Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells
Authors
Keywords
-
Journal
Scientific Reports
Volume 10, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-06-25
DOI
10.1038/s41598-020-67292-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration
- (2019) Chrishne Sivapathasuntharam et al. Scientific Reports
- Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice
- (2019) Michael Landowski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Oxidative Stress and Dysfunctional Intracellular Traffic Linked to an Unhealthy Diet Results in Impaired Cargo Transport in the Retinal Pigment Epithelium (RPE)
- (2019) Eloise Keeling et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors
- (2019) Emily E. Brown et al. Redox Biology
- Understanding membrane remodelling initiated by photosensitized lipid oxidation
- (2019) Tayana Mazin Tsubone et al. BIOPHYSICAL CHEMISTRY
- Extracellular matrix and oxidative stress regulate human retinal pigment epithelium growth
- (2019) Steven S. Eamegdool et al. FREE RADICAL BIOLOGY AND MEDICINE
- CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex
- (2019) Céline Borras et al. Scientific Reports
- Oxidative Stress Increases Endogenous Complement-Dependent Inflammatory and Angiogenic Responses in Retinal Pigment Epithelial Cells Independently of Exogenous Complement Sources
- (2019) Trakkides et al. Antioxidants
- Mitochondrial quality control in AMD: does mitophagy play a pivotal role?
- (2018) Juha M. T. Hyttinen et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A new perspective on lipid research in age-related macular degeneration
- (2018) Elisabeth M. van Leeuwen et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration
- (2018) Matthew Krilis et al. FREE RADICAL BIOLOGY AND MEDICINE
- PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD Pathogenesis
- (2018) Kai Kaarniranta et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells
- (2018) Aditi Swarup et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
- (2018) Szabolcs Felszeghy et al. Redox Biology
- Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration
- (2017) Nady Golestaneh et al. Cell Death & Disease
- Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye
- (2017) Mark A Kanow et al. eLife
- Bruch’s Membrane Compartmentalizes Complement Regulation in the Eye with Implications for Therapeutic Design in Age-Related Macular Degeneration
- (2017) Simon J. Clark et al. Frontiers in Immunology
- Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration
- (2017) Deborah A. Ferrington et al. Redox Biology
- Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes
- (2016) M Martin et al. CELL DEATH AND DIFFERENTIATION
- Increased retinal mtDNA damage in the CFH variant associated with age-related macular degeneration
- (2016) Deborah A. Ferrington et al. EXPERIMENTAL EYE RESEARCH
- Lysosomes: Regulators of autophagy in the retinal pigmented epithelium
- (2016) Debasish Sinha et al. EXPERIMENTAL EYE RESEARCH
- Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
- (2016) Mariela C. Marazita et al. Redox Biology
- Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants
- (2016) Blanca Molins et al. Scientific Reports
- The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor
- (2015) Cara J. Valvona et al. BRAIN PATHOLOGY
- Complement activation, regulation, and molecular basis for complement-related diseases
- (2015) G. Bajic et al. EMBO JOURNAL
- Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses
- (2015) Martin Kolev et al. IMMUNITY
- The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
- (2015) Alicia M. Pickrell et al. NEURON
- Complement System Part I – Molecular Mechanisms of Activation and Regulation
- (2015) Nicolas S. Merle et al. Frontiers in Immunology
- Age-Related Macular Degeneration: Genetics and Biology Coming Together
- (2014) Lars G. Fritsche et al. Annual Review of Genomics and Human Genetics
- A new pathway for mitochondrial quality control: mitochondrial-derived vesicles
- (2014) A. Sugiura et al. EMBO JOURNAL
- Transient Contraction of Mitochondria Induces Depolarization through the Inner Membrane Dynamin OPA1 Protein
- (2014) Hakjoo Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation
- (2013) M. Kathryn Liszewski et al. IMMUNITY
- Mitochondria and the Lectin Pathway of Complement
- (2013) Christel R. Brinkmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanisms of age-related macular degeneration and therapeutic opportunities
- (2013) Menno van Lookeren Campagne et al. JOURNAL OF PATHOLOGY
- Mitochondrial Dysfunction in Retinal Diseases
- (2012) Megha Barot et al. CURRENT EYE RESEARCH
- The retromer complex - endosomal protein recycling and beyond
- (2012) M. N. J. Seaman JOURNAL OF CELL SCIENCE
- Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids
- (2012) P. X. Shaw et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- VPS35 Mutations in Parkinson Disease
- (2011) Carles Vilariño-Güell et al. AMERICAN JOURNAL OF HUMAN GENETICS
- VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology
- (2011) Lei Wen et al. JOURNAL OF CELL BIOLOGY
- Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
- (2011) David Weismann et al. NATURE
- Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina
- (2011) Bhanu Dasari et al. BMC Ophthalmology
- Macromolecular diffusion characteristics of ageing human Bruch's membrane: Implications for age-related macular degeneration (AMD)
- (2010) A.A. Hussain et al. EXPERIMENTAL EYE RESEARCH
- Multiplex analysis of age-related protein and lipid modifications in human Bruch's membrane
- (2010) J. Renwick Beattie et al. FASEB JOURNAL
- Impaired Binding of the Age-related Macular Degeneration-associated Complement Factor H 402H Allotype to Bruch's Membrane in Human Retina
- (2010) Simon J. Clark et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulatory role of HIF-1α in the pathogenesis of age-related macular degeneration (AMD)
- (2009) Olli Arjamaa et al. AGEING RESEARCH REVIEWS
- Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration
- (2009) Kurt M. Bertram et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- ARPE-19 retinal pigment epitheliaL CELLS are highly resistant to oxidative stress and exercise strict control over their lysosomal redox-active iron
- (2009) Tino Kurz et al. Autophagy
- Loss of Drp1 function alters OPA1 processing and changes mitochondrial membrane organization
- (2009) Kristin Möpert et al. EXPERIMENTAL CELL RESEARCH
- Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins
- (2009) Christine A. Curcio et al. PROGRESS IN RETINAL AND EYE RESEARCH
- The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited
- (2009) Don H. Anderson et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Effects of particulates and lipids on the hydraulic conductivity of Matrigel
- (2008) William J. McCarty et al. JOURNAL OF APPLIED PHYSIOLOGY
- Tissue Inhibitor of Matrix Metalloproteinase-3 Levels in the Extracellular Matrix of Lung, Kidney, and Eye Increase With Age
- (2008) Anne M. Macgregor et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
- (2008) Y. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started