Development of apratoxin S10 (Apra S10) as an anti-pancreatic cancer agent and its preliminary evaluation in an orthotopic patient-derived xenograft (PDX) model

Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease

(2017) Kristina L. Go et al.   PANCREAS

Apratoxin S10, a Dual Inhibitor of Angiogenesis and Cancer Cell Growth To Treat Highly Vascularized Tumors

(2017) Weijing Cai et al.   ACS Medicinal Chemistry Letters

Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture

(2016) Kien Pham et al.   AMERICAN JOURNAL OF PATHOLOGY

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61

(2016) Kuan-Chun Huang et al.   MOLECULAR CANCER THERAPEUTICS

Patient-Derived Xenograft Models for Pancreatic Adenocarcinoma Demonstrate Retention of Tumor Morphology through Incorporation of Murine Stromal Elements

(2015) Daniel Delitto et al.   AMERICAN JOURNAL OF PATHOLOGY

Recent advances in pancreatic cancer: biology, treatment, and prevention

(2015) Divya Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Primary outgrowth cultures are a reliable source of human pancreatic stellate cells

(2015) Song Han et al.   LABORATORY INVESTIGATION

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity

(2014) Qi-Yin Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Apratoxin H and Apratoxin A Sulfoxide from the Red Sea Cyanobacterium Moorea producens

(2013) Christopher C. Thornburg et al.   JOURNAL OF NATURAL PRODUCTS

Targeting Tumor Architecture to Favor Drug Penetration: A New Weapon to Combat Chemoresistance in Pancreatic Cancer?

(2012) Man Yu et al.   CANCER CELL

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Regional Intra-Arterial vs. Systemic Chemotherapy for Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2012) Fenghua Liu et al.   PLoS One

nab -Paclitaxel Potentiates Gemcitabine Activity by Reducing Cytidine Deaminase Levels in a Mouse Model of Pancreatic Cancer

(2012) Kristopher K. Frese et al.   Cancer Discovery

Liposome based delivery systems in pancreatic cancer treatment: From bench to bedside

(2011) Feng Yang et al.   CANCER TREATMENT REVIEWS

Overcoming drug resistance in pancreatic cancer

(2011) Jiang Long et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Gemcitabine Plusnab-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial

(2011) Daniel D. Von Hoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Five Primary Human Pancreatic Adenocarcinoma Cell Lines Established by the Outgrowth Method

(2011) Felix Rückert et al.   JOURNAL OF SURGICAL RESEARCH

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity

(2011) Qi-Yin Chen et al.   ACS Medicinal Chemistry Letters

Evolved Diversification of a Modular Natural Product Pathway: Apratoxins F and G, Two Cytotoxic Cyclic Depsipeptides from a Palmyra Collection of Lyngbya bouillonii

(2010) Kevin Tidgewell et al.   CHEMBIOCHEM

Neural and hormonal regulation of pancreatic secretion

(2009) Rashmi Chandra et al.   CURRENT OPINION IN GASTROENTEROLOGY

Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation

(2009) Y. Liu et al.   MOLECULAR PHARMACOLOGY

Fluorocurcumins as Cyclooxygenase-2 Inhibitor: Molecular Docking, Pharmacokinetics and Tissue Distribution in Mice

(2009) Subhash Padhye et al.   PHARMACEUTICAL RESEARCH

Apratoxin E, a Cytotoxic Peptolide from a Guamanian Collection of the Marine CyanobacteriumLyngbya bouillonii

(2008) Susan Matthew et al.   JOURNAL OF NATURAL PRODUCTS

Apratoxin D, a Potent Cytotoxic Cyclodepsipeptide from Papua New Guinea Collections of the Marine CyanobacteriaLyngbya majusculaandLyngbya sordida

(2008) Marcelino Gutiérrez et al.   JOURNAL OF NATURAL PRODUCTS