Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration

Complement factor H in AMD: Bridging genetic associations and pathobiology

(2018) Christopher B. Toomey et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology

(2016) Jaimie Hoh Kam et al.   EXPERIMENTAL EYE RESEARCH

Selective accumulation of the complement membrane attack complex in aging choriocapillaris

(2016) Kathleen R. Chirco et al.   EXPERIMENTAL EYE RESEARCH

VEGF regulates local inhibitory complement proteins in the eye and kidney

(2016) Lindsay S. Keir et al.   JOURNAL OF CLINICAL INVESTIGATION

The metabolic regulation of aging

(2015) Toren Finkel   NATURE MEDICINE

Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light

(2015) Karin C. Calaza et al.   NEUROBIOLOGY OF AGING

Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue

(2014) JIAN-ZHENG ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular Degeneration

(2014) Simon Clark et al.   Journal of Clinical Medicine

Complement Component C3 Plays a Critical Role in Protecting the Aging Retina in a Murine Model of Age-Related Macular Degeneration

(2013) Jaimie Hoh Kam et al.   AMERICAN JOURNAL OF PATHOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Alterations of Choroidal Blood Flow Regulation in Young Healthy Subjects with Complement Factor H Polymorphism

(2013) Reinhard Told et al.   PLoS One

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Elevated membrane attack complex in human choroid with high risk complement factor H genotypes

(2011) Robert F. Mullins et al.   EXPERIMENTAL EYE RESEARCH

The retinal pigment epithelium of the eye regulates the development of scleral cartilage

(2010) H. Thompson et al.   DEVELOPMENTAL BIOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Complement Factor H Is Critical in the Maintenance of Retinal Perfusion

(2009) Peter Lundh von Leithner et al.   AMERICAN JOURNAL OF PATHOLOGY

Age-related increase in mitochondrial DNA damage and loss of DNA repair capacity in the neural retina

(2008) Ai Ling Wang et al.   NEUROBIOLOGY OF AGING

The locations of mitochondria in mammalian photoreceptors: Relation to retinal vasculature

(2007) Jonathan Stone et al.   BRAIN RESEARCH