Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions

A comparison of methods to assess cell mechanical properties

(2018) Pei-Hsun Wu et al.   NATURE METHODS

The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion

(2018) Marco Padilla-Rodriguez et al.   Nature Communications

Distinct focal adhesion protein modules control different aspects of mechanotransduction

(2017) Ben Stutchbury et al.   JOURNAL OF CELL SCIENCE

Mechanoreciprocity in cell migration

(2017) Sjoerd van Helvert et al.   NATURE CELL BIOLOGY

Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

(2017) Dariusz Lachowski et al.   Scientific Reports

MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis

(2016) Madeleine J. Oudin et al.   MOLECULAR BIOLOGY OF THE CELL

The FAK–Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin

(2016) Vinay Swaminathan et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis

(2016) Shinuo Weng et al.   NATURE MATERIALS

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

(2016) M. J. Oudin et al.   Cancer Discovery

Correlating confocal microscopy and atomic force indentation reveals metastatic cancer cells stiffen during invasion into collagen I matrices

(2016) Jack R. Staunton et al.   Scientific Reports

Selectivity in subunit composition of Ena/VASP tetramers

(2015) D. N. Riquelme et al.   BIOSCIENCE REPORTS

Rac1-Dependent Phosphorylation and Focal Adhesion Recruitment of Myosin IIA Regulates Migration and Mechanosensing

(2015) Ana M. Pasapera et al.   CURRENT BIOLOGY

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area

(2014) Stephanie Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin II in mechanotransduction: master and commander of cell migration, morphogenesis, and cancer

(2013) Rocío Aguilar-Cuenca et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration

(2013) Thomas Iskratsch et al.   DEVELOPMENTAL CELL

Actin stress fibre subtypes in mesenchymal-migrating cells

(2013) T. Vallenius   Open Biology

Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion

(2012) Ghassan Mouneimne et al.   CANCER CELL

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Mena binds α5 integrin directly and modulates α5β1 function

(2012) Stephanie L. Gupton et al.   JOURNAL OF CELL BIOLOGY

Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility

(2012) Mei Rosa Ng et al.   JOURNAL OF CELL BIOLOGY

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

(2012) Patrick W. Oakes et al.   JOURNAL OF CELL BIOLOGY

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

(2012) Matthew Raab et al.   JOURNAL OF CELL BIOLOGY

A Zyxin-Mediated Mechanism for Actin Stress Fiber Maintenance and Repair

(2010) Mark A. Smith et al.   DEVELOPMENTAL CELL

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration

(2010) Daniel C. Worth et al.   JOURNAL OF CELL BIOLOGY

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Neurite growth in 3D collagen gels with gradients of mechanical properties

(2008) Harini G. Sundararaghavan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo

(2008) Sumanta Goswami et al.   CLINICAL & EXPERIMENTAL METASTASIS

Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner

(2008) H. Hirata et al.   JOURNAL OF CELL SCIENCE

Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

(2008) Colin K. Choi et al.   NATURE CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY