Zebrafish screen identifies novel compound with selective toxicity against leukemia

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

(2011) Teresa Palomero et al.   CELL CYCLE

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

(2011) Alejandro Gutierrez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells

(2011) M Masiero et al.   LEUKEMIA

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

Fas Apoptosis Inhibitory Molecule Regulates T Cell Receptor-mediated Apoptosis of Thymocytes by Modulating Akt Activation and Nur77 Expression

(2010) Jianxin Huo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

(2010) Matthew R Janes et al.   NATURE MEDICINE

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

(2009) K. Cullion et al.   BLOOD

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss

(2009) H. Medyouf et al.   BLOOD

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

Dual Inhibition of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin as a New Therapeutic Option for T-Cell Acute Lymphoblastic Leukemia

(2009) F. Chiarini et al.   CANCER RESEARCH

Heritable T-cell malignancy models established in a zebrafish phenotypic screen

(2009) J K Frazer et al.   LEUKEMIA

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation

(2009) Jing-Ruey J Yeh et al.   Nature Chemical Biology

NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

(2008) V. Serra et al.   CANCER RESEARCH

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

(2008) Timothy A Yap et al.   CURRENT OPINION IN PHARMACOLOGY

Immunology and zebrafish: Spawning new models of human disease

(2008) Nathan D. Meeker et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Critical roles of the PI3K/Akt signaling pathway in T cell development

(2008) Marisa M. Juntilla et al.   IMMUNOLOGY LETTERS