications

(2020) Xiaojuan Zhang et al.   DEVELOPMENTAL CELL

Efficient encapsulation of biocompatible nanoparticles in exosomes for cancer theranostics

(2020) Tanziela Tanziela et al.   Nano Today

IL-4-polarized BV2 microglia cells promote angiogenesis by secreting exosomes

(2019) Yan Tian et al.   Advances in Clinical and Experimental Medicine

Mesenchymal Stem Cell-Derived Extracellular Vesicle Therapy for Stroke: Challenges and Progress

(2019) Oh Young Bang et al.   Frontiers in Neurology

The emerging role of exosomes in mental disorders

(2019) Saumeh Saeedi et al.   Translational Psychiatry

Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice

(2019) Huixin Zhang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Microglia-Derived Microvesicles Affect Microglia Phenotype in Glioma

(2019) Alfonso Grimaldi et al.   Frontiers in Cellular Neuroscience

Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

(2019) Zheng Gang Zhang et al.   Nature Reviews Neurology

Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders

(2019) Nisim Perets et al.   NANO LETTERS

The role of exosomal noncoding RNAs in cancer

(2019) Yan Xie et al.   Molecular Cancer

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

(2019) Milad Riazifar et al.   ACS Nano

RAB27B‐activated secretion of stem‐like tumor exosomes delivers the biomarker microRNA‐146a‐5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer

(2019) Wei‐Chung Cheng et al.   INTERNATIONAL JOURNAL OF CANCER

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Mesenchymal derived exosomes enhance recovery of motor function in a monkey model of cortical injury

(2019) T.L. Moore et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood–brain barrier penetration

(2019) Mattaka Khongkow et al.   Scientific Reports

The biology of extracellular vesicles: The known unknowns

(2019) Leonid Margolis et al.   PLOS BIOLOGY

Therapeutic Potential of Neurotrophins for Repair After Brain Injury: A Helping Hand From Biomaterials

(2019) Josh Houlton et al.   Frontiers in Neuroscience

Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature

(2019) Kenneth W. Witwer et al.   Journal of Extracellular Vesicles

Extracellular Vesicles as Therapeutics for Brain Injury and Disease

(2019) Dinesh Upadhya et al.   CURRENT PHARMACEUTICAL DESIGN

Delivery of High Mobility Group Box-1 siRNA Using Brain-Targeting Exosomes for Ischemic Stroke Therapy

(2019) Minkyung Kim et al.   Journal of Biomedical Nanotechnology

Neuroinflammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles

(2019) Sylwia Dabrowska et al.   Journal of Neuroinflammation

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HucMSCs-Derived miR-206-Knockdown Exosomes Contribute to Neuroprotection in Subarachnoid Hemorrhage Induced Early Brain Injury by Targeting BDNF

(2019) Hao Zhao et al.   NEUROSCIENCE

Role of Exosomes in Central Nervous System Diseases

(2019) Wanying Liu et al.   Frontiers in Molecular Neuroscience

Extracellular vesicles from mesenchymal stem cells reduce microglial-mediated neuroinflammation after cortical injury in aged Rhesus monkeys

(2019) Veronica Go et al.   GeroScience

Neuroprotection by mesenchymal stem cell (MSC) administration is enhanced by local cooling infusion (LCI) in ischemia

(2019) Wenjing Wei et al.   BRAIN RESEARCH

Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain

(2019) Maheedhar Kodali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes

(2019) Gyeungyun Kim et al.   JOURNAL OF CONTROLLED RELEASE

Extracellular vesicles and their roles in stem cell biology

(2019) Yun H. Hur et al.   STEM CELLS

MicroRNA-126-3p/-5p Overexpression Attenuates Blood-Brain Barrier Disruption in a Mouse Model of Middle Cerebral Artery Occlusion

(2019) Jiaji Pan et al.   STROKE

Trends in mesenchymal stem cell clinical trials 2004‐2018: Is efficacy optimal in a narrow dose range?

(2019) Maciej Kabat et al.   Stem Cells Translational Medicine

Methotrexate-Loaded Extracellular Vesicles Functionalized with Therapeutic and Targeted Peptides for the Treatment of Glioblastoma Multiforme

(2018) Zhilan Ye et al.   ACS Applied Materials & Interfaces

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

(2018) Gang Jia et al.   BIOMATERIALS

Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis

(2018) Chaitra Venugopal et al.   CURRENT GENE THERAPY

Intravenous xenogeneic human cardiosphere-derived cell extracellular vesicles (exosomes) improves behavioral function in small-clot embolized rabbits

(2018) Paul A. Lapchak et al.   EXPERIMENTAL NEUROLOGY

The Immune System and Stroke: From Current Targets to Future Therapy

(2018) Kyle Malone et al.   IMMUNOLOGY AND CELL BIOLOGY

Multipotent mesenchymal stromal cell–derived exosomes improve functional recovery after experimental intracerebral hemorrhage in the rat

(2018) Yuxia Han et al.   JOURNAL OF NEUROSURGERY

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons

(2018) Amrita Datta Chaudhuri et al.   Cell Death & Disease

Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke

(2018) Fan Wang et al.   CELL TRANSPLANTATION

Exosome-like nanovectors for drug delivery in cancer

(2018) Noemi Arrighetti et al.   CURRENT MEDICINAL CHEMISTRY

Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease

(2018) Mengke Qu et al.   JOURNAL OF CONTROLLED RELEASE

Role of Exosomes as a Treatment and Potential Biomarker for Stroke

(2018) Laura Otero-Ortega et al.   Translational Stroke Research

Recent progress of drug nanoformulations targeting to brain

(2018) Abdur Rauf Khan et al.   JOURNAL OF CONTROLLED RELEASE

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Circulating Extracellular Vesicles in Human Disease

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Application of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Stroke: Biodistribution and MicroRNA Study

(2018) Gyeong Joon Moon et al.   Translational Stroke Research

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

(2017) David Rufino-Ramos et al.   JOURNAL OF CONTROLLED RELEASE

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury

(2017) Alok Kumar et al.   Journal of Neuroinflammation

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

(2017) Qianfa Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model

(2017) Robin L. Webb et al.   Translational Stroke Research

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Corrigendum to “Increasing Dose of Autologous Bone Marrow Mononuclear Cells Transplantation Is Related to Stroke Outcome: Results from a Pooled Analysis of Two Clinical Trials”

(2017) Francisco Moniche et al.   Stem Cells International

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes

(2016) Shu Wen Wen et al.   CANCER RESEARCH

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury

(2016) Anuradha Kalani et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery

(2016) Helena M. van Dongen et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons

(2016) Yi Zhang et al.   MOLECULAR NEUROBIOLOGY

Extracellular vesicles and viruses: Are they close relatives?

(2016) Esther Nolte-‘t Hoen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

Neuronal and Vascular Interactions

(2015) Benjamin J. Andreone et al.   Annual Review of Neuroscience

Stabilization of Exosome-targeting Peptides via Engineered Glycosylation

(2015) Michelle E. Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Surface Functionalization of Exosomes Using Click Chemistry

(2014) Tyson Smyth et al.   BIOCONJUGATE CHEMISTRY

Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

(2014) Liang Ma et al.   CELL RESEARCH

Serotonin stimulates secretion of exosomes from microglia cells

(2014) Konstantin Glebov et al.   GLIA

Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions

(2014) L. Vojtech et al.   NUCLEIC ACIDS RESEARCH

Exosomes/miRNAs as mediating cell-based therapy of stroke

(2014) Hongqi Xin et al.   Frontiers in Cellular Neuroscience

Extracellular vesicles: structure, function, and potential clinical uses in renal diseases

(2013) F.T. Borges et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression

(2013) Aldo M. Roccaro et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model

(2013) Suyan Bian et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

(2013) Hongqi Xin et al.   STEM CELLS

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

(2013) Marcel Grapp et al.   Nature Communications

HIV entry: a game of hide-and-fuse?

(2013) Gregory B Melikyan   Current Opinion in Virology

Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice

(2012) Hiroyuki Sakata et al.   BRAIN

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

SiRNA delivery with exosome nanoparticles

(2011) Jasper G van den Boorn et al.   NATURE BIOTECHNOLOGY

Novel CDNF/MANF family of neurotrophic factors

(2010) Päivi Lindholm et al.   Developmental Neurobiology

C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction

(2010) M. Guescini et al.   EXPERIMENTAL CELL RESEARCH

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway

(2008) N. Izquierdo-Useros et al.   BLOOD

Click Chemistry, A Powerful Tool for Pharmaceutical Sciences

(2008) Christopher D. Hein et al.   PHARMACEUTICAL RESEARCH