Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

Chemical structure of phenothiazines and their biological activity

(2014) Agata Jaszczyszyn et al.   Pharmacological Reports

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

(2012) R. W. J. Groen et al.   BLOOD

Targeting Nonclassical Oncogenes for Therapy in T-ALL

(2012) Prem S. Subramaniam et al.   CANCER CELL

Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

(2012) Eleftherios Sachlos et al.   CELL

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response

(2012) Jaya Sangodkar et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency

(2012) J S Blackburn et al.   LEUKEMIA

Defined, serum-free conditions for in vitro culture of primary human T-ALL blasts

(2012) A J Yost et al.   LEUKEMIA

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma

(2011) R. Kridel et al.   BLOOD

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

(2011) Hind Medyouf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia

(2011) Alejandro Gutierrez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analysis of the chronic lymphocytic leukemia coding genome: role ofNOTCH1mutational activation

(2011) Giulia Fabbri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

(2011) Priscila P Zenatti et al.   NATURE GENETICS

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

(2011) Dan R Robinson et al.   NATURE MEDICINE

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

(2011) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch in T-ALL: new players in a complex disease

(2011) Ute Koch et al.   TRENDS IN IMMUNOLOGY

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1

(2010) T. D. Ashworth et al.   BLOOD

Identification of PP2A Complexes and Pathways Involved in Cell Transformation

(2010) A. A. Sablina et al.   CANCER RESEARCH

PP2A Regulatory Subunit PP2A-B′ Counteracts S6K Phosphorylation

(2010) Katrin Hahn et al.   Cell Metabolism

FTY720 Shows Promising In vitro and In vivo Preclinical Activity by Downmodulating Cyclin D1 and Phospho-Akt in Mantle Cell Lymphoma

(2010) Q. Liu et al.   CLINICAL CANCER RESEARCH

A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3′-kinase (PI3K)/AKT pathway in ovarian cancer cells

(2010) Seung Bae Rho et al.   GYNECOLOGIC ONCOLOGY

Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

(2010) Konstantinos J. Mavrakis et al.   NATURE CELL BIOLOGY

Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents

(2010) M. Dail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential Inhibition of PDK1/Akt Signaling by Phenothiazines Suppresses Cancer Cell Proliferation and Survival

(2009) Jang Hyun Choi et al.   Annals of the New York Academy of Sciences

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

(2009) K. Cullion et al.   BLOOD

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)

(2009) D. I. Marks et al.   BLOOD

A new genetic lesion in B-CLL: aNOTCH1PEST domain mutation

(2009) Mauro Di Ianni et al.   BRITISH JOURNAL OF HAEMATOLOGY

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels

(2009) John Koren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Outcome of Patients Treated for Relapsed or Refractory Acute Lymphoblastic Leukemia: A Therapeutic Advances in Childhood Leukemia Consortium Study

(2009) Richard H. Ko et al.   JOURNAL OF CLINICAL ONCOLOGY

CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia

(2009) Sara González-García et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of dopamine in the physiology of T-cells and dendritic cells

(2009) Rodrigo Pacheco et al.   JOURNAL OF NEUROIMMUNOLOGY

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

Identifying the proteins to which small-molecule probes and drugs bind in cells

(2009) S.-E. Ong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

(2008) F. Armstrong et al.   BLOOD

Oncogenic NOTCH1 Control of MYC and PI3K: Challenges and Opportunities for Anti-NOTCH1 Therapy in T-Cell Acute Lymphoblastic Leukemias and Lymphomas

(2008) T. Palomero et al.   CLINICAL CANCER RESEARCH

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

(2008) Mark Y. Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

(2008) Pedro J Real et al.   NATURE MEDICINE