Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Methods for culturing retinal pigment epithelial cells: a review of current protocols and future recommendations

(2016) Aaron H Fronk et al.   Journal of Tissue Engineering

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

(2015) Ida Johansson et al.   Autophagy

Age-related macular degeneration: genome-wide association studies to translation

(2015) James R. M. Black et al.   GENETICS IN MEDICINE

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease

(2014) J. Duran et al.   HUMAN MOLECULAR GENETICS

Adenosine triphosphate-induced photoreceptor death and retinal remodeling in rats

(2014) Kirstan A. Vessey et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease

(2014) Taichiro Nishikawa et al.   JOURNAL OF HEPATOLOGY

The interplay between autophagy and mitochondrial dysfunction in oxidative stress-induced cardiac aging and pathology

(2014) Stephanie E. Wohlgemuth et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Studying Age-Related Macular Degeneration Using Animal Models

(2014) Erica L. Fletcher et al.   OPTOMETRY AND VISION SCIENCE

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

(2013) Kai Kaarniranta et al.   Autophagy

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Mitochondrial Dysfunction Indirectly Elevates ROS Production by the Endoplasmic Reticulum

(2013) Michael P. Murphy   Cell Metabolism

Klotho Regulates Retinal Pigment Epithelial Functions and Protects Against Oxidative Stress

(2013) M. Kokkinaki et al.   JOURNAL OF NEUROSCIENCE

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Dynamic Increase in Extracellular ATP Accelerates Photoreceptor Cell Apoptosis via Ligation of P2RX7 in Subretinal Hemorrhage

(2013) Shoji Notomi et al.   PLoS One

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

(2013) Johanna Viiri et al.   PLoS One

Elevated amyloid β production in senescent retinal pigment epithelium, a possible mechanism of subretinal deposition of amyloid β in age-related macular degeneration

(2012) Jiying Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single Nucleotide Polymorphism and Serum Levels of VEGFR2 are Associated With Age Related Macular Degeneration

(2012) Neel Kamal Sharma et al.   CURRENT NEUROVASCULAR RESEARCH

Age-related macular degeneration

(2012) Laurence S Lim et al.   LANCET

RPE cell senescence: A key contributor to age-related macular degeneration

(2012) Michael R. Kozlowski   MEDICAL HYPOTHESES

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Mechanisms of Age-Related Macular Degeneration

(2012) Jayakrishna Ambati et al.   NEURON

Noninvasive Imaging of Mitochondrial Dysfunction in Dry Age-Related Macular Degeneration

(2012) Matthew G. Field et al.   OPHTHALMIC SURGERY LASERS & IMAGING

Age-Related Changes in the Retinal Pigment Epithelium (RPE)

(2012) Xiaorong Gu et al.   PLoS One

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration

(2011) Kati Kinnunen et al.   ACTA OPHTHALMOLOGICA

Prevalence of Age-Related Macular Degeneration in the US Population

(2011) Ronald Klein   ARCHIVES OF OPHTHALMOLOGY

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Mitochondria and autophagy: Critical interplay between the two homeostats

(2011) Koji Okamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration

(2011) L. V. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy in health and disease. 5. Mitophagy as a way of life

(2010) Roberta A. Gottlieb et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress

(2010) Yongjun Wang et al.   HEPATOLOGY

Evidence for enhanced tissue factor expression in age-related macular degeneration

(2010) Youngeun Cho et al.   LABORATORY INVESTIGATION

Unknown

(2010) Antero Salminen et al.   MOLECULAR MEDICINE

Forecasting Age-Related Macular Degeneration Through the Year 2050

(2009) David B. Rein   ARCHIVES OF OPHTHALMOLOGY

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Mantle skewness and ridge segmentation

(2009) Satish C. Singh et al.   NATURE

Autophagy and Exosomes in the Aged Retinal Pigment Epithelium: Possible Relevance to Drusen Formation and Age-Related Macular Degeneration

(2009) Ai Ling Wang et al.   PLoS One

Direct control of mitochondrial function by mTOR

(2009) Arvind Ramanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fundus Autofluorescence and Progression of Age-related Macular Degeneration

(2009) Steffen Schmitz-Valckenberg et al.   SURVEY OF OPHTHALMOLOGY

Endoplasmic Reticulum Stress in Disease Pathogenesis

(2008) Jonathan H. Lin et al.   Annual Review of Pathology-Mechanisms of Disease

Use of p62/SQSTM1 antibodies for neuropathological diagnosis

(2007) E. Kuusisto et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY