Application of Animal Models in Cancer Research: Recent Progress and Future Prospects

Construction of 124I-trastuzumab for noninvasive PET imaging of HER2 expression: from patient-derived xenograft models to gastric cancer patients

(2020) Xiaoyi Guo et al.   Gastric Cancer

Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma

(2020) Jovana Petrović et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Tumour‐suppressive effect of oestrogen receptor β in colorectal cancer patients, colon cancer cells, and a zebrafish model

(2020) Geriolda Topi et al.   JOURNAL OF PATHOLOGY

The Core-Clock Gene NR1D1 Impacts Cell Motility In Vitro and Invasiveness in a Zebrafish Xenograft Colon Cancer Model

(2020) Alireza Basti et al.   Cancers

DFIQ, a Novel Quinoline Derivative, Shows Anticancer Potential by Inducing Apoptosis and Autophagy in NSCLC Cell and In Vivo Zebrafish Xenograft Models

(2020) Hurng-Wern Huang et al.   Cancers

Zebrafish xenograft model of human lung cancer for studying the function of LINC00152 in cell proliferation and invasion

(2020) Wenyi Shen et al.   Cancer Cell International

Anti-Cancer Activity of As4O6 and its Efficacy in a Series of Patient-Derived Xenografts for Human Cervical Cancer

(2020) Joseph J. Noh et al.   Pharmaceutics

Translating Human Cancer Sequences Into Personalized Porcine Cancer Models

(2019) Chunlong Xu et al.   Frontiers in Oncology

Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway

(2019) Xing Zhang et al.   Molecular Cancer

Rapid Analysis of Effects of Environmental Toxicants on Tumorigenesis and Inflammation Using a Transgenic Zebrafish Model for Liver Cancer

(2019) Qiqi Yang et al.   MARINE BIOTECHNOLOGY

A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal

(2019) Qiu Tu et al.   Disease Models & Mechanisms

Disruption of Endolysosomal RAB5/7 Efficiently Eliminates Colorectal Cancer Stem Cells

(2019) Mitsunobu Takeda et al.   CANCER RESEARCH

Efficacy of dendritic cell-based immunotherapy produced from cord blood in vitro and in a humanized NSG mouse cancer model

(2019) Gang Liu et al.   Immunotherapy

Orthotopic Patient-Derived Xenografts of Gastric Cancer to Decipher Drugs Effects on Cancer Stem Cells and Metastatic Dissemination

(2019) Julie Giraud et al.   Cancers

Trump administration halts fetal-tissue research by government scientists

(2019) Sara Reardon   NATURE

Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway

(2019) Tianhe Huang et al.   Oxidative Medicine and Cellular Longevity

An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses

(2019) Ismail M. Meraz et al.   Cancer Immunology Research

Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment

(2019) Elena Gómez-Abenza et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells

(2019) Olga Tanaskovic et al.   PLoS One

Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish

(2019) Colin D. Paul et al.   Cell Systems

Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis

(2019) Dongqin Yang et al.   EBioMedicine

Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts

(2019) Qing Li et al.   EBioMedicine

cGAMP inhibits tumor growth in colorectal cancer metastasis through the STING/STAT3 axis in a zebrafish xenograft model

(2019) Xiaofeng Jiang et al.   FISH & SHELLFISH IMMUNOLOGY

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis

(2019) Norihiro Yamaguchi et al.   eLife

Macrophages in Zebrafish Models of Liver Diseases

(2019) Arkadi Shwartz et al.   Frontiers in Immunology

Probiotic-Treated Super-Charged NK Cells Efficiently Clear Poorly Differentiated Pancreatic Tumors in Hu-BLT Mice

(2019) Kawaljit Kaur et al.   Cancers

Capecitabine Efficacy Is Correlated with TYMP and RB1 Expression in PDX Established from Triple-Negative Breast Cancers

(2018) Elisabetta Marangoni et al.   CLINICAL CANCER RESEARCH

Endoglin expression on cancer-associated fibroblasts regulates invasion and stimulates colorectal cancer metastasis

(2018) Madelon Paauwe et al.   CLINICAL CANCER RESEARCH

Talazoparib is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts

(2018) James H Laird et al.   CLINICAL CANCER RESEARCH

Activating transcription factor 4 modulates TGFβ-induced aggressiveness in triple negative breast cancer via SMAD2/3/4 and mTORC2 signaling

(2018) Adrián González-González et al.   CLINICAL CANCER RESEARCH

A novel immunodeficient rat model supports human lung cancer xenografts

(2018) Di He et al.   FASEB JOURNAL

microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-β2/TGF-βRIII signalings

(2018) Chi Fang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Gastrin inhibits gastric cancer progression through activating the ERK-P65-miR23a/27a/24 axis

(2018) Li-Dong Zu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Robustness and evolvability of heterogeneous cell populations

(2018) Andrei Kucharavy et al.   MOLECULAR BIOLOGY OF THE CELL

Cabozantinib exhibits potent antitumor activity in colorectal cancer patient-derived tumor xenograft models via autophagy and signaling mechanisms

(2018) Aaron J Scott et al.   MOLECULAR CANCER THERAPEUTICS

Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer

(2018) Amit Katz et al.   Oncotarget

Blocking CDK1/PDK1/β-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma

(2018) Chuan Xing Wu et al.   Theranostics

PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

(2018) Genevieve C Kendall et al.   eLife

Activation of Hepatic Stellate Cells During Liver Carcinogenesis Requires Fibrinogen/Integrin αvβ5 in Zebrafish

(2018) Chuan Yan et al.   NEOPLASIA

Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer

(2018) Shuai Li et al.   Redox Biology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Oncological and genetic factors impacting PDX model construction with NSG mice in pancreatic cancer

(2018) Shiwei Guo et al.   FASEB JOURNAL

Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model

(2018) Weijing Cai et al.   INVESTIGATIONAL NEW DRUGS

Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis

(2018) Chiara Borga et al.   LEUKEMIA

Adipose-derived stem cells enhance human breast cancer growth and cancer stem cell-like properties through adipsin

(2018) Hideaki Goto et al.   ONCOGENE

Angiotropism and extravascular migratory metastasis in cutaneous and uveal melanoma progression in a zebrafish model

(2018) Giulia Fornabaio et al.   Scientific Reports

Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches

(2018) Tiffany Leidy-Davis et al.   Scientific Reports

Comparison of efficacy and toxicity of bevacizumab, endostar and apatinib in transgenic and human lung cancer xenograftzebrafish model

(2018) Yinghua Jin et al.   Scientific Reports

Spatiotemporally Skewed Activation of Programmed Cell Death Receptor 1–Positive T Cells after Epstein-Barr Virus Infection and Tumor Development in Long-Term Fully Humanized Mice

(2018) Simon Danisch et al.   AMERICAN JOURNAL OF PATHOLOGY

Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma

(2018) S. Verykiou et al.   BRITISH JOURNAL OF DERMATOLOGY

Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis

(2018) Xing Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Chimeric Antigen Receptor–modified T Cells Repressed Solid Tumors and Their Relapse in an Established Patient-derived Colon Carcinoma Xenograft Model

(2018) Ruidi Teng et al.   JOURNAL OF IMMUNOTHERAPY

Promising preclinical platform for evaluation of immuno-oncology drugs using Hu-PBL-NSG lung cancer models

(2018) Kyoung Ho Pyo et al.   LUNG CANCER

Establishment of peripheral blood mononuclear cell-derived humanized lung cancer mouse models for studying efficacy of PD-L1/PD-1 targeted immunotherapy

(2018) Shouheng Lin et al.   mAbs

SMYD3 promotes the epithelial–mesenchymal transition in breast cancer

(2018) Claudio Fenizia et al.   NUCLEIC ACIDS RESEARCH

Triphala Suppresses Growth and Migration of Human Gastric Carcinoma Cells In Vitro and in a Zebrafish Xenograft Model

(2018) Jokyab Tsering et al.   Biomed Research International

Inducible Intestine-Specific Expression of kras Triggers Intestinal Tumorigenesis In Transgenic Zebrafish

(2018) Jeng-Wei Lu et al.   NEOPLASIA

Evaluation of reagents used to coat the hollow-fiber bioreactor membrane of the Quantum® Cell Expansion System for the culture of human mesenchymal stem cells

(2018) Nathan D. Frank et al.   Materials Science & Engineering C-Materials for Biological Applications

Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing

(2017) Kepin Wang et al.   GENOME RESEARCH

Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model

(2017) Chiara Gabellini et al.   INTERNATIONAL JOURNAL OF CANCER

Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer

(2017) Jia-Qi Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Recent Advances in Melanoma and Melanocyte Biology

(2017) Hensin Tsao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Combination of paclitaxel, bevacizumab and MEK162 in second line treatment in platinum-relapsing patient derived ovarian cancer xenografts

(2017) Francesca Ricci et al.   Molecular Cancer

Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma

(2017) Clare E. Weeden et al.   MOLECULAR CANCER THERAPEUTICS

Metformin Inhibits Cellular Proliferation and Bioenergetics in Colorectal Cancer Patient–Derived Xenografts

(2017) Nur-Afidah Mohamed Suhaimi et al.   MOLECULAR CANCER THERAPEUTICS

PRMT5 as a druggable target for glioblastoma therapy

(2017) Yeshavanth Kumar Banasavadi-Siddegowda et al.   NEURO-ONCOLOGY

EGFR gene status predicts response and survival benefit in a preclinical gastric cancer trial treating patient-derived xenografts with cetuximab

(2017) Xiaohong Wang et al.   ONCOLOGY REPORTS

Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts

(2017) Rita Fior et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish

(2017) J-W Lu et al.   Blood Cancer Journal

APIO-EE-9 is a novel Aurora A and B antagonist that suppresses esophageal cancer growth in a PDX mouse model

(2017) Guoguo Jin et al.   Oncotarget

A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug

(2017) Chen Chen et al.   Scientific Reports

Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression

(2017) Viviana Anelli et al.   eLife

Prevention of Human Lymphoproliferative Tumor Formation in Ovarian Cancer Patient-Derived Xenografts

(2017) Kristina A. Butler et al.   NEOPLASIA

The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform

(2017) Kyle M. Schachtschneider et al.   Frontiers in Oncology

Activation of liver stromal cells is associated with male-biased liver tumor initiation in xmrk and Myc transgenic zebrafish

(2017) Qiqi Yang et al.   Scientific Reports

Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer

(2016) Brittney S Harrington et al.   BRITISH JOURNAL OF CANCER

The anti-HER3 antibody in combination with trastuzumab exerts synergistic antitumor activity in HER2-positive gastric cancer

(2016) Qiwei Wang et al.   CANCER LETTERS

Patient-derived orthotopic xenograft (PDOX) mouse model of adult rhabdomyosarcoma invades and recurs after resection in contrast to the subcutaneous ectopic model

(2016) Kentaro Igarashi et al.   CELL CYCLE

Antitumor Effect of Programmed Death-1 (PD-1) Blockade in Humanized the NOG-MHC Double Knockout Mouse

(2016) Tadashi Ashizawa et al.   CLINICAL CANCER RESEARCH

Genetically engineered mouse models in oncology research and cancer medicine

(2016) Kelly Kersten et al.   EMBO Molecular Medicine

Vandetanib as a potential new treatment for estrogen receptor-negative breast cancers

(2016) Rana Hatem et al.   INTERNATIONAL JOURNAL OF CANCER

Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer

(2016) Taofeek K. Owonikoko et al.   Journal of Translational Medicine

Increased risk of melanoma in patients with chronic lymphocytic leukaemia

(2016) Catherine M. Olsen et al.   MELANOMA RESEARCH

Validation of a Preclinical Model of Diethylnitrosamine-Induced Hepatic Neoplasia in Yucatan Miniature Pigs

(2016) Jennifer Mitchell et al.   ONCOLOGY

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

(2016) Qin Tang et al.   Nature Communications

Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model

(2016) María Roel et al.   Oncotarget

Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy

(2016) Yukihiko Hiroshima et al.   Oncotarget

Dogs as a Model for Cancer

(2016) Heather L. Gardner et al.   Annual Review of Animal Biosciences

BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model

(2015) Chien-Chih Chiu et al.   BMC CANCER

Adult porcine genome-wide DNA methylation patterns support pigs as a biomedical model

(2015) Kyle M. Schachtschneider et al.   BMC GENOMICS

Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2R null Immunodeficient Mice

(2015) M. F. Sanmamed et al.   CANCER RESEARCH

Preclinical Efficacy of Ron Kinase Inhibitors Alone and in Combination with PI3K Inhibitors for Treatment of sfRon-Expressing Breast Cancer Patient-Derived Xenografts

(2015) M. Bieniasz et al.   CLINICAL CANCER RESEARCH

Integrating Murine and Clinical Trials with Cabozantinib to Understand Roles of MET and VEGFR2 as Targets for Growth Inhibition of Prostate Cancer

(2015) A. Varkaris et al.   CLINICAL CANCER RESEARCH

The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models

(2015) A. G. Schuller et al.   CLINICAL CANCER RESEARCH

Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas

(2015) H. Tsai et al.   CLINICAL CANCER RESEARCH

The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer

(2015) N. Antonio et al.   EMBO JOURNAL

Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China

(2015) Fang Ye et al.   FASEB JOURNAL

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

(2015) David S H Liu et al.   GUT

Induction of protective and therapeutic anti-cancer immunity by using bispecific anti-idiotype antibody G22-I50 for nasopharyngeal carcinoma

(2015) Jia-Jia Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution

(2015) Guang-Zhe Ge et al.   INTERNATIONAL JOURNAL OF CANCER

Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish

(2015) Chuan Yan et al.   JOURNAL OF HEPATOLOGY

XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer

(2015) J J Morton et al.   ONCOGENE

U0126 inhibits pancreatic cancer progression via the KRAS signaling pathway in a zebrafish xenotransplantation model

(2015) MENG GUO et al.   ONCOLOGY REPORTS

Establishment of a Patient-Derived Orthotopic Xenograft (PDOX) Model of HER-2-Positive Cervical Cancer Expressing the Clinical Metastatic Pattern

(2015) Yukihiko Hiroshima et al.   PLoS One

HER2 Activating Mutations Are Targets for Colorectal Cancer Treatment

(2015) S. M. Kavuri et al.   Cancer Discovery

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

(2015) Kimberley J. Evason et al.   PLoS Genetics

Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis

(2015) In Hye Jung et al.   NEOPLASIA

Human tumor infiltrating lymphocytes cooperatively regulate prostate tumor growth in a humanized mouse model

(2015) Michael D Roth et al.   Journal for ImmunoTherapy of Cancer

CXCR4 antibody treatment suppresses metastatic spread to the lung of intratibial human osteosarcoma xenografts in mice

(2014) Patrick Brennecke et al.   CLINICAL & EXPERIMENTAL METASTASIS

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

(2014) C. J. Veinotte et al.   Disease Models & Mechanisms

Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia

(2014) V. L. Bentley et al.   HAEMATOLOGICA

Transcriptomic analysis of a transgenic zebrafish hepatocellular carcinoma model reveals a prominent role of immune responses in tumour progression and regression

(2014) Zhen Li et al.   INTERNATIONAL JOURNAL OF CANCER

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor

(2014) Jason K Sicklick et al.   Journal of Translational Medicine

Mucosal melanoma

(2014) Alejandro A. Gru et al.   MELANOMA RESEARCH

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Quantitative Phenotyping-Based In Vivo Chemical Screening in a Zebrafish Model of Leukemia Stem Cell Xenotransplantation

(2014) Beibei Zhang et al.   PLoS One

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Assessment of Juvenile Pigs to Serve as Human Pediatric Surrogates for Preclinical Formulation Pharmacokinetic Testing

(2013) Wyatt J. Roth et al.   AAPS Journal

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

(2013) Anthony Rongvaux et al.   Annual Review of Immunology

Primary esophageal and gastro-esophageal junction cancer xenograft models: clinicopathological features and engraftment

(2013) Lorin Dodbiba et al.   LABORATORY INVESTIGATION

A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins

(2013) Stephen B. Keysar et al.   Molecular Oncology

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models

(2013) T W Chew et al.   ONCOGENE

Genome of the Chinese tree shrew

(2013) Yu Fan et al.   Nature Communications

Targeting BRAFV600E in an Inducible Murine Model of Melanoma

(2012) Anna I. Hooijkaas et al.   AMERICAN JOURNAL OF PATHOLOGY

Zebrafish xenografts as a tool for in vivo studies on human cancer

(2012) Martina Konantz et al.   Annals of the New York Academy of Sciences

Zebrafish screen identifies novel compound with selective toxicity against leukemia

(2012) S. Ridges et al.   BLOOD

Liver carcinogenesis: Rodent models of hepatocarcinoma and cholangiocarcinoma

(2012) Samuele De Minicis et al.   DIGESTIVE AND LIVER DISEASE

A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors

(2012) Z. Li et al.   Disease Models & Mechanisms

Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model

(2012) Shuning He et al.   JOURNAL OF PATHOLOGY

The zebrafish as a tool in leukemia research

(2012) Kaisa J. Teittinen et al.   LEUKEMIA RESEARCH

Analyses of pig genomes provide insight into porcine demography and evolution

(2012) Martien A. M. Groenen et al.   NATURE

Leukaemia xenotransplantation in zebrafish - chemotherapy response assay in vivo

(2011) Dale P. Corkery et al.   BRITISH JOURNAL OF HAEMATOLOGY

An inducible krasV12 transgenic zebrafish model for liver tumorigenesis and chemical drug screening

(2011) A. T. Nguyen et al.   Disease Models & Mechanisms

Zebrafish as a model for normal and malignant hematopoiesis

(2011) L. Jing et al.   Disease Models & Mechanisms

Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy

(2011) B. Pruvot et al.   HAEMATOLOGICA

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

(2011) Alejandro Gutierrez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inducible and repressable oncogene-addicted hepatocellular carcinoma in Tet-on xmrk transgenic zebrafish

(2011) Zhen Li et al.   JOURNAL OF HEPATOLOGY

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells

(2011) D. N. Vatakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal Anatomy and Histology of the Adult Zebrafish

(2011) Aswin L. Menke et al.   TOXICOLOGIC PATHOLOGY

Canine tumors: a spontaneous animal model of human carcinogenesis

(2011) Salomé S. Pinho et al.   Translational Research

Characterization of human B cells in umbilical cord blood-transplanted NOD/SCID mice

(2011) Xuefu Wang et al.   TRANSPLANT IMMUNOLOGY

Establishment and identification of a rabbit model of peritoneal carcinomatosis from gastric cancer

(2010) Lie-Jun Mei et al.   BMC CANCER

A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

(2009) S. Shimizu et al.   BLOOD

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

(2009) Ines J Marques et al.   BMC CANCER

Comparative expression pathway analysis of human and canine mammary tumors

(2009) Paolo Uva et al.   BMC GENOMICS

Immunotherapy for Human Renal Cell Carcinoma by Adoptive Transfer of Autologous Transforming Growth Factor  -Insensitive CD8+ T Cells

(2009) L. Wang et al.   CLINICAL CANCER RESEARCH

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation

(2009) Jing-Ruey J Yeh et al.   Nature Chemical Biology

Reduced PTEN Protein Expression and Its Prognostic Implications in Canine and Feline Mammary Tumors

(2009) L. Ressel et al.   VETERINARY PATHOLOGY

Oncogenic NRAS Cooperates with p53 Loss to Generate Melanoma in Zebrafish

(2009) Michael Dovey et al.   Zebrafish

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell