Impaired Mitochondrial Function in iPSC-Retinal Pigment Epithelium with the Complement Factor H Polymorphism for Age-Related Macular Degeneration

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

(2020) Kai Kaarniranta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Improving retinal mitochondrial function as a treatment for age-related macular degeneration

(2020) Mara C. Ebeling et al.   Redox Biology

Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells

(2020) Angela Armento et al.   Scientific Reports

Complement modulation reverses pathology in Y402H ‐retinal pigment epithelium cell model of age‐related macular degeneration by restoring lysosomal function

(2020) Edvinas Cerniauskas et al.   Stem Cells Translational Medicine

Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration

(2019) Chrishne Sivapathasuntharam et al.   Scientific Reports

Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice

(2019) Michael Landowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Acetyl-L-cysteine Protects Human Retinal Pigment Epithelial Cells from Oxidative Damage: Implications for Age-Related Macular Degeneration

(2019) Marcia R. Terluk et al.   Oxidative Medicine and Cellular Longevity

Membrane trafficking as an active regulator of constitutively secreted cytokines

(2019) Natalia H. Revelo et al.   JOURNAL OF CELL SCIENCE

CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex

(2019) Céline Borras et al.   Scientific Reports

Stem cell‐derived retinal pigment epithelium from patients with age‐related macular degeneration exhibit reduced metabolism and matrix interactions

(2019) Jie Gong et al.   Stem Cells Translational Medicine

Intracellular complement activation—An alarm raising mechanism?

(2018) M.P. Reichhardt et al.   SEMINARS IN IMMUNOLOGY

Interleukin-1 Beta—A Friend or Foe in Malignancies?

(2018) Rebekka Bent et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration

(2018) Gulpreet Kaur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment

(2017) Maartje J. Geerlings et al.   MOLECULAR IMMUNOLOGY

Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration

(2017) Zhouhui Geng et al.   PLoS One

The eye as a complement dysregulation hotspot

(2017) Simon J. Clark et al.   Seminars in Immunopathology

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure

(2017) Dean Hallam et al.   STEM CELLS

Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration

(2017) Nady Golestaneh et al.   Cell Death & Disease

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

(2017) Mark A Kanow et al.   eLife

Keeping It All Going—Complement Meets Metabolism

(2017) Martin Kolev et al.   Frontiers in Immunology

Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration

(2017) Deborah A. Ferrington et al.   Redox Biology

Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cells

(2017) Mark A. Fields et al.   PLoS One

CFH Y402H polymorphism and the complement activation product C5a: effects on NF-κB activation and inflammasome gene regulation

(2016) Sijia Cao et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes

(2016) M Martin et al.   CELL DEATH AND DIFFERENTIATION

A novel “complement-metabolism-inflammasome axis” as a key regulator of immune cell effector function

(2016) Giuseppina Arbore et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration

(2016) Deborah A. Ferrington et al.   EXPERIMENTAL EYE RESEARCH

Complement-Mediated Regulation of Metabolism and Basic Cellular Processes

(2016) Christoph Hess et al.   IMMUNITY

Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration

(2016) Nady Golestaneh et al.   Journal of Translational Medicine

In Pursuit of Authenticity: Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Clinical Applications

(2016) Kiyoharu J. Miyagishima et al.   Stem Cells Translational Medicine

Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms

(2016) Yang Luo et al.   Frontiers in Immunology

Investigating Mitochondria as a Target for Treating Age-Related Macular Degeneration

(2015) M. R. Terluk et al.   JOURNAL OF NEUROSCIENCE

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light

(2015) Karin C. Calaza et al.   NEUROBIOLOGY OF AGING

The Bioenergetic Health Index: a new concept in mitochondrial translational research

(2014) Balu K. Chacko et al.   CLINICAL SCIENCE

Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines

(2014) Jin Yang et al.   HUMAN MOLECULAR GENETICS

The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress

(2014) Yun-Ching Chang et al.   Frontiers in Aging Neuroscience

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

(2013) M. Kathryn Liszewski et al.   IMMUNITY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype

(2012) Reecha Sofat et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Impaired Binding of the Age-related Macular Degeneration-associated Complement Factor H 402H Allotype to Bruch's Membrane in Human Retina

(2010) Simon J. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement control protein factor H: The good, the bad, and the inadequate

(2010) Viviana P. Ferreira et al.   MOLECULAR IMMUNOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Annexin-II, DNA, and Histones Serve as Factor H Ligands on the Surface of Apoptotic Cells

(2009) Jonatan Leffler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

(2009) Don H. Anderson et al.   PROGRESS IN RETINAL AND EYE RESEARCH